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( Weiquan Shi ),( Tie Li ),( Zhifei Zhang ),( Bin Wang ) 한국액체미립화학회 2017 한국액체미립화학회 학술강연회 논문집 Vol.2017 No.-
In conventional LIF measurement with tracer added into fuels, selection of tracer is limited by its traceability including similar boiling point and diffusion coefficient etc. compared with targeted fuels, and pre-calibration between the LIF signals and the concentration must be done to obtain a quasi-quantitative information, limiting its application from wider fuel range. In this study, acetone is used as the tracer and it is introduced into the ambient gas. With accurate control of the mass fraction of acetone in the ambient gas, the on-site calibration between the LIF signals and acetone concentration can be implemented. Subsequently, when fuel is issued into the ambient, the quantitative fuel concentration can be obtained from the LIF signals of acetone, regardless of fuel properties. As a preliminary study, nitrogen as a representative of gas fuels is injected into the ambient of acetone and nitrogen by a high-pressure injector with a hole diameter of 0.2 mm. The fluorescence of the tracer is excited by the 266 nm light from the 4<sup>th</sup> harmonic of an Nd: YAG laser and recorded by an ICCD camera. The deduction of the fuel concentration from the tracer signals is described in details, the on-site calibration processes and uncertainties are also discussed. Finally, the mixture formation processes of the intermittent gas jets with different injection pressures are visualized and quantified.
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Weiguang Gu,Hua Zhang,Yiyu Lu,Minjing Li,Shuang Yang,Jianmiao Liang,Zhijian Ye,Zhihua Li,Minhong He,Xiaoliang Shi,Fei Wang,Dong You,Weiquan Gu,Weineng Feng 대한암학회 2023 Cancer Research and Treatment Vol.55 No.3
Purpose We aimed to evaluate whether the addition of pemetrexed is effective in improving progression-free survival (PFS) in epidermal growth factor receptor (EGFR)–mutated patients with or without concomitant alterations. Materials and Methods This multicenter clinical trial was conducted in China from June 15, 2018, to May 31, 2019. A total of 92 non–small cell lung cancer (NSCLC) patients harboring EGFR-sensitive mutations were included and divided into concomitant and non-concomitant groups. Patients in each group were randomly treated with EGFR–tyrosine kinase inhibitor (TKI) monotherapy or EGFR-TKI combined with pemetrexed in a ratio of 1:1. PFS was recorded as the primary endpoint. Results The overall median PFS of this cohort was 10.1 months. There were no significant differences in PFS between patients with and without concomitant and between patients received TKI monotherapy and TKI combined with pemetrexed (p=0.210 and p=0.085, respectively). Stratification analysis indicated that patients received TKI monotherapy had a significantly longer PFS in non-concomitant group than that in concomitant group (p=0.002). In concomitant group, patients received TKI combined with pemetrexed had a significantly longer PFS than patients received TKI monotherapy (p=0.013). Molecular dynamic analysis showed rapidly emerging EGFR T790M in patients received TKI monotherapy. EGFR mutation abundance decreased in patients received TKI combined chemotherapy, which supports better efficacy for a TKI combined chemotherapy as compared to TKI monotherapy. A good correlation between therapeutic efficacy and a change in circulating tumor DNA (ctDNA) status was found in 66% of patients, supporting the guiding role of ctDNA minimal residual disease (MRD) in NSCLC treatment. Conclusion EGFR-TKI monotherapy is applicable to EGFR-sensitive patients without concomitant alterations, while a TKI combined chemotherapy is applicable to EGFR-sensitive patients with concomitant alterations. CtDNA MRD may be a potential biomarker for predicting therapeutic efficacy.
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