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( Graciella Wahjoepramono ),( Franxicus Clinton ),( Shirley Ivone Moningkey ),( Wahyuni Lukita Atmodjo ),( George Mathew ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Hepatitis B viral infection is estimated more than one third of the world`s population and 5% of all carriers develop cirrhosis, and primary hepatocellular carcinoma. Our previous epidemiology study of prevalence Hepatitis B infection in rural areas of Tangerang regency showed about 3. 96% were positive to HBsAg test. Serologic test used for the diagnosis of Hepatitis B virus infection involves of distinct HBV-specifi c antigens and host antibody react to these antigens, however the interpretation of these tests was complicated and refi ects multiple possibilities. Methods: five hundred patients visited Rural Health Community Centers were recruited with inclusion criteria age 15 - 60 years old male or female, they do not drink alcohol and they have no history of jaundice. Their plasma was screened for HbsAg using ELISA and Rapid Diagnostic tests; then those blood demonstrated positive to HbsAg, subsequently tested for anti-HBs, anti-HBc, HBeAg, anti-HBe and HBV DNA viral load. Results: The blood of nineteen (19) patients showed positive to HBsAg. Serologic test for anti-HBs was negative, but all of 19 showed positive to anti-HBc. Only 2 patients were detected HBeAg-positive but anti-HBe react either positive or negative. Measurement viral load of HBV-DNA demonstrated the number < 1, 000 IU/ml for 16 patients and 3 patients the number > 10, 000 IU/ml. Conclusions: Serologic profi les of 19 patients with HBsAg-pos are consistent with carrier state or chronic hepatitis B infection, however only 3 patients with higher HBV DNA levels (>10. 000 IU/ml) were diagnosed as Chronic Hepatitis B infection. Mostly patients were diagnosed as carrier state due to their serologic profi le of HBeAg-negative and anti Hbe positive or negative with viral load less than 1000 IU/ml.
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