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Xiaoqing ZHAO(Xiaoqing ZHAO),Qingbang MU(Qingbang MU),Brian Sheng-Xian TEO(Brian Sheng-Xian TEO ) 한국유통과학회 2023 The Journal of Asian Finance, Economics and Busine Vol.10 No.1
This paper investigates the effect of independent directorship on the firm performance of Chinese listed companies under the impact of the global COVID-19 epidemic. The study starts by assessing the relationship between independent director-related characteristics and firm performance, then mines independent director characteristics variables, collects variable data, proposes reasonable hypotheses, and constructs a data model. 1597 companies listed on Shanghai and Shenzhen stock index, China, from 2020 to 2021 has been selected as the research sample. An empirical study on the relationship between independent directors’ characteristics and firm performance was conducted using SPSS25. The results show that under the impact of the global COVID-19 epidemic, the proportion of independent directors on the board of directors, the age of independent directors, the remuneration of independent directors, and the overseas background of independent directors in Chinese listed companies have a negative relationship with the current firm performance, while the proportion of female independent directors and the part-time rate of independent directors do not have a positive effect on firm performance. The findings of this study strongly imply that independent directors’ characteristics play a significant role in corporate governance and firm performance in Chinese listed companies and that the external environment has an impact on how well independent directors can carry out their duties.
Zhao, Shengli,Ting, Jonathan T,Atallah, Hisham E,Qiu, Li,Tan, Jie,Gloss, Bernd,Augustine, George J,Deisseroth, Karl,Luo, Minmin,Graybiel, Ann M,Feng, Guoping Nature Publishing Group, a division of Macmillan P 2011 Nature methods Vol.8 No.9
Optogenetic methods have emerged as powerful tools for dissecting neural circuit connectivity, function and dysfunction. We used a bacterial artificial chromosome (BAC) transgenic strategy to express the H134R variant of channelrhodopsin-2, ChR2(H134R), under the control of cell type??specific promoter elements. We performed an extensive functional characterization of the newly established VGAT-ChR2(H134R)-EYFP, ChAT-ChR2(H134R)-EYFP, Tph2-ChR2(H134R)-EYFP and Pvalb(H134R)-ChR2-EYFP BAC transgenic mouse lines and demonstrate the utility of these lines for precisely controlling action-potential firing of GABAergic, cholinergic, serotonergic and parvalbumin-expressing neuron subsets using blue light. This resource of cell type??specific ChR2(H134R) mouse lines will facilitate the precise mapping of neuronal connectivity and the dissection of the neural basis of behavior.
Research on Computer Network Virus Defense Technology in Cloud Technology Environmen
Zhao Sheng,Han HuiShan,Shi XueKui 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.3
With the rapid development of the Internet, the antivirus software of the network is always emerging and constantly changing. Traditional detection methods can’t effectively kill the new viruses and malicious software, the complexity of which also makes itself easy to be attacked by malicious software. The emergence of cloud computing has changed the status quo. Therefore, the architecture model of virus malware detection based on cloud computing is proposed in this paper. Based on the combination of the method for detecting malicious software virus based on cloud computing and the algorithm analysis theory in machine learning, a new type of distributed CFO algorithm is proposed, and the closed environment of cloud computing virtual machine nodes is used to realize dynamic behavior monitoring to the virus malware, then the distributed fluctuations PIF algorithm is used to describe the process of dynamic analysis and analysis reporting, besides, the wave algorithm is carried out corresponding improvement based on the analysis of the environment. Experimental results show that the model can detect the conditional trigger behavior of virus malware, so as to find the conditions for triggering malicious behavior and the input data that satisfy these conditions and the performance of this monitoring system is greatly improved compared with the common single machine system.
Research on Data Intrusion Detection Technology based on Fuzzy Algorithm
Sheng Zhao,Huishan Han,Xuekui Shi 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.8
The computer system is becoming more complex and massive network data, which brings great difficulties to the traditional intrusion detection system. Intrusion detection system is an important part of the network and information security architecture, which is mainly used to distinguish the normal activities of the system and the suspicious and intrusion patterns. But the challenge is how to effectively detect network intrusion behavior in order to reduce the false alarm rate and false negative rate. Based on the shortcomings of existing intrusion detection methods, the fuzzy C- means clustering method is proposed to analyze the intrusion detection data, so as to find out the abnormal network behavior patterns. By testing the CUP99 data set, the results show that the IFCA is not only feasible but also accurate and efficient. The improved fuzzy clustering algorithm proposed in this paper can improve the detection rate of intrusion detection and reduce the false detection rate, and can be widely used in intrusion detection system.
Synthesis and Cytotoxicity of Novel 3-Amino-4-indolylmaleimide Derivatives
Sheng-Yin Zhao,Yan-Wu Yang,Hai-Quan Zhang,Yun Yue,Mei Fan 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.4
In an attempt to develop potent and selective antitumor agents, a series of novel 3-amino-4-indolylmaleimides were designed and synthesized. The reaction showed high regioselectivity. The structure of compound 7a was determined by an X-ray single crystal diffraction method. The cytotoxicities of the title compounds were evaluated against HeLa, SMMC 7721 and HL 60 cancer cell lines by a standard MTT assay in vitro. The pharmacological results showed that some of the title compounds displayed moderate or high cytotoxic activity against the tested cell lines. Compound 7d was the most promising compound against the tested cancer cell lines. Structure-activity relationships are discussed based on the experimental data obtained. A hydroxyethylamino group at the 3-position in the side chain of indolylmaleimide is associated with an increase in cytotoxicity.
Zhao, Bao-Sheng,Liu, Shang-Guo,Wang, Tian-Yun,Ji, Ying-Hua,Qi, Bo,Tao, Yi-Peng,Li, Han-Chen,Wu, Xiang-Nan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.1
Patients at the same pathological stage of esophageal cancer (EC) that received the same surgical therapy by the same surgeon may have distinct prognoses. The current study aimed to explore the possibility of differentially-expressed microRNAs (miRNAs) underlying this phenomenon. Samples were collected from EC patients at the same tumor node metastasis (TNM) stage but with different prognoses. Paracancerous normal tissues were taken as controls. The specimens were histopathologically analyzed. Differentially-expressed miRNAs were analyzed using real-time quantitative reverse transcription polymerase chain reaction. Compared with patients with poor prognosis, those with good prognosis exhibited 88 two-fold or more than two-fold increased miRNA fragments and 4 half-decreased miRNAs. The most noticeably up-regulated miRNAs included hsa-miR-31, hsa-miR-196b, hsa-miR-652, hsa-miR-125a-5p, hsa-miR-146b, hsa-miR-200c, hsa-miR-23b, hsa-miR-29a, hsa-miR-186, hsa-miR-205, hsa-miR-376a, hsa-miR-410, hsa-miR-532-3p, and hsa-miR-598, whereas the most significantly-downregulated miRNAs were hsa-let-7e, hsa-miR-130b, and hsa-miR-103. EC patients at same TNM stage but with different prognoses show differentially-expressed miRNAs.
MiR-182-5p Knockdown Targeting PTEN Inhibits Cell Proliferation and Invasion of Breast Cancer Cells
Yue-Sheng Zhao,Wei-Chao Yang,Hong-Wei Xin,Ji-Xia Han,Su-Gang Ma 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.2
Purpose: Breast cancer (BC) is one of the most common malignant tumors, affecting a significant number of women worldwide. MicroRNAs (miRNAs) have been reported to play important roles in tumorigenesis. The aim of this study was to determine theroles of miR-182-5p in BC progression. Materials and Methods: The expressions of miR-182-5p and phosphatase and tensin homolog deleted on chromosome 10(PTEN) were measured in BC tissues and cells by quantitative real-time polymerase chain reaction or Western blot. Cell proliferationand invasion were detected by cell counting kit-8 assay and trans-well assay, respectively. The interaction between miR-182-5p and PTEN was probed by bioinformatics analysis, luciferase activity, and RNA immunoprecipitation. A murine xenograftmodel was established to investigate the role of miR-182-5p in BC progression in vivo. Results: An abundance of miR-182-5p was noted in BC tissues and cells. High expression of miR-182-5p was associated with poorsurvival. Abrogation of miR-182-5p inhibited cell proliferation and invasion in BC cells. Interestingly, PTEN was indicated as atarget of miR-182-5p, and its restoration reversed miR-182-5p-mediated promotion of proliferation and invasion of BC cells. Moreover, depletion of miR-182-5p suppressed tumor growth via up-regulating PTEN expression in the murine xenograft model. Conclusion: MiR-182-5p exhaustion blocked cell proliferation and invasion by regulating PTEN expression, providing a noveltherapeutic avenue for treatment of BC.