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Ravi P. Agarwal,Ram U. Verma 영남수학회 2011 East Asian mathematical journal Vol.27 No.5
Abstract. Based on the A-maximal (m)-relaxed monotonicity frame-works, the approximation solvability of a general class of variational in-clusion problems using the relaxed proximal point algorithm is explored,while generalizing most of the investigations, especially of Xu (2002) on strong convergence of modied version of the relaxed proximal point al-gorithm, Eckstein and Bertsekas (1992) on weak convergence using the relaxed proximal point algorithm to the context of the Douglas-Rachford splitting method, and Rockafellar (1976) on weak as well as strong con-vergence results on proximal point algorithms in real Hilbert space set-tings. Furthermore, the main result has been applied to the context of the H-maximal monotonicity frameworks for solving a general class of vari-ational inclusion problems. It seems the obtained results can be used to generalize the Yosida approximation that, in turn, can be applied to rst-order evolution inclusions, and can also be applied to Douglas-Rachford splitting methods for nding the zero of the sum of two A-maximal (m)-relaxed monotone mappings.
Agarwal, Ravi P.,Verma, Ram U. The Youngnam Mathematical Society Korea 2011 East Asian mathematical journal Vol.27 No.5
Based on the A-maximal(m)-relaxed monotonicity frameworks, the approximation solvability of a general class of variational inclusion problems using the relaxed proximal point algorithm is explored, while generalizing most of the investigations, especially of Xu (2002) on strong convergence of modified version of the relaxed proximal point algorithm, Eckstein and Bertsekas (1992) on weak convergence using the relaxed proximal point algorithm to the context of the Douglas-Rachford splitting method, and Rockafellar (1976) on weak as well as strong convergence results on proximal point algorithms in real Hilbert space settings. Furthermore, the main result has been applied to the context of the H-maximal monotonicity frameworks for solving a general class of variational inclusion problems. It seems the obtained results can be used to generalize the Yosida approximation that, in turn, can be applied to first- order evolution inclusions, and can also be applied to Douglas-Rachford splitting methods for finding the zero of the sum of two A-maximal (m)-relaxed monotone mappings.
Google Search Trends Predicting Disease Outbreaks: An Analysis from India
Madhur Verma,Kamal Kishore,Mukesh Kumar,Aparajita Ravi Sondh,Gaurav Aggarwal,Soundappan Kathirvel 대한의료정보학회 2018 Healthcare Informatics Research Vol.24 No.4
Objectives: Prompt detection is a cornerstone in the control and prevention of infectious diseases. The Integrated Disease Surveillance Project of India identifies outbreaks, but it does not exactly predict outbreaks. This study was conducted to assess temporal correlation between Google Trends and Integrated Disease Surveillance Programme (IDSP) data and to determine the feasibility of using Google Trends for the prediction of outbreaks or epidemics. Methods: The Google search queries related to malaria, dengue fever, chikungunya, and enteric fever for Chandigarh union territory and Haryana state of India in 2016 were extracted and compared with presumptive form data of the IDSP. Spearman correlation and scatter plots were used to depict the statistical relationship between the two datasets. Time trend plots were constructed to assess the correlation between Google search trends and disease notification under the IDSP. Results: Temporal correlation was observed between the IDSP reporting and Google search trends. Time series analysis of the Google Trends showed strong correlation with the IDSP data with a lag of –2 to –3 weeks for chikungunya and dengue fever in Chandigarh (r > 0.80) and Haryana (r > 0.70). Malaria and enteric fever showed a lag period of –2 to –3 weeks with moderate correlation. Conclusions: Similar results were obtained when applying the results of previous studies to specific diseases, and it is considered that many other diseases should be studied at the national and sub-national levels.
Properties of concrete incorporating sand and cement with waste marble powder
Ashish, Deepankar K.,Verma, Surender K.,Kumar, Ravi,Sharma, Nitisha Techno-Press 2016 Advances in concrete construction Vol.4 No.2
Marble is a metamorphic rock used widely in construction which increases amount of marble powder obtained from it. Marble powder is a waste product obtained from marble during its processing. Marble waste is high in calcium oxide content which is cementing property but it creates many environmental hazards too if left in environment or in water. In this research, partial replacement of cement and sand by waste marble powder (WMP) has been investigated. Seven concrete mixtures were prepared for this investigation by partially replacing cement, sand with WMP at proportions of 0%, 10% and 15% by weight separately and in combined form. To determine compressive strength, flexural strength and split tensile strength of concrete made with waste marble powder, the samples at the curing ages of 7, 28 and 90 days was recorded. Different tests of durability were applied on samples like ultrasonic pulse wave test, absorption and sorptivity. For further investigation all the results were compared and noticed that WMP has shown good results and enhancing mechanical properties of concrete mix on partially replacing with sand and cement in set proportions. Moreover, it will solve the problem of environmental health hazard.
Locus-Specific Reversible DNA Methylation Regulates Transient IL-10 Expression in Th1 Cells
Hwang, Won,Lee, Choong-Gu,Lee, Changhon,Verma, Ravi,Rudra, Dipayan,Park, Zee Yong,Im, Sin-Hyeog American Association of Immunologists 2018 Journal of Immunology Vol. No.
<P>IL-10 is a pleiotropic cytokine with multifaceted functions in establishing immune homeostasis. Although expressed by Th1 and Th2 cells, conventional Th1 cells produce marginal levels of IL-10 compared with their Th2 counterparts. In this study, we investigated the epigenetic mechanisms of <I>Il-10</I> gene expression in Th1 cells. Bioinformatics EMBOSS CpG plot analysis and bisulfite pyrosequencing revealed three CpG DNA methylation sites in the <I>Il-10</I> gene locus. Progressive DNA methylation at all of the CpG regions of interest (ROIs) established a repressive program of <I>Il-10</I> gene expression in Th1 cells. Interestingly, Th1 cells treated with IL-12 and IL-27 cytokines, thereby mimicking a chronic inflammatory condition in vivo, displayed a significant increase in IL-10 production that was accompanied by selective DNA demethylation at ROI 3 located in intron 3. IL-10–producing T cells isolated from lymphocytic choriomeningitis virus–infected mice also showed enhanced DNA demethylation at ROI 3. Binding of STAT1 and STAT3 to demethylated ROI 3 enhanced IL-10 expression in an IL-12/IL-27–dependent manner. Accordingly, CD4<SUP>+</SUP> T cells isolated from STAT1- or STAT3-knockout mice were significantly defective in IL-10 production. Our data suggest that, although stably maintained DNA methylation at the promoter may repress IL-10 expression in Th1 cells, locus-specific reversible DNA demethylation may serve as a threshold platform to control transient <I>Il-10</I> gene expression.</P>
Kumar, Rajeev,Ghosh, Sankar Kumar,Verma, Akalesh Kumar,Talukdar, Anuradha,Deka, Monoj Kumar,Wagh, Mira,Bahar, H.M. Iqbal,Tapkire, Ritesh,Chakraborty, Kali Pankaj,Kannan, R. Ravi Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.16
Background: Esophageal squamous cell carcinoma (ESCC) is a common cancer in the north east of India. The present study concerned the prevalence of human papilloma virus (HPV) in the ESCC in north eastern India and its impact on response to chemotherapy. Materials and Methods: p16 expression, a surrogate marker for HPV infection was assessed in 101 pre-treatment biopsies of locally advanced ESCC, reported from a comprehensive cancer centre in north east India, using immunohistochemistry. All patients received neo-adjuvant chemotherapy. Response was assessed clinically and histopathologically with attention to p16 expression. Results: p16 was expressed in 22% of ESCC (22 out of 101) and was more prevalent in patients who were more than 45 years of age (P=0.048). p16 positive tumors appeared more commonly in the upper 2/3 of the thoracic esophagus (18 in 22). Nine of the 22 (41%) p16 positive tumors achieved pathologic complete response following neo-adjuvant chemotherapy (P=0.008). There was a trend towards reduced mortality in this group (P=0.048). Some 9 of the 20 (45%) patients who achieved pathologic complete response were p16 positive. Conclusions: Expression of p16 in ESCC correlates with higher rate of pathologic complete remission in patients undergoing neo adjuvant chemotherapy and could be a predictive marker for response assessment.