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RISS 인기검색어
- 검색키워드
- 저자 : ( Saori Minato ) (검색결과 2 건)
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Keiji Hirai,Saori Minato,Shohei Kaneko,Katsunori Yanai,Hiroki Ishii,Taisuke Kitano,Mitsutoshi Shindo,Haruhisa Miyazawa,Kiyonori Ito,Yuichirou Ueda,Yoshio Kaku,Taro Hoshino,Tatsuro Watano,Shinji Fujino 대한신장학회 2019 Kidney Research and Clinical Practice Vol.38 No.3
Background: We investigated the relationship between serum total carbon dioxide (CO2) and bicarbonate ion (HCO3 -) concentrations in pre-dialysis chronic kidney disease (CKD) patients and devised a formula for predicting low bicarbonate (HCO3 - < 24 mmol/L) and high bicarbonate (HCO3 - ≥ 24 mmol/L) using clinical parameters. Methods: In total, 305 samples of venous blood collected from 207 pre-dialysis patients assessed by CKD stage (G1 + G2, 46; G3, 50; G4, 51; G5, 60) were investigated. The relationship between serum total CO2 and HCO3 - concentrations was analyzed using Pearson’s correlation coefficient. An approximation formula was developed using clinical parameters correlated independently with HCO3 - concentration. Diagnostic accuracy of serum total CO2 and the approximation formula was evaluated by receiver operating characteristic curve analysis and a 2 × 2 table. Results: Serum total CO2 correlated strongly with HCO3 - concentration (r = 0.91; P < 0.001). The following approximation formula was obtained by a multiple linear regression analysis: HCO3 - (mmol/L) = total CO2 - 0.5 × albumin - 0.1 × chloride - 0.01 × (estimated glomerular filtration rate + blood glucose) + 15. The areas under the curves of serum total CO2 and the approximation formula for detection of low bicarbonate and high bicarbonate were 0.981, 0.996, 0.993, and 1.000, respectively. This formula had superior diagnostic accuracy compared with that of serum total CO2 (86.6% vs. 81.3%). Conclusion: Serum total CO2 correlated strongly with HCO3 - concentration in pre-dialysis CKD patients. An approximation formula including serum total CO2 showed superior diagnostic accuracy for low and high bicarbonate compared with serum total CO2.
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( Keiji Hirai ),( Susumu Ookawara ),( Junki Morino ),( Saori Minato ),( Shohei Kaneko ),( Katsunori Yanai ),( Hiroki Ishii ),( Momoko Matsuyama ),( Taisuke Kitano ),( Mitsutoshi Shindo ),( Haruhisa Mi 대한신장학회 2020 Kidney Research and Clinical Practice Vol.39 No.4
Background: Few studies have investigated the relationship between serum total carbon dioxide (CO<sub>2</sub>) concentration and bicarbonate ion (HCO<sub>3</sub> <sup>-</sup>) concentration in patients undergoing hemodialysis. We determined the agreement and discrepancy between serum total CO<sub>2</sub> and HCO<sub>3</sub> <sup>-</sup> concentrations and the diagnostic accuracy of serum total CO<sub>2</sub> for the prediction of low (HCO<sub>3</sub> <sup>-</sup> < 24 mEq/L) and high (HCO<sub>3</sub> <sup>-</sup> ≥ 24 mEq/L) bicarbonate concentrations in hemodialysis patients. Methods: One hundred forty-nine arteriovenous blood samples from 84 hemodialysis patients were studied. Multiple linear regression analysis was used to determine factors correlated with HCO<sub>3</sub> <sup>-</sup> concentration. Diagnostic accuracy of serum total CO<sub>2</sub> was evaluated using receiver operating characteristic curve analysis and a 2 × 2 table. Agreement between serum total CO<sub>2</sub> and HCO<sub>3</sub> <sup>-</sup> concentrations was assessed using Bland-Altman analysis. Results: Serum total CO<sub>2</sub> concentration was closely correlated with HCO<sub>3</sub> <sup>-</sup> concentration (β = 0.858, P < 0.001). Area under the curve of serum total CO<sub>2</sub> for the identification of low and high bicarbonate concentrations was 0.989. Use of serum total CO<sub>2</sub> to predict low and high bicarbonate concentrations had a sensitivity of 100%, specificity of 50.0%, positive predictive value of 96.5%, negative predictive value of 100%, and accuracy of 96.6%. Bland-Altman analysis showed moderate agreement between serum total CO<sub>2</sub> and HCO<sub>3</sub> <sup>-</sup> concentrations. Discrepancies between HCO<sub>3</sub> <sup>-</sup> and serum total CO<sub>2</sub> concentrations (serum total CO<sub>2</sub> - HCO<sub>3</sub> <sup>-</sup> ≤ -1) were observed in 89 samples. Conclusion: Serum total CO<sub>2</sub> concentration is closely correlated with HCO<sub>3</sub> <sup>-</sup> concentration in hemodialysis patients. However, there is a non-negligible discrepancy between serum total CO<sub>2</sub> and HCO<sub>3</sub> <sup>-</sup> concentrations.
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