치매 치료에 대한 한의학적 접근 방법

황의완 경희대학교 1997 慶熙醫學 Vol.13 No.1

기능성 위장관장애 환자의 자율신경계기능과 음-양(陰陽)체질 특성에 관한 연구

이정호,송지영,황의완,정두훈,김영미 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.4

연구목적 : 기질적 원인이 없이 장기간 소화장애 및 복통이 지속되는 기능성 위장관 장애 환자를 대상으로 하여, 음양체질의 특성이 위장관을 조절하는 자율신경계 기능 이상과 관련되는지를 알아보기 위하여, 사상체질 특성에 따른 자율신경계 기능의 차이유무를 측정해 보고자 하였다. 이로써 이들 환자에서 보이는 자율신경계 기능의 불균형 상태가 한의학에서 말하는 음양(陰陽)이론으로 설명할 수 있을지 알아 보고자 하였다. 그리고 만일 이러한 설명이 가능하게 되면 향후 기능성 위장관 장애 환자에 대한 음양이론에 입각한 치료의 이론적 배경이 될 것으로 기대하였다. 방 법 : 기능성 위장관 장애 환자 27명과 대조군으로서 위장관 증상 이외의 증상을 가진 신체형 장애 환자(이하 기타 신체형 장애) 28명과 건강 대조군 26명을 조사 대상으로 하였다. 이들에게 사상체질(四象體質)분류검사를 이용하여 소음 체질과 기타 체질군으로 나누고, 자율신경 기능검사를 실시하여 체질에 따른 자율신경계 기능을 비교해 보았다. 결 과 : 기능성 위장관 환자군에서 소음체질이 의미있게 많은 빈도를 차지하지는 않았으며, 기능성 위장관 장애군과 기타 신체형 장애군과의 비교에서 자율신경 기능의 차이는 없었다. 이로서 비기질성 기능 장애의 하나인 기능성 위장 장애에서 체질 특성과 부교감신경계 기능 저하와는 관련성은 거의 없다고 추정된다. 단지 기능성 위장 장애군과 기타 신체형 장애군을 합한 신체형 장애 환자군에서는 건강 대조군에 비하여 소음체질의 빈도가 높았으며 부교감신경 기능이 의미있게 낮은 소견을 보였다. 결 론 : 비기질성 기능 장애인 기능성 위장관 장애에서는 한의학에서의 음양가설이라는 일원론에 입각한 이분법적인 개념이 자율신경계의 교감, 부교감 신경계 기능과 일치하는 부분은 적은 것으로 추정된다. 기능성 위장관 장애를 대상으로 해서 앞으로는 음양의 체질이라는 포괄적인 개념보다는 확실한 증상 몇 개 중심으로 하는 좀 더 세분화된 부분으로부터 접근해 볼 필요가 있으리라 사료된다. Objectives : It was revealed that autonomic dysfunction especially decreased parasympathetic functions, seems to be one of the major etiological factors in functional gastrointestinal disorders(FGID). The physiological characteristics of sympathetic and parasympathetic functions are externally similar to the features of Yin and Yang based on oriental medicine theory. And it was also revealed that gastrointestinal symptoms are prevalent in Lesser Yin con-stitutional type(少陰) originated from four types of constitution shown in Sasang constitutional theory(四象醫學). If we obtain the findings on the similarities or compatibilities between autonomic nervous functions and physical constitutional features in functional gastrointestinal disorders, we could apply various oriental treatment modalities to the patients with functional disorders, especially according to Yin-Yang constitutional concept. Methods : We investigated the correlations between characteristics of physical constitution (Yin and Yang) and imbalance of the autonomic functions in patients with FGID. Subjects consisted with three groups : 27 patients with FGID (including irritable bowel syndrome, functional dyspepsia, functional abdominal pain syndrome according to the Rome criteria), 28 patients with somatoform disorders who had symptoms other than abdominal symptoms(other somatoform disorders), and 26 normal healthy controls. Characteristics of constitutions were evaluated and divided into two major groups, i.e., Lesser Yin constitution and other constitutions(Greater Yin & Yang and Lesser Yang included) according to the Je-Ma Lee's Classification Questionnaire for Four Constitutional Types(Song et al. 1993). For evaluating the autonomic functions, three parasympathetic functions and two sympathetic functions were measured. Levels of anxiety and depression were also evaluated to be used as a covariant controlling the autonomic functions. Results : 1) FGID group showed significantly lower parasympathetic functions compared to healthy controls, however, there was no differences between FGID and other somatoform disorder groups. 2) Lesser Yin constitutional type was not so prevalent in FGID group. 3) When FGID and other somatoform disorder groups were combined and compared with normal healthy controls, the former group showed significantly lower parasympathetic functions than the latter group. Conclusions : According to these results, Lesser Yin constitutional type do not seem to be closely related with FGID. However, it was suggested that decreased parasympathetic functions were partly associated with this group. We could not find any correlations or compatibilities between two constitutional characteristics and autonomic dysfunction in FGID. This means that functional symptoms of FGID when those were deducted as Yin and Yang characteristics based on oriental medicine could not be understood as two oppositional and co-operative functions such as autonomic functions. Further research with more restricted symptoms selected in the functional disorders and with other physiological cues applied would be needed.

원저 : 치매에 관한 한의학적 임상연구 ( Original Article : Clinical Study on Dementia with Oriental Medicine )

황의완(Wei Wan Whang),김종우(Jong Woo Kim),이조희(Jo Hee Lee),엄효진(Hyo Jin Eom),이승기(Seung Gi Lee) 경희대학교 경희의료원 1996 慶熙醫學 Vol.12 No.2

치매에 대한 한의학적 임상연구

황의완(Wei Wan Whang),김종우(Jong Woo Kim),이조희(Jo Hee Lee),엄효진(Hyo Jin Eom),이승기(Seung Gi Lee) 대한한방신경정신과학회 1996 동의신경정신과학회지 Vol.7 No.1

N/A 1. Out of 21 examples on a clinical base Alzheimer type dementia were 8 examples(38%), 11 vascular types(52%), 1 Alzheimer and vascular mixed type and rest 1 was secondary dementia type(NPH). 2. Between the gendes, there were 5 males and 3 females for Alzheimer types, 6 males and 5 females for the vascular types, 1 male for Alzhrimer and vascular mixed type, and 1 frmale for secondary dementia type(NPH). 3. For the degrees of Alzheimer type dementia there were 2 mild dementia, 4 moderate dementia, and 2 severe dementia. 4. Among the Alzheimer types 2 mild dementia were almost recovered back to normal in approximately 2 months, 2of 4 moderate dementia became significantly better in approximately 2 months and recovered to almost normal state in 3 to 5 months. The rest 2 have been under treatment for 3 months, but showed a little improvement. Out of 2 severe dementia examples, one showed a little improvement even if it has been under treatment over 2 years. The other exampe did not show any improvement, but dementia did not proceed any more. 5. Among the 11 vascular examples, 7 recovered in 2 to 3 months, 1 in 5 months, 2 recovered in a year, and the treatment was stopped arbitrary for the last one. 6 In the case of Alzheimer and vascular mixed type dementia, even the moderate dementia did not show any apparent result in 6 months. 7. For NPHI (Normal Pressure Hydrocephalus), there was an improvement on dementia in 2 months after the treatment, but gait disturbance and urinary incontinence did not show any noticeable difference. As a conclusion, almost all the Alzheimer and vascular type patients recovered, but the treatment periods varied depending on the types of the dementia and the degree of seriousness, especially in the case of the severe Alzheimer patients, the treatment oniy suppression the progression of the dementia. The most important aspect from clinical point of view was even if almost all the patients were almost completely cired, they need to keep being cured for a long period of time. The methol with respect to Four Constitutions is thought of the most desirable.

調胃升淸탕이 Alzheimer's disease 모델 白鼠의 학습과 기억에 미치는 影響

黃義完,박순권,李雄錫,김현택 慶熙大學校韓醫科大學韓醫學硏究所 1998 慶熙韓醫大論文集 Vol.21 No.1

The effects of Jowiseungchungtang on the enhancement of learning and memory of AD model rats were studied with Morris water maze and radial arm maze. Sample group was electrolytically lesioned on nbM, and then daily treated with the medicine for two months. Control group with nbM lesion, and sham group with the sham operation were treated the vehicle for same duration. The following results were observed. 1. As the learning trials of Morris water maze processed repeatedly, sham group achieved 200.21±35.28 seconds in 1st trial, 153.14±62.66 seconds in 2nd, 109.93±42.57 seconds in 3rd, 79.29±50.07 seconds in 4th, and 48.07±29.39 seconds in 5th. The control group achieved 224.85±26.94 in 1st trial, 191.77±67.97 seconds in 2nd, 178.46±65.06 seconds in 3rd, 137.46±76.32 seconds in 4th, and 108.92±90.12 seconds in 5th. The sample group achieved 202.00±33.53 seconds in 1st trial, 196.17±40.65 seconds in 2nd, 172.50±56.30 seconds in 3rd, 88.75±47.70 seconds in 4th, and 84.17±59.73 seconds in 5th. Therefore, these data shows that all three groups were improved in learning capacity as trials were repeated, but the sample group showed more prominent improvement in learning compared with the control group(p<0.05). 2. In memory retention test of Morris water maze that counts the staying time in the target area, sham group stayed for 15.36±5.39 seconds, the control group stayed for 5.54±5.64 seconds, and the sample group stayed for 10.08±5.45 seconds. The analysis of the memory retention data shows that the sample group marked more significant improvement statistically in memory retention compared with the control group(p<0.05). 3. In the learning of radial arm maze, the number and rate of animals that arrive the learning criteria amounted 9 out of 14, 64.29% in sham group, none out of 13.0% in the control group, and 3 out of 12, 25.00% in the sample group. So, the sample group shows better learning capacity significantly compared with the control group(p<0.05). With the experimental results above, Jowiseungchungtang can be supposed to have the improving effects on the learning and memory of AD rats induced by eletronical injury of nbM.

麝香蘇合元이 Alzheimer's disease 모델 백서의 학습과 기억에 미치는 영향

황의완 대한한방신경정신과학회 1999 동의신경정신과학회지 Vol.10 No.1

The effects of Sahyangsohapwon on the enhancement of learning and memory of AD model rats were studied with Morris water maze and radial arm maze. Sample group was electrolytically lesioned on nbM, and then daily treated with the medicine for two months. Control group with nbM lesion, and sham group with the sham operation were treated the vehicle for same duration. The following results were observed. 1. In the learning trials of Morris water maze, all three groups were improved in learning capacity as trials were repeated, but the sham group showed more prominent improvement in learning compared with the control group(p〈0.01). 2. In memory retention test of Morris water maze, the sham group marked more significant improvement statistically in memory retention compared with the control group(p〈0.05). 3. In the learning of radial arm maze, the sham group shows better learning capacity significantly compared with the control group(p〈0.05). With the experimental results above, Sahyangsohapwon can be supposed to have the improving effects on the learning and memory of AD rats induced by electronical injury of nbM.

香附子八物湯이 Alzheimer's disease 모델 白鼠의 학습과 기억에 미치는 影響

강현근,김종우,황의완,김현택,이홍재 대한한방신경정신과학회 1999 동의신경정신과학회지 Vol.10 No.1

The effects of Hyangbujapalmutang on the enhancement of learning and memory of AD model rats were studied with Morris water maze. Sample group was electrolytically lesioned on nucleus basalis of Meynert(nbM), and then daily treated with the medicine for two months. Control group with nbM lesion, and sham group with the sham operation were treated the vehicle for the same duration. The following results were observed. 1. As the learning trials of Morris water maze were proceeded, sham group showed the escape latency from 54.7±2.28 seconds in 1st trial to 13.3±3.27 seconds in 7th. The control group showed the escape latency from 58.0±1.78 seconds in 1st trial to 51.3±3.52 seconds in 7th. The sample group showed the escape latency from 57.0±2.21 seconds in 1st trial to 28.4±4.82 seconds in 7th. Therefore, these data shows that all three groups were improved in learning capacity as trials were proceeded, but the sample group showed more prominent improvement in learning compared with the control group(p〈0.05). 2. In memory retention test of Morris water maze that counts the staying time in the target area during 30 seconds of freely swimming period, sham group stayed for 4.81±1.15 seconds, the control group stayed for 1.27±0.78 seconds, and the sample group stayed for 4.17±1.47 seconds. The analysis of the memory retention data shows that the sample group marked more improvement in memory retention compared with the control group, but could not obtained statistically significant result(p〈0.05). With the experimental results above, Hyangbujapalmultang can be supposed to have the improving effects on the learning of AD model rats induced by electrolytic lesion of nbM.

調胃升淸湯加鹿茸이 拘束스트레스 흰쥐의 抗스트레스와 免疫反應에 미치는 影響

황의완,김종우,엄효진 慶熙大學校韓醫科大學韓醫學硏究所 1997 慶熙韓醫大論文集 Vol.20 No.2

In order to investigate the anti-stress effect of Jowiseunchungtang plus Nokyong in immobilization stressed rats, the change of body weight and the plaque formation, the hemagglutination titer, the footpad swelling reaction, as the humoral and cellular immune response were measured. The following results were obtained. 1. The decrease of the body weight was significantly inhibited in test group, comparing with the control group. 2. In the plaque formation test, the number of the plaque in the control group was decreased, but, the decrease in test group was significantly inhibited, comparing with the control group. 3. In the hemagglutination titer, the control group was decreased on the serum antibody titer. but, the decrease in test group was significantly inhibited, comparing with the control group. 4. In the footpad swelling response, the differences between the control and test group were not shown.

四物安神湯의 效能에 關한 實驗的 硏究

黃義完 慶熙大學校韓醫科大學韓醫學硏究所 1984 慶熙韓醫大論文集 Vol.7 No.-

四物安神湯의 效能에 關한 實驗的 硏究

黃義完,李京燮 慶熙大學校韓醫科大學韓醫學硏究所 1983 慶熙韓醫大論文集 Vol.6 No.-