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      • The Korean Society of Gastroenterology & SIDDS 2039 : Slide Session ; S-LI-04 : Liver ; Clostridium Diffi cile Associated Diarrhea in Liver Cirrhosis Patients: Incidence and Risk Factor

        ( Andree Kurniawan ),( Nata Pratama Hardjo Lugito ),( Margaret Merlyn Tjiang ),( Theo Audi Yanto ),( Lilia Angela ),( Ernestine Vivi Sadeli ),( Shia Elizabeth Ariel Setiawan ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

        Background: One third of all patients hospitalized with cirrhosis have at least oneinfection during hospitalization and one of etiology was C. diffi cile infection. Those infection could increase length of stay and mortality. There is still limited data exploring those problems. The aim of this study to know characteristic and risk factor of C. diffi cile associated diarrhea infection in liver cirrhosis patients. Methods: This cross-sectional study was conducted in Internal medicine ward at General hospital, Karawaci, Tangerang, Banten, Indonesia from May 2013 until April 2014. The inclusion criteria are adult patients diagnosed having cirrhosis by abdominal ultrasound. The exclusion criteria were pregnant woman and having C. diffi cile infection before. Their feces were checked for C. diffi cile antigen and toxin using C. Diff complete quick check. All of subject then divided into 2 groups if they having nosocomial diarrhea and all were analyzed using Pearson Chi Square. Results: Of 55 patient subjects, there were 35 males and 20 females. Median age was 51 (16-79) year old. The etiology of liver cirrhosis was 52.7% hepatitis B, 7.3% hepatitis C and the others undefi ned. The most common degree of liver cirrhosis was 67.3% child Pugh B. About 14.5% subject had nosocomial diarrhea. All those subjects had positive for antigen and toxin C. diffi cile. From 14.5% those patients, 25.5% had history antibiotic consumption, 23.6% had history of hospitalization and 20% had history using proton pump inhibitor in the last 3 months. Unfortunately, There were no statistically signifi cant related to those potential risk factors. Conclusions: The incidence of C. diffi cile infection associated diarrhea in liver cirrhosis patients was 14.5%. The potential risk factors were history of antibiotic, proton pump inhibitor usage, and hospitalization in last 3 months.

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