Associations of serotonergic genes with poststroke emotional incontinence

Kim, Jae‐,Min,Stewart, Robert,Kang, Hee‐,Ju,Bae, Kyung‐,Yeol,Kim, Sung‐,Wan,Shin, Il‐,Seon,Kim, Joon‐,Tae,Park, Man‐,Seok,Cho, Ki‐,Hyun,Yoon, Jin‐ John Wiley Sons, Ltd 2012 INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY Vol.27 No.8

<P><B>Objectives</B></P><P>Poststroke emotional incontinence (PSEI) has been associated with serotonergic dysfunction. Polymorphisms of serotonin transporter (5‐HTT) and serotonin 2a receptor (5‐HTR2a) genes may regulate serotonergic signaling at brain synapses, and this study was to investigate associations with PSEI in an East Asian population.</P><P><B>Methods</B></P><P>In 276 stroke cases, PSEI was diagnosed by Kim's criteria. Covariates included age, gender, education, history of depression or stroke, current depression, and stroke severity and location. Genotypes were ascertained for 5‐HTT gene‐linked promoter region (5‐HTTLPR), serotonin transporter intron 2 variable number tandem repeat, 5‐HTR2a 1438A/G, and 5‐HTR2a 102 T/C. Associations with PSEI were estimated by using logistic regression models, and gene–gene interactions were investigated by using the generalized multifactor dimensionality reduction method.</P><P><B>Results</B></P><P>PSEI was present in 37 (13.4%) patients. The 5‐HTT gene‐linked promoter region <I>s</I>/<I>s</I> genotype was independently associated with PSEI. No associations with STin2 VNTR and 5‐HTR2a genes were found, and no significant gene–gene interactions were identified.</P><P><B>Conclusions</B></P><P>Stroke patients with 5‐HTTLPR <I>s</I> allele had higher susceptibility to PSEI, which underlines the potential role of serotonergic pathways in its etiology. Copyright © 2011 John Wiley & Sons, Ltd.</P>

Effect of Developmental Lead Exposure on the Expression of Hippocampal NMDA Receptor Subunit mRNA

Kim, Tae-Wan,Chung, In-Sung,Bae, Jae-Hoon,Shin, Dong-Hoon,Lee, Mi-Young,Kim, Joon-Sik 大韓産業醫學會 2005 대한직업환경의학회지 Vol.17 No.4

목적: in vivo 및 vitro에서 해마 신경세포의 발생단계별 NMDA 수용체 아단위 mRNA 발현에 대한 연 폭로 영향을 알아보고자 하였다. 방법: 흰쥐 해마 신경세포의 발생단계별 NMDA 수용체 NR2A, NR2B 아단위 mRNA 발현에 대한 연의 영향은 정상군과 연 폭로군의 출생 후 7일, 14일, 22일 흰쥐의 해마에서 in situ hybridization으로 mRNA 발현 정도를 densitometer로 측정하여 비교하였고, 연과 NMDA 의 세포독성은 해마 신경세포 일차배양 후 도립현미경을 이용한 형태학적인 관찰과 LDH 활성도를 이용하여 측정하였다. 결과: 연 과 NMDA 에 의한 세포독성에 대한 in vitro 실험에서 형태학적 소견과 LDH 활성도에서 해마 미성숙 신경세포와 성숙 신경세포사이의 차이가 있었으므로, 연과 NMDA 독성효과는 해마 신경세포의 발달 단계에 따라 차이가 있다. 정상군의 해마에서의 NR2A mRNA 발현은 출생 후 연령이 증가함에 따라 점진적으로 증가하였으나, NR2B mRNA 발현은 출생 후 연령이 증가함에 따라 점진적으로 증가하였으나 NR2B mRNA 발현은 연령의 증가에 따른 변화가 없었다. 연 폭로에 희한 NR2A mRNA 발현은 유의하게 감소하였으나(p<0.05), NR2B mRNA 발현은 변화가 나타나지 않았다. 만성적 연 폭로는 NR2A를 포함하는 NMDA 수용체를 감소시킬 수 있음을 알 수 있다. 결론: 연은 해마신경세포의 발생단계에서 NMDA 수용체 아단위 특히 NR2A mRNA 발현의 변화를 야기하여 시냅스 신호 전달에 영향을 나타냄을 알 수 있었다. Hippocampus

선택분쇄 및 공기분급에 의한 일라이트의 정제기술 연구

김상배,조성백,김완태,윤성대 한국광물학회 2005 광물과 암석 (J.Miner.Soc.Korea) Vol.18 No.1

선택분쇄 및 분급 기술에 의한 영동지역에 산출하는 일라이트에 대한 정제연구를 수행하였다. 원광의 주 구성광물은 석영과 일라이트이며, 황철석과 섬아연석, 황동석 등과 같은 황화광물들 이 소량 수반된다. 습식 해쇄 후 체가름 결과, 미립자로 갈수록 Al₂O₃, K₂O 함량 및 강열감량은 높아지며, SiO₂함량은 낮아졌으며, Fe₂O₃의 함량은 굵은 입자가 다소 낮았으나 입도에 관계없이 비교적 균일하게 나타났다. 단체분리를 위한 충격식 분쇄기의 분쇄매체의 선속도가 증가함에 따라 미립자 생성율은 증가되었으며, 분급과정에서의 미립자 회수율 역시 증가되었다. 분쇄매체의 선속도를 57.6 m/sec로 조절하여 선택분쇄 후 최적의 조건으로 분급하면 정제산물을 76.16 wt% 정도 생산할 수 있었다. 정제산물의 화학조성은 SiO₂70.13%, Al₂O₃19.40%, Fe₂O₃ 1.62%, K₂O 5.20%, 1g.loss 2.77%이었다. 본 연구에서 사용한 정제공정은 비금속 광물의 정제와 입도조절 공정을 동시에 행할 수 있는 유용한 기술임을 알 수 있었다. A study on the beneficiation of illite occurring in Youngdong province is performed with applying selective grinding and air classification techniques. Quartz and illite are occurred as major components, and sulfide minerals such as pyrite, chalcopyrite are associated as minor components. The result of sieving test shows that contents of Al₂O₃, K₂O and ignition loss are increased, whereas SiO₂is decreased with particle size decrease. Fe₂O₃content is almost same in all the particle size range but slightly lower at coarse particles. The yield of fine particles is increased with increasing rotor speed in both grinding stage and air classification stage. When the selective grinding and air classification are carried out at optimal condition, yield of the concentrate is 76.16 wt.%. The chemical compositions of the concentrate are SiO₂70.13%, Al₂O₃19.40%, Fe₂O₃ 1.62%, K₂O 5.20% and ignition loss 2.77%. The beneficiation process developed in the current study is very effective method which purification and particle size control can be achieved simultaneously.

금형스프링을 이용한 송배전용 연결구조체의 내력실험

김호수,정희범,김진완,이배연,오병훈 청주대학교 산업과학연구소 2016 産業科學硏究 Vol.34 No.1

This study presents an experimental process to secure the capacity of mold spring connection structure for electric distribution cable. To this end, this study evaluates the capacity and safety of connection structure through the capacity experiment according to the various design variables

키틴질의 화학적 변환과 응용에 관한 고찰

金完永,金鍾培 全北大學校 1991 論文集 Vol.33 No.-

Chitin is a Polysaccharide constituted of β-(1→4)2-acetamido-2-deoxy-D-glucose units. This natural polymer can be formally considered a derivative of cellulose where the C-2 hydroxyl groups have been completely replaced by acetamide groups, and chitosan is its N-deacetylated products. Chitin is a main component of crab and shrimp shells, which are abandoned from their food processing, and is the second most plentiful natural polymer. The chemical modifications and applications of chitin and chitosan have been studied for several years in many different parts. In this study, the present situation and future prospect on the application of chitin and chitosan were discussed from a view point of the molecular design by chemical modifications.

중증 세균 감염 및 내성균에 대한 Fosfomycin의 치료효과

김찬기,노승무,윤완희,장일성,배진선,손기섭 충남대학교 의과대학 지역사회의학연구소 1991 충남의대잡지 Vol.18 No.1

A Clinical study for the therapeutic effect of Fosfomycin was made in 20 cases with the severe infection and the resistent organisms against the other antibiotics. Fosfomycin was administered intravenously 2-4 gm daily in two divided for an average of 13.1 days. The overall effectiveness was 90% without any significant side effect and the effectiveness for the resistant organisms(13 cases) against the other antibiotics was 84.6%. These results demonstrated that Fosfomycin can be used effectively in the treatment of the severe infection and the resistant organisms against the other antibiotics.

항암화학요법 치료시 환자에서 발생하는 오심 및 구토에서의 정맥주사용 및 경구용 Tropisetron의 제 4상 연구

배진선,김장용,장일성,윤완희,노승무,홍기훈 최신의학사 1997 最新醫學 Vol.40 No.7

유년형 난소 과립막 세포종 2예

어완규,김흥열,김홍배 고신대학교 의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

난소의 성기삭-간질 종양은 전체 난소 종양의 약 5~8% 를 차지하는 드문 종양으로서 그 중 약 70%는 과립막 세포종이다. 대부분 30세 이전에 발생하는 유년형 과립막 세포종은 전형적인 성인형 과립막 세포종에 비해서 임상적 및 병리학적 측면에서 매우 다른 양상을 나타낸다. 유년형 과립막 세포종은 대부분 좋은 예후를 나타내지만, 종양이 진행된 경우에는 병기, 종양의 크기, 피막 파열 여부, 핵의 비정형 정도, 유사분열 정도와 관련되어 나쁜 임상적 예후를 나타낸다. 유년형 과립막 세포종은 병기가 낮은 경우 수술이 최상의 치료 방법이지만, 병기가 높거나 재발된 종양에 대한 치료 방법은 아직 명확하지 않다. 저자들은 난소의 유년형 과립막 세포종 2예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Sex cord-stromal tumors of the ovary are rare neoplasms that account for about 5~8% of all ovarian malignancies, and about 70% of those are granulosa cell tumors. Juvenile granulosa cell tumor (JGCT), which occurs most frequently in the first two decades, has distinct differences from adult granulosa cell tumor (AGCT) with regard to clinical and pathological features. The prognosis of JGCT in children is good in most cases, but tumor with more advanced disease has worse clinical outcome correlated with its stage, tumor size, presence of ruptures, grade of nuclear atypia, and degree of mitotic activity. The best treatment choice for low stage JGCT is surgery, but those for advanced stage JGCT or recurrent tumor have not yet been determined clearly. We present two cases of JGCT with brief review of literatures.

위암환자에서 수용성 Intercellular Adhesion Molecule-1의 의의

배진선,송인상,김완식 한국의학사 1999 診斷과治療 Vol.19 No.8

폐경기 자궁 액체 축척 여성에서 자궁두께에 따른 조직학적 소견

김흥열,김흥배,어완규 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2

Objectives : The aim of the study was to assess the hitologic appearance according to endometrial thickness in postmenopausa endometrial fluid accumulation women. Methods : A group of 20 postmenopausal women with an endometrial fluid accumulation confirmed by ultrasonography and underwent Dilatation & Curettage. The patients were divided into two groups according to the endometrial thickness(ET). Sixteen women had thin endometrium (<4mm) and four women had the thick endometrium (≥4mm). Results : When ET was ≥ 4mm, proliferative endometrium was found in 2 patients (50%), atrophic endometrium was in I patient (25%) and endometritis was in I patient (25%). When ET was < 4mm, atrophic endometrium was found in 14 patients (87%), A majority of patients with ET of less than 4mm in ultrasound had atrophic endometrium. The incidence of intrauterine pathology increased with the increasing thickness of endometrium as abserved by ultrasound. Conclusion : The presence of endometrial fluid accumulation in postmenopausal patients without any symptoms seems to be a benign condition. Normal endometrium of less than 4mm observed by ultrasound in postmenopausal women without vaginal bleeding dose not necessarily need further surgical investigation.