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      • Adipocyte-Derived FABP4 Regulates of Cancer Stemness and Drug Resistance in Hepatocellular Carcinoma

        ( Shilpa Gurung ),( Terence Kin-wah Lee ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

        Aims: Hepatocellular carcinoma (HCC) is one of the deadliest cancers in the world. Increasing reports showed significant correlation between non-alcoholic fatty liver disease (NAFLD) and HCC development. Given cancer stem cells (CSCs) play a critical role in regulating the tumor relapse and therapeutic resistance, we hypothesize that adipocytes, one of the key cellular factors within the tumor microenvironment, may play a critical role in HCC pathogenesis via regulation of liver CSCs. Methods: We have employed a co-culture system to dissect the potential cross-talk between fully differentiated adipocytes and HCC cells. The conditioned medium (CM) of adipocytes was collected to examine the potential paracrine effect of adipocytes in regulating liver CSCs. The secretome of adipocytes was analyzed by using Orbitrap Liquid Chromatography-Mass spectrometry. Molecular pathway mediating the phenotypic alterations was identified through RNA sequencing analysis and functional rescue experiments. Results: Using co-culture system, we found that adipocytes enhanced the self-renewal and tumorigenicity of HCC cells through paracrine secretion. Consistently, conditioned medium of adipocytes showed enhanced tumorigenicity, self-renewal, invasiveness and resistance to doxorubicin and sorafenib treatment. By Orbitrap Liquid Chromatography-Mass spectrometry, we identified 209 proteins, among which we have focused on FABP4 as it is preferentially secreted from adipocytes. Consistently, recombinant FABP4 enhanced CSC properties of HCC cells; while FABP4 inhibitor (BMS309403) abolished the CSC enhancing effect of CM of adipocytes. Clinically, FABP4 overexpression was significantly correlated with poorer patients survival. Conclusions: We demonstrated the pivotal role of adipocytes on regulation of liver CSCs through paracrine secretion. Adipocyte-derived FABP4 signaling cascade may be a novel therapeutic target for treatment of NAFLD induced HCC.

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