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( Marta Adonis ),( Carolina Tamayo ),( Ulises Urzua ),( Jose Diaz ),( Marco Chahuan ),( Rosana Miranda ),( Alcides Zambrano ),( Monica Campos ),( Pedro Marin ),( Hugo Benitez ),( Lionel Gil ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Lung cancer (LC) is the leading cause of cancer-related mortality worldwide and in Antofagasta region, and the second cause of cancer mortality in Chile. The high incidence and mortality of LC has been associated to diagnosis in advances stages. Free circulating DNA (DNAfc) in serum or plasma has been described as a promising cancer marker. A high concentration as well as genetic and epigenetic alterations of DNAfc has been associated to various types of cancer. This work has studied the levels of DNAfc in a population with high risk of LC and also to characterize its Copy Number Alterations (CNAs). Methods: Volunteers enrolled in an early detection project (CeTeCancer), were classifi ed as healthy control (C), Pre Neoplastic Lesions (PNL) and Lung Cancer (LC), according to results of Quantitative Automatic Cytology (QAC) in sputum specimen, DR70 tumour marker Autofi uorescence Bronchoscopy (AFB) and Histophatology assay. The amplifi ed ADNfc was co-hybridized against genomic DNA from total blood, using microarray-HGC. Results: LC volunteers showed higher DNAfc levels than C and PNL volunteers. Four recurrent and signifi cant deletions were detected in 2p, 7q, 11q and 17p in LC volunteers. Non signifi cant alterations were detected in PLN. Genes located in segments with CNAs were associated to immune response, xenobiotic metabolism, oxidative phosphorilation, cell proliferation and cell cycle regulation, apoptosis, differentiation and cellular adhesion and migration, all functions relevant to neoplastic progression. Conclusions: fcDNA showed higher levels in LC patients than control volunteers and patients with Pre Neoplastic Lesions (PNL). Many genomic loci identifi ed as signifi - cantly have been associated with the LC and might be consider candidates as genomic markers. This research was supported by INNOVA CORFO.
pep27 and LytA in Vancomycin-Tolerant Pneumococci
( Alma Olivares ),( Jose Olivares Trejo ),( Jose Arellano Galindo ),( Gerardo Zuniga ),( Gerardo Escalona ),( Juan Carlos Vigueras ),( Paula Marin ),( Juan Xicohtencatl ),( Pedro Valencia ),( Norma Ve 한국미생물 · 생명공학회 2011 Journal of microbiology and biotechnology Vol.21 No.12
Vancomycin therapy failure due to the emergence of tolerance in pneumococci is increasing. The molecular mechanism of tolerance is not clear, but lytA and pep27 are known to be involved. Our aim was to evaluate the expression of both genes in vancomycin-tolerant Streptococcus pneumoniae (VTSP) strains. Eleven VTSP strains from a total of 309 clinical isolates of S. pneumoniae from 1997 to 2006 were classified according to the criteria of Liu and Tomasz. All VTSP strains were evaluated for susceptibility according to CLSI criteria, serotype by the Quellung test, and clonality by PFGE. The expressions of lytA and pep27 were analyzed in different growth phases by RT-PCR with and without vancomycin. Eighty-two percent of VTSP strains showed resistance to penicillin, and 100% were sensitive to vancomycin and cefotaxime. The most frequent serotypes of VTSP strains were 23F (4/11) and 6B (3/11). Clonal relationship was observed in only two strains. No significant changes were observed in pep27 expression in the three phases of growth in VTSP strains with and without vancomycin. Interestingly, pep27 expression in the stationary phase in the non-tolerant reference strain R6 was significantly higher. However, no significant differences in lytA expression were observed between VTSP and R6 strains during the phases of growth analyzed. The absence of changes in pep27 expression in VTSP strains in the stationary phase may be related to their ability to tolerate high antibiotic concentrations, and thus, they survive and remain in the host under the antibiotic selective pressure reflected in therapeutic failure.
Elo a Moreira-Marconi,Carla F. Dionello,Danielle S. Morel,Danubia C. S a-Caputo,Cintia R. Souza-Gonçalves,Laisa L. Paineiras-Domingos,Eliane O. Guedes-Aguiar,Pedro J. Marin,Borja del Pozo Cruz,Mario B 대한골다공증학회 2016 Osteoporosis and Sarcopenia Vol.2 No.4
Objective: The aim of this study was to review the literature about the relevance of the whole body vibration (WBV) in decreasing the number of fractures in osteoporotic women. Methods: Searches were performed by three independent researchers through the PubMed and PEDro databases. Results: Only 0.1% of the publications with “Fracture and osteoporosis” have a relation with WBVexercise. The achievements have revealed a positive effect of this exercise in patients with risk factors for fractures like osteoporosis. Protocols were performed two to three times a week, from 6 up to 18 months, and with 12.6 up to 40 Hz as frequencies. Different tools were used to evaluate the effects of the WBV exercise in conditions that could cause fractures in postmenopausal women. Conclusions: Although the paucity of research regarding direct effects of WBV in decreasing fractures, WBV could be a feasible and effective way to modify well-recognized risk factors for falls and fractures, improvements in some aspects of neuromuscular function and balance. More studies have to be performed establish protocols with well controlled parameters.