Promising Iron Oxide-based Magnetic Nanoparticles in Biomedical Engineering

Phuong Ha-Lien Tran,Thao Truong-Dinh Tran,Toi Van Vo,이범진 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.12

For the past few decades biomedical engineering has imprinted its significant impact on the map of science through its wide applications on many other fields. An important example obviously proving this fact is the versatile application of magnetic nanoparticles in theranostics. Due to preferable properties such as biocompatibility, non-toxicity compared to other metal derivations, iron oxide-based magnetic nanoparticles was chosen to be addressed in this review. Aim of this review is to give the readers a whole working window of these magnetic nanoparticles in the current context of science. Thus, preparation of magnetic iron oxide nanoparticles with the so-far techniques, methods of characterizing the nanoparticles as well as their most recent biomedical applications will be stated.

Roles of MgO Release from Polyethylene Glycol 6000-based Solid Dispersions on Microenvironmental pH, Enhanced Dissolution and Reduced Gastrointestinal Damage of Telmisartan

Phuong Ha Lien Tran,이범진,Thao Truong-Dinh Tran,Seung Aeon Lee,Vo Hong Nho,Sang-Cheol Chi 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.5

The roles of magnesium oxide (MgO) release from solid dispersions (SDs) in simulated gastric fluid (SGF), simulated intestinal fluid (SIF) and water were investigated to elucidate the enhanced dissolution and reduced intestinal damages of telmisartan as a model drug. The polyethylene glycol 6000 (PEG 6000) was used to prepare the SDs. Three SDs were prepared: SD1(PEG, MgO, TEL), SD2 (PEG 6000, TEL), SD3 (MgO, TEL). The physical mixture (PM) consisting of SD2 and MgO was also prepared. A binary SD without MgO (SD2) was also prepared for comparison in microenvironmental pH (pH_M) modulation. The faster MgO released, the less control of pH_M and the less enhanced dissolution of TEL were in consequences. SD3 increased dissolution in SIF and water (about 67%). Interestingly, ternary SD1 showed almost complete dissolution in all three media but dissolution of PM was the lowest due to the fast release of MgO and poor modulation of pHM. MgO did not change the drug crystallinity but did have a strong molecular interaction with the drug. Additionally, the SD3-bearing tablet quickly increased pHM but then gradually decreased due to faster release of MgO while the SD1-bearing tablet gradually increased pH_M at all fractional dimensions of the tablet by the MgO slowly released. The pH_M of PM-bearing tablets was not varied as a function of time. Thus, the MgObearing SD1 also minimized gastrointestinal tissue damage caused by the model drug.

Biodistribution and <i>in vivo</i> performance of fattigation-platform theranostic nanoparticles

Tran, Thao Truong-Dinh,Tran, Phuong Ha-Lien,Amin, Hardik H.,Lee, Beom-Jin Elsevier 2017 Materials science & engineering. C, Materials for Vol.79 No.-

<P><B>Abstract</B></P> <P>This study was aimed at characterizing superparamagnetic nanoparticles surface-functionalized with gelatin-oleic acid (GOAS-MNPs) and loaded with paclitaxel by assessing the pharmacokinetics and biodistribution of paclitaxel in tissues and the <I>in vivo</I> efficacy of antitumor activity after the administration of the drug. Initially, instrumental analysis was performed to examine the particle size distribution, surface charge, and morphology of the paclitaxel-loaded GOAS-MNPs. Furthermore, we evaluated their magnetic properties and performed T2-weighted magnetic resonance imaging (MRI) on cells. We intravenously administered Taxol® and paclitaxel-loaded GOAS-MNPs and compared the pharmacokinetics, biodistribution, and antitumor efficacies of the two formulations. Determination of the pharmacokinetics and the biodistribution of paclitaxel-loaded NPs showed that this formulation increased the systemic circulation time of paclitaxel and regulated its transport to tissues. The <I>in vivo</I> antitumor efficacy of the paclitaxel-loaded NPs was better than that of Taxol® at the same dose. Furthermore, the paclitaxel-loaded GOAS-MNPs were found to be effective as contrast agents for enhanced MRI in cancer cells. Thus, GOAS-MNPs could be an effective diagnostic system for cancer and for the delivery of paclitaxel with better therapeutic effects and a significant reduction in toxicity.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Improving therapeutic efficacy and lower toxicity </LI> <LI> A significant inhibition of tumor growth </LI> <LI> Could be used as MRI contrast agents </LI> </UL> </P>

Fattigation-platform theranostic nanoparticles for cancer therapy

Tran, Thao Truong-Dinh,Tran, Phuong Ha-Lien,Yoon, Tae-Jong,Lee, Beom-Jin Elsevier 2017 Materials science & engineering. C, Materials for Vol.75 No.-

<P>A new conceptual nanoparticle consisting of a silica-coated iron oxide magnetic core and a fattigation-based biocompatible shell with oleic acid and hydrophilic protein (gelatin). The prepared particle can be a useful theranostics platform material for diagnostic imaging and as a drug delivery system. Oleic acid and gelatin were conjugated on the silica-coated magnetic nanoparticle surface to provide three primary functionalities: 1) enhancing biocompatibility and solubility in aqueous solution and providing the ability to incorporate hydrophobic chemical drugs into the shell for delivery, 2) improving treatment-response magnetic monitoring as a diagnostic agent with low nanotoxicity, and 3) increasing anticancer efficacy owing to the controlled release of the incorporated drug in cells and in an animal model. We prepared magnetic-silica nanoparticles with super paramagnetic properties, which are utilized as a T-2-weighted magnetic resonance imaging agent. After formation of an oleic acid-gelatin shell, the prepared materials exhibited high loading capacity for a hydrophobic anticancer drug (paclitaxel). Our particle platform system exhibited higher therapeutic efficacy and lower toxicological effects in vitro and in an in vivo cancer model than a clinically available chemo-drug (Taxol (R)). Our findings strongly suggest that this nanoparticle system can serve as a platform for cancer therapy by the incorporation of chemical drugs. (C) 2017 Elsevier B.V. All rights reserved.</P>

Preliminary Imaging Analysis for Enhanced Intestinal Uptake of Non-soluble Polystyrene Microspheres in the Presence of Oleic Acid using Rat Intestine

Tran, Huyen Thi Thanh,Tran, Phuong Ha Lien,Tran, Thao Truong-Dinh,Lee, Kyung-Ho,Lee, Beom-Jin The Korean Society of Pharmaceutical Sciences and 2009 Journal of Pharmaceutical Investigation Vol.39 No.3

In vitro intestinal uptake of non-soluble polystyrene microspheres (NPMS) was visualized with and without oleic acid using a fluorescence microscopy. Fluorescent polystyrene latex microspheres with 1${\mu}$m larger size were used as models for nonspecifically absorbed nonbiodegradable particulates. The NPMS could not penetrate the enterocytes but a few NPMS could be penetrated via Peyer's patches. When the oleic acid was mixed with NPMS, the transporting efficiency of NPMS through enterocytes as well as Peyer's patches was significantly enhanced. The modification of the intestinal membrane permeability and surface feature of the NPMS in the presence of oleic acid might be a clue to the transport of NSPM although the detailed mechanism is still under investigation.

Customer Satisfaction with Less than Container Load Cargo Services in HoChiMinh City, Vietnam

GIAO, Ha Nam Khanh,THY, Nguyen Thi Anh,VUONG, Bui Nhat,TU, Tran Ngoc,VINH, Pham Quang,LIEN, Le Thi Phuong Korea Distribution Science Association 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.8

This research has four specific objectives: (1) identifying factors that affect customer satisfaction with less than container load (LCL) cargo services of logistics companies in HoChiMinh City (HCMC), (2) measuring the level of impact of the factors, (3) testing the difference in satisfaction among groups of customers with different characteristics in terms of type of business and time of using LCL cargo services, and (4) proposing some management implications to improve the quality of LCL cargo services. Researchers interviewed 210 customers who enjoyed the LCL cargo service in HCMC for at least the last six months, using the convenient sampling method. SPSS 20 was used to analyze the reliability of the scale through the Cronbach's alpha coefficient, then exploratory factor analysis and multiple linear regression analysis were used. The results identified the six factors that influence positively customer satisfaction of LCL cargo services of logistics companies in HCMC, by decreasing importance: service process, image, resource, price, management, and outcomes. The results show that there is no difference in customer satisfaction with LCL cargo services by types of business as well as time of using services. The research suggests some implications for the management of logistics companies in HCMC to enhance customer satisfaction.

Investigation of Degradation Mechanism of Rabeprazole with Solid State Pharmaceutical Excipients

Ren, Shan,Tran, Thao Truong-Dinh,Tran, Phuong Ha-Lien,Rhee, Yun-Seok,Lee, Beom-Jin The Korean Society of Pharmaceutical Sciences and 2010 Journal of Pharmaceutical Investigation Vol.40 No.6

Rabeprazole sodium (RPN) is known to be very unstable at acidic condition or some acidic pharmaceutical excipients such as acrylic acid polymer (carbomer 934) with carboxylic acids. Thus, degradation mechanism of binary blends of rabeprazole with pharmaceutical excipients in a solid state without using solvents at three different ratios (3:1, 1:1 and 1:3) was investigated using Fourier transform infrad (FTIR) spectroscopy. Alkalizer (MgO), neutral hydroxypropymethylcellulose (HPMC 4000) were also tested for comparison. The binary blends were stored under accelerated conditions ($40^{\circ}C$/75% relative humidity) for two weeks. The concentration of thioether rabeprazole from the binary blends with acidic carbomer 934 increased as the rabeprazole concentration decreased. In addition, the degradation half-life of rabeprazole as well as the relative peak area ratios obtained from FTIR spectra of S=O stretching at $1094.1\;cm^{-1}$ decreased consistently as the fraction of carbomer 934 increased due to its sensitivity between the basic benzimidazole nitrogen and carboxylic acid group of carbomer 934. The physical appearance also turned into strong brown color in the presence of carbomer 934. In contrast, there were no significant changes in the degradation kinetics of rabeprazole with MgO and HPMC 4000 in a solid state. This present study demonstrated that the solid-state compatibility test with the aid of HPLC chromatographic and FTIR spectral analyses could offer a valuable methodology to select suitable pharmaceutical excipients and to elucidate the degradation mechanism of RPN for drug formulations at the early formulation stages.

Effects of Solvents and Crystallization Conditions on the Polymorphic Behaviors and Dissolution Rates of Valsartan

Thao Truong-Dinh Tran,이범진,Phuong Ha-Lien Tran,박준범 대한약학회 2012 Archives of Pharmacal Research Vol.35 No.7

For the quality evaluation of raw materials, the influence of various types of solvents on the polymorphic crystallization behaviors and dissolution rates of two sources of valsartan (VAL) from China and India was investigated. Samples were prepared by recrystallization from water or organic solvents, such as acetonitrile, acetone and ethanol, using methods with and without heating. Recrystallization behaviors were characterized by differential scanning calorimetry (DSC) and powder X-ray diffraction (PXRD). Scanning electron microscopy (SEM) was also used to observe the morphology of samples. The dissolution rate of recrystallized samples in water was evaluated and compared to the original VAL sample. There were significant differences in morphology, crystal structure and dissolution rate among the samples recrystallized using organic solvents. VAL was transformed into another polymorphic form by the solvents and recrystallization conditions. These physical properties of VAL also differed between the two sources of VAL. Thus, the physicochemical differences of raw materials should be carefully considered in early dosage formulation approaches.

Preliminary Imaging Analysis for Enhanced Intestinal Uptake of Non-soluble Polystyrene Microspheres in the Presence of Oleic Acid using Rat Intestine

Huyen Thi Thanh Tran,Phuong Ha Lien Tran,Thao Truong Dinh Tran,Kyung Ho Lee,Beom Jin Lee 韓國藥劑學會 2009 Journal of Pharmaceutical Investigation Vol.39 No.3

Zein-based solid dispersion for potential application in targeted delivery

Minh Ngoc‑Uyen Nguyen,Toi Van Vo,Phuong Ha‑Lien Tran,Thao Truong‑Dinh Tran 한국약제학회 2017 Journal of Pharmaceutical Investigation Vol.47 No.4

The study aims to design and evaluate the ability of zein in solid dispersion (SD) system to enhance drug dissolution rate for a further application of colonic delivery of poorly water-soluble drug. The SD samples were prepared by solvent method and the investigation of drug release was performed at pH 7.4. The wettability, molecular interactions and drug’s crystal behaviours of SDs were studied by contact angle measurement, Fourier transform infrared spectroscopy (FTIR) and powder X-ray diffraction (PXRD), respectively. Zein-based SDs showed its potential in enhancing the rate of drug release. The PXRD results pointed out a rearrangement of drug’s crystalline structure in some SD samples through the appearance of new peaks on PXRD diffractogram, while a formation of a hydrogen bond between prednisolone (PRL) and zein was also confirmed by FTIR spectra. It was evident that a strong relationship between the amount of zein and the dissolution rate of PRL in SD system attributed to zein hydrophobicity, recrystallization and molecular interaction which were factors inducing the enhanced drug release rate. In conclusion, zein is a potential carrier for controlled release SD systems, especially further application for poorly water-soluble drugs in colonic delivery like PRL due to the resistance of zein at low pH environment.