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- 검색키워드
- 저자 : ( Robledo Fernando ) (검색결과 4 건)
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( Robledo Fernando ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Neurologic swallowing disorders are more frequently in rehabilitation medicine most other medical specialties. Stroke is the leading cause of neurologic dysphagia. Objective: To evaluate effectiveness of the neuroelectroestimulation (NMES) with use of VocaSTIM in the correction of swallowing disorders. Ml & ms From March 2011 until May of 2013 were 40 treatments, only 28 completed all of the treatment 28 Patients were included (18 men, 10 women) average age between 32 to 78 years. neurological sequelae other causes were esophageal bolus. We average between 8-10 sessions of 20 minutes average 2 times a week, was conducted all (VFSS): initial and control as well as a home electrodiagnosis (ED) to objectively assess degree of denervation in some cases esophageal manometry and (FEES), Methods: To establish comparisons all held you a (VFSS) initial and control as well as an electro-Diagnostics of home and its completion to objectively assess the degree of denervation and x-ray of thorax and VEDA and nasal fi beroptic endoscopic evaluation of swallowing (FEES), in the majority of cases esophageal manometry and in 2 cases Impedanciometry in 6 cases pH 24/metry. Results: Response was assessed according to degree of clinical and scale as well as the corresponding (ED)dysphagia.. Patient satisfaction /Values of ED (fi nals) /Score of speech /grade of dysphagia evaluation It was noted a degree of positive response (degree of satisfaction) in more of the 80 % patients as well as a superior response to the 90 % (ED), speech evaluation is considered good to very good in more of the 80 % of the patients. High degree of response in diseases with neurological lesions (was observed in diseases neurodegenerative (ALS, Parkinson,) the response was considered poor (regular/good) Conclusions: VocaSTIM® can produce a different degree of satisfaction functional response in the majority of patients with dysphagia.
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( Robledo Fernando ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Objective: To evaluate the effectiveness and response Gastric balloon ( Lexbal ) in the treatment of mild to moderate obesity Observational and retrospective : Experimental design Methods: Intervention: We conducted in two clinics (Our Lady of Pilar and Clinica B & S ) an observational, retrospective study. We have compiled the results of 10 follow intragastric balloons (Balon Lexbal ) in obese patients with mild to moderate type I- II (BMI between 28 and 34.9 kg/m2 ) placed in 2012 and 2013 losses have been achieved. over 70 % of excess weight. Furthermore, it has been observed satisfaction of our patients Measurements: Descriptive observational study in which the sample is made up of the 10 patients treated with balloon LEXBAL in our midst. The variables studied were age, sex, weight, BMI, percentage of weight lost, fi ll volume, tolerance, satisfaction and dietary monitoring by patients Results: Over 80 % degree of patient satisfaction, 70 % decrease in weight above the average ( over 12 kilos ) better response in those presenting adherence to nutritional treatment and no differences were observed in the volume of fi lling the balloon. Conclusions: Treatment with intragastric balloon, along with a nutritional monitoring allows us to re-educate the patient, and change their eating habits. · Just for gradual diet, and to adapt each phase as tolerated by the patient, helps us to improve dietary behavior and facilitates greater weight loss The intragastric balloon is a safe, well tolerated, with few adverse effects and relatively simple in the hands accustomed to endoscopic practice. We believe it can be considered an effective adjunctive therapy in selected cases of mild / moderate obesity (type I-II). Keywords: Balon intragastric nutritional monitoring, treatment safe, well tolerated, with few adverse effects.
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( Daniel Fernando Robledo ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: The intragastric balloon can be used for weight reduction for mild to moderate obesity, weight loss or as a pre- or preoperative choice for morbid obesity -super- obesity. The intragastric balloon is a temporary treatment for obese patients. Methods: Prospective, double-blind Obesity in 30 patients with type I and type 2 obesity: 23 women and 7 men, 43.9 ± 10, 120.3 ± 17 kg, and body mass index (BMI) of 44, 2 ± 5 kg/m2, 10 placing gastric balloons (Lexbal®). 20 -BIB intragastric balloons Allergan ®). fi lled with 700 ml of saline. Both balls were placed with conscious sedation and general anesthesia withdrawn at 6 months. Intravenous and oral medications are given to control symptoms for 48-72 h. Complications, symptoms, weight and quality of life evaluated by Life Index (GIQLI) every 30/45 days were recorded. Results: At 6 months, the balloons were removed endoscopically, with a mean weight loss (12.8 ± 8 vs 14.1 ± 8 kg), BMI loss (4.6 ± 3 vs 5.5 ± 3 kg/m2) showed no signifi - cant differences between groups. The withdrawal of the balloons 1 balloon Lexbal not found in the stomach, and three patients required removal of the BIB balloon endoscopy. Tolerance was good in both groups Conclusions: Both intragastric balloons achieved signifi cant weight loss with good tolerance in obese patients and no serious complications were observed correlated with any of the balloons.
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( Francisco J. Pérez-de Los Santos ),( Luis Fernando García-ortega ),( Karina Robledo-márquez ),( Jesús Guzmán-moreno ),( Lina Riego-ruiz ) 한국미생물생명공학회(구 한국산업미생물학회) 2021 Journal of microbiology and biotechnology Vol.31 No.5
After Candida albicans, Candida glabrata is one of the most common fungal species associated with candidemia in nosocomial infections. Rapid acquisition of nutrients from the host is important for the survival of pathogens which possess the metabolic flexibility to assimilate different carbon and nitrogen compounds. In Saccharomyces cerevisiae, nitrogen assimilation is controlled through a mechanism known as Nitrogen Catabolite Repression (NCR). NCR is coordinated by the action of four GATA factors; two positive regulators, Gat1 and Gln3, and two negative regulators, Gzf3 and Dal80. A mechanism in C. glabrata similar to NCR in S. cerevisiae has not been broadly studied. We previously showed that in C. glabrata, Gln3, and not Gat1, has a major role in nitrogen assimilation as opposed to what has been observed in S. cerevisiae in which both factors regulate NCR-sensitive genes. Here, we expand the knowledge about the role of Gln3 from C. glabrata through the transcriptional analysis of BG14 and gln3Δ strains. Approximately, 53.5% of the detected genes were differentially expressed (DEG). From these DEG, amino acid metabolism and ABC transporters were two of the most enriched KEGG categories in our analysis (Up-DEG and Down-DEG, respectively). Furthermore, a positive role of Gln3 in AAA assimilation was described, as was its role in the transcriptional regulation of ARO8. Finally, an unexpected negative role of Gln3 in the gene regulation of ABC transporters CDR1 and CDR2 and its associated transcriptional regulator PDR1 was found. This observation was confirmed by a decreased susceptibility of the gln3Δ strain to fluconazole.
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