PPG 신호를 활용한 고 정확도 제 1심음 및 제 2심음 자동 식별 알고리즘 개발

이수민(S. M. Lee),김부성(B. S. Kim),정동화(D. H. Jung),임홍준(H, J. Lim),박희준(H. J. Park),웨이췬(Qun Wei) 한국재활복지공학회 2021 한국재활복지공학회 학술대회논문집 Vol.2021 No.4

Heart disease is reported as a leading reason that caused human death around world. For the early prevention, using stethoscope to detect abnormalities of the heart sound is one of the most effective method so far. However, because of the noise that inside and outside of the tube of the stethoscope, and sujective judgement devided by the docter will cause the misdiagnosis. To improve the accuracy of the auscultation, in this study, a high-accuracy S1 and S2 heart sound automatic identification algorithm using PPG signal was developed. Based on the 3rd Shannon Energy algorithm, the parameters of the start and end points of S1 and S2 of the hear sound were found. Also, the P-peak value of the PPG signal were extracted and used to find the relationship with the S2 peak. The developed algorithm was conducted a performance test experiment and the rate of identification was higher than the exist algorithm.

Human bone marrow-derived mesenchymal stromal cells expressing S-TRAIL as a cellular delivery vehicle for human glioma therapy.

Menon, Lata G,Kelly, Kathleen,Yang, Hong Wei,Kim, Seung-Ki,Black, Peter M,Carroll, Rona S AlphaMed Press 2009 Stem Cells Vol.27 No.9

<P>Glioblastoma is among the most aggressive and treatment resistant of all human cancers. Conventional therapeutic approaches are unsuccessful because of diffuse infiltrative invasion of glioma tumor cells into normal brain parenchyma. Stem cell-based therapies provide a promising approach for the treatment of malignant gliomas because of their migratory ability to invasive tumor cells. Our therapeutic strategy was to use human bone marrow-derived mesenchymal stromal cells (hMSCs) as a cellular vehicle for the targeted delivery and local production of the biologic agent tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) at the glioma tumor site. hMSCs were transduced with a lentivirus expressing secretable TRAIL (S-TRAIL) and mCherry (red fluorescent protein). Our results clearly demonstrate the retention of tumor tropic ability of hMSC S-TRAIL cells by in vitro and in vivo migration assays. In vitro assays confirmed the expression, release, and biological activity of S-TRAIL produced by hMSC S-TRAIL cells. For the in vivo assessment of therapeutic efficacy, hMSCs were injected ipsilateral to an established intracranial glioma tumor in a mouse xenograft model. Genetically engineered hMSC S-TRAIL cells were effective in inhibiting intracranial U87 glioma tumor growth (81.6%) in vivo and resulted in significantly longer animal survival. Immunohistochemical studies demonstrated significant, eight fold greater tumor cell apoptosis in the hMSC S-TRAIL-treated group than in controls. Our study demonstrates the therapeutic efficacy of hMSC S-TRAIL cells and confirms that hMSCs can serve as a powerful cell-based delivery vehicle for the site-specific release of therapeutic proteins.</P>

Ultrasonic-assisted decoration of AuNPs on carbon nano-onions as robust electrochemical scaffold for sensing of carcinogenic hydrazine in industrial effluents

N.S.K. Gowthaman,Debananda Mohapatra,P. Arul,Wei Sea Chang 한국공업화학회 2023 Journal of Industrial and Engineering Chemistry Vol.117 No.-

This paper describes the decoration of AuNPs on carbon nano-onions (CNO) followed by its fabrication onelectrode surface for the sensitive determination of environmental pollutant hydrazine (HZ). A greenultrasonication approach was employed to decorate the AuNPs on CNOs and it follows electroless deposition. HR-TEM results reveal that spherical 10 nm-sized AuNPs were well dispersed on 30 nm-sizedCNOs. The obtained 3.7 eV spin–orbit coupling in the XPS Au4f region suggests the successful decorationof Au(0) on CNO. The Au@CNO nanostructure was then directly attached on GC electrode surface by simpleimmersion and achieved through p–p stacking interaction and the resultant electrode exhibited highelectroactive surface area and lower resistivity when compared to the CNO fabricated electrode. TheAu@CNO electrode was utilized to determine HZ in effluent samples and delivered higher electrocatalyticactivity by showing lower onset potential than the bare and CNO fabricated electrodes. The increasedelectroactive area and high electronic conductivity of Au@CNO nanostructure are attributed to theoffered lowest detection limit of 12 109 M (S/N = 3) and larger sensitivity of 485.7 lA/mM cm2. The green and environmentally benign approached Au@CNO nanostructure leads to their successfulimplementation in the determination of HZ in effluent samples.

A path-dependent fatigue crack propagation model under non-proportional modes I and III loading conditions

Mei, J.,Dong, P.,Kalnaus, S.,Jiang, Y.,Wei, Z. Pergamon Press 2017 Engineering fracture mechanics Vol.182 No.-

<P><B>Abstract</B></P> <P>It has been well established that fatigue damage process is load-path dependent under non-proportional multi-axial loading conditions. Most of studies to date have been focusing on interpretation of S-N based test data by constructing a path-dependent fatigue damage model. This paper presents a two-parameter mixed-mode fatigue crack growth model which takes into account of crack growth dependency on both load path traversed and a maximum effective stress intensity attained in a stress intensity factor plane ( e . g . , <SUB> K I </SUB> - <SUB> K III </SUB> plane). By taking advantage of a path-dependent maximum range (PDMR) cycle definition (Dong et al., 2010; Wei and Dong, 2010), the two parameters are formulated by introducing a moment of load path (MLP) based equivalent stress intensity factor range ( Δ <SUB> K NP </SUB> ) and a maximum effective stress intensity parameter <SUB> K Max </SUB> incorporating an interaction term <SUB> K I </SUB> · <SUB> K III </SUB> . To examine the effectiveness of the proposed model, two sets of crack growth rate test data are considered. The first set is obtained as a part of this study using 304 stainless steel disk specimens subjected to three combined non-proportional modes I and III loading conditions (i.e., with a phase angle of 0°, 90°, and 180°). The second set was obtained by Feng et al. (2007) using 1070 steel disk specimens subjected to similar types of non-proportional mixed-mode conditions. Once the proposed two-parameter non-proportional mixed-mode crack growth model is used, it is shown that a good correlation can be achieved for both sets of the crack growth rate test data.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Presented a two-parameter mixed-mode fatigue crack growth model. </LI> <LI> Both load path dependency and mean stress effect are considered. </LI> <LI> Validated by non-proportional mixed mode I and III crack growth tests on 304 steel. </LI> <LI> Good correlations are achieved both for test data obtained in this study and from others. </LI> </UL> </P>

Response of plasma rotation to resonant magnetic perturbations in J-TEXT tokamak

Yan, W,Chen, Z Y,Huang, D W,Hu, Q M,Shi, Y J,Ding, Y H,Cheng, Z F,Yang, Z J,Pan, X M,Lee, S G,Tong, R H,Wei, Y N,Dong, Y B IOP 2018 Plasma physics and controlled fusion Vol.60 No.3

<P>The response of plasma toroidal rotation to the external resonant magnetic perturbations (RMP) has been investigated in Joint Texas Experimental Tokamak (J-TEXT) ohmic heating plasmas. For the J-TEXT’s plasmas without the application of RMP, the core toroidal rotation is in the counter-current direction while the edge rotation is near zero or slightly in the co-current direction. Both static RMP experiments and rotating RMP experiments have been applied to investigate the plasma toroidal rotation. The core toroidal rotation decreases to lower level with static RMP. At the same time, the edge rotation can spin to more than 20 km s<SUP>−1</SUP> in co-current direction. On the other hand, the core plasma rotation can be slowed down or be accelerated with the rotating RMP. When the rotating RMP frequency is higher than mode frequency, the plasma rotation can be accelerated to the rotating RMP frequency. The plasma confinement is improved with high frequency rotating RMP. The plasma rotation is decelerated to the rotating RMP frequency when the rotating RMP frequency is lower than the mode frequency. The plasma confinement also degrades with low frequency rotating RMP.</P>

Glutathione S-transferases from the larval gut of the silkworm Bombyx mori: cDNA cloning, gene structure, expression and distribution

Gui, Z.Z.,Kim, B.Y.,Lee, K.S.,Wei, Y.D.,Guo, X.,Sohn, H.D.,Jin, B.R. INSTITUTE OF ENTOMOLOGY 2008 EUROPEAN JOURNAL OF ENTOMOLOGY Vol.105 No.4

New self-activated eulytite-type compounds of M₇Zr(PO₄)₆ (M=Ca, Sr, Ba)

Qin, L.,Wei, D.,Huang, Y.,Kim, S.I.,Yu, Y.M.,Seo, H.J. Elsevier Sequoia 2013 Journal of alloys and compounds Vol.574 No.-

Eulytite-type orthophosphates M<SUB>7</SUB>Zr(PO<SUB>4</SUB>)<SUB>6</SUB> (M=Ca, Sr, Ba) were prepared by conventional high temperature solid-state reaction. Sr<SUB>7</SUB>Zr(PO<SUB>4</SUB>)<SUB>6</SUB> and Ba<SUB>7</SUB>Zr(PO<SUB>4</SUB>)<SUB>6</SUB> crystallize in the pure eulytite-type phase with cubic space group (I4@?3d). The impurity phase β-Ca<SUB>3</SUB>(PO<SUB>4</SUB>)<SUB>2</SUB> was inevitably coexisted with the Ca<SUB>7</SUB>Zr(PO<SUB>4</SUB>)<SUB>6</SUB> phase. The luminescence properties are investigated by UV-VUV excitation and emission spectroscopy and X-ray-excited luminescence (XEL) spectroscopy. The broad excitation and emission bands are observed due to the charge transfer transition from Zr<SUP>4+</SUP> to O<SUP>2-</SUP> in M<SUB>7</SUB>Zr(PO<SUB>4</SUB>)<SUB>6</SUB> (M=Ca, Sr, Ba) eulytite. The characteristics of the phosphors including the luminescence mechanism are explained by Stokes shift, decay curves, and CIE color coordinates. The Sr<SUB>7</SUB>Zr(PO<SUB>4</SUB>)<SUB>3</SUB> and Ba<SUB>7</SUB>Zr(PO<SUB>4</SUB>)<SUB>3</SUB> phosphors exhibit unusual spectral features with the emission bands at 470 and 480nm, respectively. The weak luminescence centered at 495nm is observed in the Ca<SUB>7</SUB>Zr(PO<SUB>4</SUB>)<SUB>6</SUB> eulytite with lifetime of 4.67μs. The unusual self-activated luminescence is discussed on the base of the crystal structure of eulytite.

Unconventional superconductivity of NdFeAsO_0.82F_0.18 indicated by the low temperature dependence of the lower critical field <i>H</i>_c1

Wang, X L,Dou, S X,Ren, Zhi-An,Yi, Wei,Li, Zheng-Cai,Zhao, Zhong-Xian,Lee, Sung-IK IOP Pub 2009 Journal of physics, an Institute of Physics journa Vol.21 No.20

<P>We measured the initial <I>M</I>–<I>H</I> curves for a sample of the newly discovered superconductor NdFeAsO<SUB>0.82</SUB>Fe<SUB>0.18</SUB>, which had a critical temperature, <I>T</I><SUB>c</SUB>, of 51 K and was fabricated at the high pressure of 6 GPa. The lower critical field, <I>H</I><SUB>c1</SUB>, was extracted from the deviation point of the Meissner linearity in the <I>M</I>–<I>H</I> curves, which show linear temperature dependence in the low temperature region down to 5 K. The <I>H</I><SUB>c1</SUB>(<I>T</I>) indicates no s-wave superconductivity, but rather an unconventional superconductivity with a nodal gap structure. Furthermore, the linearity of <I>H</I><SUB>c1</SUB> at low temperature does not hold at high temperature, but shows other characteristics, indicating that this superconductor might have multi-gap features. Based on the low temperature nodal gap structure, we estimate that the maximum gap magnitude Δ<SUB>0</SUB> = (1.6 ± 0.2)  <I>k</I><SUB>B</SUB><I>T</I><SUB>c</SUB>.</P>

Parameter Design and Analysis for Aluminum Resistance Spot Welding

Cho, Yong-Joon,Li, Wei,Hu, S. Jack The Korean Welding and Joining Society 2002 대한용접·접합학회지 Vol.20 No.2

Resistance spot welding of aluminum alloys is based upon Joule heating of the components by passing a large current in a short duration. Since aluminum alloys have the potential to replace steels fur automobile body assemblies, it is important to study the process robustness of aluminum spot welding process. In order to evaluate the effects of process parameters on the weld quality, major process variables and abnormal process conditions were selected and analyzed. A newly developed two-stage, sliding-level experiment was adopted fur effective parameter design and analysis. Suitable ranges of welding current and button diameters were obtained through the experiment. The effects of the factors and their levels on the variation of acceptable welding current were considered in terms of main effects. From the results, it is concluded that any abnormal process condition decreases the suitable current range in the weld lobe curve. Pareto analysis of variance was also introduced to estimate the significant factors on the signal-to-noise (S/N) ratio. Among the six factors studied, fit-up condition is found to be the most significant factor influencing the SM ratio. Using a Pareto diagram, the optimal condition is determined and the SM ratio is significantly improved using the optimal condition.

Rejoinder: The Authors Respond to “Interpreting Ethnicity and Urbanization in Malaysia’s 2013 General Election”

Jason Wei Jian Ng,Gary John Rangel,Santha Vaithilingam,Subramaniam S. Pillay 동아시아연구원 2015 Journal of East Asian Studies Vol.15 No.2

In this article we respond to Thomas Pepinsky’s commentary on our article “2013 Malaysian Elections: Ethnic Politics or Urban Wave?” (both in this issue). We confirm that both ethnicity and urbanization play important roles in determining the incumbent ruling party’s percentage vote share in the thirteenth general election. In doing so, we address the various econometric issues raised by Pepinsky and clearly explain the advantages of our econometric methodology vis-à-vis the OLS analysis espoused by Pepinsky. Our main results indicate that Barisan National’s (BN) vote share from Bumiputera voters, regardless of urbanization levels of the parliamentary constituency, is below the 50 percent threshold. This result is surprisingly compensated by the more than 50 percent support for BN when Chinese voters are a small minority of the electorate. We also argue that Pepinsky’s statement that Malay voters are predominantly rural voters is inaccurate and provide evidence to the contrary.