http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : ( Sagar Lavenia ) (검색결과 5 건)
- 무료
- 기관 내 무료
- 유료
-
( Pardeep Kumar ),( Sagar Lavenia ),( Vk Sharma ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Free radical production and oxidative stress are known to increase in liver during aging, and may contribute to the oxidative damage. These changes increase during menopausal condition in females when the level of estradiol is decreased. The objective of this study was to observe the changes in activities of membrane linked ATPases antioxidant enzymes, hepatic enzymes, lipid peroxidation levels and glucose transporters 2 (GLUT 2) expression occurring in livers of female rats of 3, 12 and 24 months age groups, and to see whether these changes are restored to 3 months control levels rats after exogenous administration of 17-ß-estradiol (E2). Methods: The aged female rats (12 and 24 months old) (n=8 for each group) were given subcutaneous injection of 17ß estradiol (0.1 μg/g body weight) daily for one month. Controls animals received an equal volume of vehicle. After 30 days of hormone treatment, experimental animals of all the groups were sacrificed and livers were isolated for further study. Biochemical parameters including serum transaminases [aspartate aminotransferase (AST) and alanine aminotransferase (ALT)] and alkaline phosphatase (ALP) in serum were analyzed. A detailed study was carried on membrane linked enzymes (Na<sup>+</sup> / K<sup>+</sup> ATPase, Ca<sup>2+</sup> ATPase), antioxidant enzymes (superoxide dismutase, glutathione-S-transferase) and GLUT2 expression with immunohistochemistry to identify the antiaging role of E2 using biochemical, molecular and histochemical study. Results: The results obtained in the present work revealed that normal aging was associated with significant decrease in the activities of membrane linked ATPases, antioxidant enzymes, GLUT 2 expression and an increase in lipid peroxidation and hepatic enzymes in livers of aging female rats. Our data showed that exogenous administration of E2 brought these changes to near normalcy in aging female rats. Conclusions: The present study showed that E2 treatment reversed the changes to normal levels. E2 treatment may be beneficial in preventing some of the age related changes in the liver by increasing antioxidant defenses.
-
-
-
Role of Wearable Technology on Chronic Liver Disease in Type 2 Diabetic Patients
( Vikas Sharma ),( Sagar Lavenia ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: New wearable sensor networks together with smartphone applications are being examined and tested for their potential to monitor and manage chronic liver disease (CLD) in type 2 diabetic patients. To develop methods for analyzes and monitor of map the intersection(s) of hepatology data in relation to CLD via wearable technology (MI band and Yu band). To study effects of daily life routine activities on data by a wearable devices that can obtain real-time CLD data, help technologists understand medical aspects, and clinicians to understand technological processes them and provides assistance based on pre-determined specifications in CLD in type 2 diabetic patients in Agra city, India. Methods: Total of 106 CLD with type 2 diabetes patients were taken as subject with an equal ratio of male and female. Wearable monitoring devices were put on the wrist of CLD patients for 30 days and a questionnaire was filled out by each patient. Both diabetes and cardiovascular disease in turn are known as important factors for developing CLD and aggravation toward once end-stage liverl disease. In all subjects, blood glucose was measured on daily basis with day to day data of their monitoring of step count (deep sleep, light sleep, wake up time), blood pressure, calorie burnt, insulin dose, motion time i.e. every time when your body was in motion, sleep monitoring, monitoring heart rate, cardiac arrhythmias to know daily routines and recording them for health purpose. Results: Present results shown that both wearable device reading showed there was a normal heart rate, more calorie burnt with better control of sugar control and average good sleep count in more physically workout, include walking in CLD patients compared to less physically workout CLD patients, identified by professional physiotherapists. Both device reading showed that after changing lifestyle routine among less physically active CLD patients, their post- CLD events normalize with less requirement of medicine and insulin injection dose. Conclusions: With this study we show that, by using, these wearable devices ensured online assistive feedback for CLD patients with type 2 diabetes is possible with their health awareness, exercising and motivate further studies.
-
( Pardeep Kumar ),( Sagar Lavenia ),( Vk Sharma ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Oxidative stress induced by toxicants is known to cause various complications in the liver. Herbal drug such as Liv.52 is found to have hepatoprotective effect. However, the biochemical mechanism involved in the Liv.52 DS mediated protection against toxicity is not well elucidated using suitable in vivo models. Paracetamol causes oxidative stress and dysfunction of the liver. This study was undertaken to evaluate the effects of the hydroalcoholic extract of Liv.52 DS on some biochemical and histopathological parameters of liver tissue in against paracetamol induced hepatic damage in rats. Methods: Wistar rats were orally administered with 2g/kg body weight Paracetamol. Vehicle (distilled water) and silymarin (50 mg/kg body weight) were used as the negative and positive control groups, respectively. Paracetamol -administered groups were treated with Liv 52 DS extract (100, 200, and 400 mg/kg). After 15 days of treatment, the blood specimens and liver samples were examined. Alteration in the levels of biochemical markers of hepatic damage like AST, ALT, ALP and lipid peroxides were tested, and phytochemical tests were also performed. Results: In Paracetamol -treated group, the levels of serum urea, high density lipoprotein (HDL), and liver superoxide dismutase (SOD), catalase (CAT), and vitamin C significantly decreased (P<0.05) compared to control. Also, in this group, serum triglyceride (TG), total cholesterol (TC), very low density lipoprotein cholesterol (VLDL), protein carbonyl (PC), malondialdehyde, tumor necrosis factor-alpha (TNF-α), and TNF-α gene expression significantly increased (P<0.05) as compared to the control (vehicle-treated rats). Treatment with Liv. 52 DS extract in a significant increase (P<0.05) in CAT, SOD, vitamin C, HDL and a significant decrease (P<0.05) in the level of urea, MDA, PC, TG, TC, VLDL, TNF-α protein, and the gene expression of TNF-α compared with test without treatment group. Histopathological evidence demonstrated that treatment with Liv.52 DS extract could decrease liver lymphocyte infiltration. Conclusions: The present study suggests that Liv. 52 DS extract possesses hepatoprotective activity. It could be an effective and promising preventive agent against Paracetamo-induced hepatotoxicity.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
