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Synthesis and In Vitro Cytotoxicity of Cis-[Pt(NH3)(NH2OH)Cl2]
Qing-Song Ye,Xi-Zhu Chen,Yao Yu,Qiao-Wen Chang,Shu-Qian Hou,Wei-Ping Liu 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.6
A novel mixed NH3/NH2OH platinum(II) complex cis-[Pt(NH3)(NH2OH)Cl2] was synthesized and characterized by elemental analysis, FAB-MS, FT-IR and 1H NMR spectroscopy. This complex was determined to have a good water-solubility and satisfactory stability. The pertinent complex was evaluated for its in vitro cytotoxicity against 3AO, HCT-116, LNcap, A549/ATCC and SGC-7901 human carcinoma cell lines. It shows appreciable cytotoxic activity that is comparable with cisplatin and is much more active than carboplatin.