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Gliotoxin ameliorates TNBS-induced colitis through regulation of NF-kB, and up-regulation of HO-1
김상욱 ( Kim Sang Ug ),( Jay Min Oh ),( Yeon Hwa Kim ),( Jung Moo Hur ),( Kyo Sang Yoo ),( Yong Sung Kim ),( Joo Jin Yeom ),( Tae Hyeon Kim ),( Suck Chei Choi ),( Chang Duk Jun ),( Yong Ho Nah ) 대한소화기학회 2003 대한소화기학회 추계학술대회 Vol.2003 No.-
<Background & aims> During inflammation in colon, cells of the gut mucosa produce or express various inflammatory mediators, including IL-8, TNF-a and IL-1b, and intercellular adhesion molecule 1 (ICAM-1). These cytokines and chemokines have recently been
기관내 삽관이 어려웠던 폐동맥 sling을 동반한 기관협착 환아1예
염석란,신중호,신종환,이근,류일,현성열,진욱,김재광 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4
Pulmonary arterial sling, a rare developmental vascular anomaly forms a sling around the distal trachea and the proximal right main bronchus, where it sometimes makes tracheo-bronchial stenosis. Tracheo-bronchial stenosis from pulmonary arterial sling may produce non-specific symptoms of stridor, noisy breathing, dyspnea, recurrent upper respiratory tract infection, chronic cough, and dysphagia. The diagnosis of this anomaly begins with a high index of suspicion because of the lack of pathognomonic finding on usual evaluation. In this case, initial difficult intubation makes us evaluate further. Other cases reported the diagnosis is established by imaging studies, usually MRI and angiography. But, when our case was evaluated, we used cervico-thoracic enhanced computered tomography and tracheal fluoroscopy. Up to now, tracheobronchial stenosis from vascular anomaly is a rare and challenging disorder with a poor prognosis. However, early exact diagnosis would make us perform the accurate surgical treatment and reduce the mortality and morbidity.
대기압 플라즈마 처리를 통한 PU-g-PAAc Foam의 제조
염영호,명성운,최호석 한국화학공학회 2004 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.42 No.1
대기압 플라즈마 처리 및 AAc 그라프팅을 통해 PU foam(10PPI)의 표면을 개질 하였다. 대기압 플라즈마 처리로 PU foam의 표면에 peroxides를 충분히 생성시킨 후 AAc 액상 그라프팅 반응으로 carboxyl group을 갖는 PU foam을 제조하였다. PU foam에 많은 양의 peroxides를 도입하기 위해 플라즈마 rf-power와 처리 시간을 조절하여 AAc 그라프팅을 통한 GD의 변화로 최적 조건을 조사하였다. 대기압 플라즈마 반응기의 최적 조건은 GD의 변화를 통해 rf-power 100W, 처리시간 100초임을 알 수 있었다. 다음으로 다양한 그라프팅 조건(온도, 농도, 반응시간)에 따른 GD의 변화를 살펴보았다. GD는 온도가 올라감에 따라 대체적으로 증가하였고, 반응 시간이 증가함에 따라서는 3시간까지 증가하다가 그 후로는 일정한 값을 나타내었다. 또한 저 농도의 AAc에서는 GD가 상당히 낮았으며, 60-70%의 농도에서 최대값을 나타내었다. 개질된 PU foam의 carboxyl group들은 FT-IR을 이용하여 정성적으로 확인하였고, 정량적인 분석으로 무게측정법을 사용하였다. 또한 근접촬영사진을 통해 그라프팅 반응 전후에 나타난 PU foam 표면의 구조 변화를 살펴보았다. 끝으로, 난백에 있는 단백질과 Lysozyme을 PU foam 표면에 고정화시켜 이온교환수지로서의 가능성 여부를 평가하였다. We successfully modified the surface of PU(Polyurethane) foam(10 PPI) through atmospheric pressure plasma treatment and subsequent grafting of AAc(acrylic acid). The plasma treatment can generate large amount of peroxides on the surface of PU foam and the peroxide groups act as initiators for further grafting of AAc in the monomer solution. To introduce large amount of peroxides on the surface of PU foam, we studied the effect of plasma rf-power and treatment time on the maximum grafting of AAc. Through this study, we found that the optimum rf-power was 100W and the optimum treatment time was 100sec. On the other hand, we also studied the effect of graft reaction conditions such as temperature, monomer concentration and reaction time on the change of grafting degree(GD). The GD increased with temperature and increased with reaction time before it leveled off at 3hr after reaction. At low concentration of AAc, the GD was very low but it showed the maximum at the monomer concentration between 60% and 70%. The surface of the modified PU foam was qualitatively and after plasma induced graft co-polymerization through photo and SEM analysis. Finally, we confirmed the immobilization of Lysozyme through the electrophoresis analysis of proteins, which were recovered by the PY-g-PAAc foam from egg white.
김상욱,김윤호,김진호,염상민 강원대학교 정보통신연구소 2000 정보통신논문지 Vol.4 No.-
In this paper, we discuss the experiences obtained in developing the index manager of the Tachyon, a next-generation main memory DBMS(MMDBMS). The index manager is an essential sub-component of the DBMS used to speed up the retrieval of objects from a large volume of a database in response to a certain search condition. Previous research efforts on indexing proposed various index structures. However, they hardly dealt with the practical issues occurred in implimenting an index manager on a target DBMS. In this paper, we touch these issues and present our experiences in developing the index manager on the Tachyon as solutions. The issues mainly touched are (1) compact representation of an index entry, (2) support of variable-length keys, (3) support of multiple-attribute keys. (4) support of duplicated keys, (5) concurrency control, and (6) backup and recovery. We believe that our contribution would help MMDBMS developers highly reduce their trial-and-errors.
김상욱,장연정,염상민,김윤호 江原大學校 産業技術硏究所 1998 産業技術硏究 Vol.18 No.-
The deadlock detector is a DBMS sub-component that examines periodically whether system is in a deadlock state based on lock waiting information of transactions. The deadlock detector and transactions execute concurrently in a DBMS and read and /or write the lock waiting information simultaneously. Since the lock waiting information is a shared one, we need an efficient method guaranteeing its physical consistency by using mutual exclusion. In this paper, we propose a new method that effectively guarantees physical consistency of lock waiting information. Two primary goals of our method is to minimize the processing overhead and to maximize system concurrency.
대형 화재로 인한 사상자의 손상 유형과 합병증 : 동인천 라이브호프 화재를 중심으로
신중호,김재광,염석란,신종환,민순식,임용수,양혁준,이근,황성연 대한응급의학회 2001 대한응급의학회지 Vol.12 No.3
Background: High risks of fire alway exist for buildings in urban areas, especially those in downtown. Crowds, as well as more complex and larger structures, may cause more victims in the event of fire; therefore, emergency medical service plans must be established for such disastrous events. Methods: On the evening of October 30,1999, a fire broke out in downtown, Dong-Incheon Live-Hof restaurant; 56 people were killed and 76 were injured. Most of them were teenagers. We retrospectively reviewed the medical records of the victims, Results: 1) Among the 56 dead, 54 died from smoke inhalation, one from extensive burns, and one from sepsis during treatment. 2) Among the 76 injured, 70 patients suffered from smoke inhalation, 53 from burns, and 9 from several types of trauma (sprains, contusions, lacerations, abrasions, fractures, etc.). 3) Later complications were laryngeal edema, pulmonary edema, scar contracture, and hypoxic brain damage, and so forth. 4) Post traumatic stress syndrome was unexpectedly more prevalent in mildly to moderately injured survivors and witnesses than in seriously injured survivors. Conclusion: Many complications exist after a fire. Some may be resolved in time, but others may result in permanent sequelae. Early rescue, early triage, and early management during transport by emergency medical service (EMS) personnel can result in fewer complications and a lower mortality rate. Therefore, we propose the establishment of plans to be followed during various major disasters.
Two-step bioprocess employing whole cell and enzyme for economical biodiesel production
Sung Ho Yeom†,Dong Jin Jeon 한국화학공학회 2010 Korean Journal of Chemical Engineering Vol.27 No.5
A preliminary research for feasible and economical bioprocess for biodiesel production was carried out. A microorganism producing lipase was isolated from grease-contaminated soil. After chemically mutating twice, the microorganism exhibited 2.5 times higher intracellular lipase activities than wild type one and was used as a whole cell biocatalyst for biodiesel production. 0.1% toluene treatment followed by freeze drying was the optimum preparation method for whole cell biocatalyst. 1 g whole cell biocatalyst corresponded to 0.15 g commercial enzyme under mild methanol inhibition condition, while corresponding to 0.7 g enzyme under severe methanol inhibition environment. A two-step process, biodiesel production by the whole cell and sequentially by commercial enzyme, was suggested. This novel process, combining the advantages of whole cell and enzyme, saved the usage of commercial enzyme and alleviated enzyme deactivation by methanol.