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Dielectric Response of Human Melanoma Cells on the Surface of Polymeric Chemoattractants
Richard B. Beard,김현주,로현,문기욱,전흥재 한국조직공학과 재생의학회 2012 조직공학과 재생의학 Vol.9 No.1
The influences of dielectric properties on the malignant cell adhesion and migration have been investigated. The Wistar Melanomas, primary (WM793) and metastatic (WM1205), respectively, were chosen as the model cell lines because of their pleomorphic and invasive characteristics, and the dielectric relaxation frequencies of the cells were determined using the impedance spectroscopy. Both WM793 and WM1205 showed the enhanced adhesion and the interesting changes in their morphology under the dielectric stimulations. However, it was found that the changed conditions of cell adhesion due to dielectric relaxation did not influence the migrational behavior of the cells.
Migrational Behavior of Human Melanoma towards Polymeric Chemoattractants
( Kyu Nam Park ),( Han Joon Kim ),( Jung Hee Wee ),( Who Kyong Lee ),( Heung Jae Chun ),( Ju Woong Jang ),( Richard B Beard ) 한국조직공학·재생의학회 2008 조직공학과 재생의학 Vol.5 No.4
In order to understand the molecular mechanisms of chemotaxes through reactive oxygen species(ROS), the polymeric chemoattractants with free radical generating compounds were prepared, and the migrational behavior of melanoma cells towards the samples was investigated using a Boyden chamber assay. The samples with quinoid compounds had an enhanced melanoma cells migration than control. The migrational abilities of cells were further increased when the free radicals on the surface of samples were activated with blood plasma.
Human Melanoma Cells Adhesion on the Surface of Polymeric Chemoattractants
( Heung Jae Chun ),( Ju Woong Jang ),( Han Joon Kim ),( Kyu Nam Park ),( Jung Hee Wee ),( Who Kyong Lee ),( Anthony Addison ),( Richard B. Beard ) 한국조직공학·재생의학회 2008 조직공학과 재생의학 Vol.5 No.4
Two dimensional(2-D) polymeric matrices with free radical generating quinoid compounds, hydroquinone- grafted-polypropylene(HQ-g-PP) and vitamin-K1-grafted-polypropylene(VK1-g-PP), were prepared by a liquid phase photo-grafting technique, and the adhesion of primary(WM 793) and metastatic(WM 1205) human melanoma cells to prepared surfaces was investigated. Grafting of polar groups in VK1and HQ increased surface tension of PP matrices from 27 dyne/cm to 39 dyne/cm, resulting in decreased protein adsorption. In addition, electron paramagnetic resonance(EPR) spectra showed that the matrices generated free radicals at the interface when in contact with serum. Both WM 793 and WM 1205 cells showed an enhanced adhesion to the prepared samples compared to the control PP. The adhesion of metastatic melanoma cells onto the polymeric matrices was more pronounced than that of primary melanoma cells. VK1-g-PP with twice as many free radical generating groups in a unit graft yield as HQ-g-PP had a greater cell adhesion. The number of cells adhered to the surface of the polymeric chemoattractants increases with increase in the content of free radicals at the interface.