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( Sawako Kuruma ),( Terumi Kamisawa ),( Taku Tabata ),( Seiichi Hara ),( Takashi Fujiwara ),( Go Kuwata ),( Hideto Egarashira ),( Koichi Koizumi ),( Keigo Setoguchi ),( Junko Fujiwara ),( Takeo Arakaw 대한소화기학회 2013 Gut and Liver Vol.7 No.1
Background/Aims: The objective of this study was to compare the clinical characteristics of patients with autoimmune pancreatitis (AIP) with or without Mikulicz`s disease (MD) and with MD alone. Methods: We investigated the clinical findings in 15 AIP patients with MD (group A+M), 49 AIP only patients (group A), and 14 MD only patients (group M). Results: The male-female ratio was significantly higher in group A+M (73%, p<0.05) and group A (78%, p<0.01) than group M (21%). Serum immunoglobulin G (IgG) levels were significantly higher in group A+M than in group A (p<0.01) and group M (p<0.05). Serum IgG4 levels were significantly higher in group A+M than in group A (p<0.01). Other organ involvement was observed in 73% (11/15) of patients in group A+M. The number of patients with diabetes mellitus was significantly higher in group A+M (66%, p<0.01) and group A (51%, p<0.05) than in group M (7%). All of the patients responded well to steroid therapy, but the relapse rate in group A+M (33%) was significantly higher than that in group A (3%, p<0.01). Salivary gland function was impaired in all groups compared with the control group, but the degree of dysfunction was less in group A compared with group A+M and group M. Conclusions: The relapse rate of AIP in MD patients was significantly higher than that of AIP in patients without MD. (Gut Liver 2013;7:96-99)