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- 저자 : ( Tomoko Ishikawa ) (검색결과 4 건)
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Difficulties faced by children with disabilities and their families in the event of a disaster
KOBAYASHI Tomoko,ISHIKAWA Rei,OISHI Hirofumi 아시아장애사회학회 2011 아시아장애사회학연구 Vol.11 No.-
It is necessary to shed light on difficulties faced by parents in the event of a disaster We studied that was to shed light on the difficulties faced by the parents of disabled children in the event of a disaster. The results showed that “home" was seleded by the highest number of respondents as shelter life place, followed by "car". On the other hand, number of users of "regional evacuation center" was 1/3 rd of that of “ home 씨 and around 2/3 rd of that of “car. Establis hment of such evacuation centers with much beUer support facilities compared to ordinary evacuation centers to ensure that disabled children , disabled people and their family need not live at home or in car feeling unsecured and unsafe, is extremely beneficial ‘
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Inhibitory Effect of Honeybee-Collected Pollen on Mast Cell Degranulation In Vivo and In Vitro
Yasuko Ishikawa,Tomoko Tokura,Nobuhiro Nakano,Mutsuko Hara,Fran?is Niyonsaba,Hiroko Ushio,Yuji Yamamoto,Tadahiro Tadokoro,Ko Okumura,Hideoki Ogawa 한국식품영양과학회 2008 Journal of medicinal food Vol.11 No.1
Bee-collected pollen (bee pollen [BP]) has been used as a folk medicine for centuries against various diseases,including allergy. There is no study elucidating how BP exerts such an anti-allergic effect. Since mast cells play a central rolein the pathogenesis of various allergic diseases, we investigated the effect of BP on mast cell activation elicited by the Fc im-munoglobulin E (IgE) receptor (Fc.RI)-mediated pathways. The in vivo effect of orally administered BP on cutaneous mastcell activation was examined by passive cutaneous anaphylaxis reaction. In vitromast cell degranulation and IgE binding tomast cells and the status of protein tyrosine phosphorylation were examined using bone marrow-derived mast cells. Daily oraladministration of BP to mice significantly reduced the cutaneous mast cell activation elicited by IgE and specific antigens.BP also reduced in vitromast cell degranulation and tumor necrosis factor-. production by inhibiting IgE binding to Fc.RIon mast cells. The inhibitory effect of BP on mast cell degranulation by preventing IgE binding was confirmed by the re-duced levels of protein tyrosine phosphorylation, which occurred as downstream events in activated mast cells via Fc.RI.These results first revealed that the anti-allergic action of BP was exerted by inhibiting the Fc.RI-mediated activation of mastcells, which plays important roles, not only in the early phase, but also in the late phase of allergic reactions.
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Therapeutic Potential of Natural Product-Based Oral Nanomedicines for Stroke Prevention
Tatsushi Mutoh,Tomoko Mutoh,Yasuyuki Taki,Tatsuya Ishikawa 한국식품영양과학회 2016 Journal of medicinal food Vol.19 No.6
Cerebral stroke is the leading cause of death and permanent disability in elderly persons. The impaired glucose and oxygen transport to the brain during ischemia causes bioenergetic failure, leading to oxidative stress, inflammation, bloodbrain barrier dysfunction, and eventually cell death. However, the development of effective therapies against stroke has been hampered by insufficient oral absorption of pharmaceuticals and subsequent delivery to the brain. Nanotechnology has emerged as a new method of treating cerebral diseases, with the potential to fundamentally change currently available therapeutic approaches using compounds with low bioavailability. This perspective review provides an overview of the therapeutic potential of oral nanomedicines for stroke, focusing on novel natural product-loaded delivery system with potent antioxidant and anti-inflammatory effects.
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Identification of a New Race and Development of DNA Markers Associated with Powdery Mildew in Melon
( Hoy Taek Kim ),( Jong In Park ),( Arif Hasan Khan Robin ),( Tomoko Ishikawa ),( Maki Kuzuya ),( Manabu Horii ),( Katsutoshi Yashiro ),( Ill Sup Nou ) 한국육종학회 2016 Plant Breeding and Biotechnology Vol.4 No.2
Powdery mildew disease caused by an obligatory parasitic fungus Podosphaera xanthii is a serious problem of melon (Cucumis melo L.) production worldwide. Severity of problem is further associated with emergence of new races over the years. In this study a new race of powdery mildew fungus was discovered from Ibaraki, Japan. The race was different from all other existing races of P. xanthii occurring in Japan. Phenotypic and genetic analysis established the new fungus type as a new race, N5. Ten melon lines were infected with a total of eight fungal races including the new N5 race and it was found that all melon lines had different disease reactions against the new race compared to other seven races. Only four melon genotypes were found resistant out of 42 commercial cultivars and lines were tested. Disease reactions of two sets of F2 populations and one set of backcross population revealed that two separate epistatic gene loci located in two different linkage groups (LG), LG II and LG XII, interact together for the resistant or susceptible reaction of melon lines. A total of six simple sequence repeat (SSR) markers were found polymorphic in melon lines out of 16 tested in response to N5 race. Two different sets of F2 populations between resistant and susceptible melon lines were assessed with two polymorphic SSR markers located in two different groups, LG II and LG XII. SSR genotyping yielded 78% and 94% expected polymerase chain reaction fragments in favor of resistance or susceptibility of F2 populations of CM17187×PMR5 and PMR45×PMR5 of melon lines, respectively.
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