Investingation of the shape of the dots in laser irradiated crystal and PMMA using optical coherence tomography

Sohee Park,Youngseop Kim,Yongjin Shin 한국레이저가공학회 2005 Laser Solutions Vol.8 No.2

CT Evaluation for Clinical Lung Cancer Staging: Do Multiplanar Measurements Better Reflect Pathologic T-Stage than Axial Measurements?

Sohee Park,Sang Min Lee,최주애,이준구,이상민,도경현,Joon Beom Seo 대한영상의학회 2019 Korean Journal of Radiology Vol.20 No.7

Objective: To retrospectively investigate whether tumor size assessment on multiplanar reconstruction (MPR) CT images better reflects pathologic T-stage than evaluation on axial images and evaluate the additional value of measurement in threedimensional (3D) space. Materials and Methods: From 1661 patients who had undergone surgical resection for primary lung cancer between June 2013 and November 2016, 210 patients (145 men; mean age, 64.4 years) were randomly selected and 30 were assigned to each pathologic T-stage. Two readers independently measured the maximal lesion diameters on MPR CT. The longest diameters on 3D were obtained using volume segmentation. T-stages determined on CT images were compared with pathologic T-stages (overall and subgroup—Group 1, T1a/b; Group 2, T1c or higher), with differences in accuracy evaluated using McNemar’s test. Agreement between readers was evaluated with intraclass correlation coefficients (ICC). Results: The diagnostic accuracy of MPR measurements for determining T-stage was significantly higher than that of axial measurement alone for both reader 1 (74.3% [156/210] vs. 63.8% [134/210]; p = 0.001) and reader 2 (68.1% [143/210] vs. 61.9% [130/210]; p = 0.049). In the subgroup analysis, diagnostic accuracy with MPR diameter was significantly higher than that with axial diameter in only Group 2 (p < 0.05). Inter-reader agreements for the ICCs on axial and MPR measurements were 0.98 and 0.98. The longest diameter on 3D images showed a significantly lower performance than MPR, with an accuracy of 54.8% (115/210) (p < 0.05). Conclusion: Size measurement on MPR CT better reflected the pathological T-stage, specifically for T1c or higher stage lung cancer. Measurements in a 3D plane showed no added value.

MALDI-TOF Mass Spectrometry Based on Parylene-Matrix Chip for the Analysis of Lysophosphatidylcholine in Sepsis Patient Sera

Park, Jong-Min,Noh, Joo-Yoon,Kim, Moon-Ju,Yun, Tae Gyeong,Lee, Sang-Guk,Chung, Kyung Soo,Lee, Eun Hye,Shin, Mi Hwa,Ku, Nam Su,Yoon, Sohee,Kang, Min-Jung,Park, Moo Suk,Pyun, Jae-Chul American Chemical Society 2019 ANALYTICAL CHEMISTRY - Vol.91 No.22

<P>In this work, medical diagnosis of sepsis was conducted via quantitative analysis of lysophosphatidylcholine 16:0 (LPC 16:0) by using matrix-assisted laser desorption ionization time-of-flight (MALDI-TOF) mass spectrometry based on a parylene-matrix chip. In the first step, specific mass peaks for the diagnosis of sepsis were searched by comparing MALDI-TOF mass spectra of sepsis patient sera with healthy controls and pneumonia patient sera. Two mass peaks at <I>m</I>/<I>z</I> = 496.3 and 518.3 were chosen as those that are specifically different for sepsis sera to compare with healthy controls and pneumonia patient sera. These mass peaks were identified to be protonated and sodium adducts of LPC 16:0 by using tandem mass spectra (MS<SUP>2</SUP> and MS<SUP>3</SUP>) of purely synthesized LPC 16:0 and extracted LPC 16:0 from a healthy control and a sepsis patient. In the next step, a standard curve for LPC 16:0 for the quantitative analysis of LPC 16:0 with MALDI-TOF MS based on the parylene-matrix chip was prepared, and the statistical correlation to the LC-MS analysis results was demonstrated by using the Bland-Altman test and Passing-Bablok regression. Finally, MALDI-TOF MS based on the parylene-matrix chip was used for the quantification of LPC 16:0 with sera from patients with severe sepsis and septic shock (<I>n</I> = 143), pneumonia patients (<I>n</I> = 12), and healthy sera (<I>n</I> = 31). The sensitivity and the selectivity of medical diagnosis of sepsis was estimated to be 97.9% and 95.5% by using MALDI-TOF MS based on the parylene-matrix chip, respectively.</P> [FIG OMISSION]</BR>

The Role of the Executive Pay Cap: Evidence from Korea

( Sohee Park ),( Natalie Kyung Won Kim ),( Jae Yong Shin ),( Sun-moon Jung ) 한국회계학회 2021 회계학연구 Vol.46 No.2

Korean firms are required to obtain shareholder approval on their executive pay cap―the maximum possible amount of total compensation for all executives. This paper investigates the efficacy of the executive pay cap requirement by analyzing the determinants and implications of the executive pay cap of Korean firms. We document that the executive pay cap is not a boilerplate figure and is associated with corporate governance and economic factors. We find that the executive pay cap is adjusted according to changes in firm performance and that a significant portion of sample firms revise their executive pay cap downwards. However, we only observe this phenomenon when foreign ownership is high, largest shareholders’ ownership is high, a controlling shareholder is a board member, and the firm is a non-chaebol firm. Thus, we find that the external and internal monitoring mechanisms affect whether the executive pay cap is better aligned with firm performance. Our results also suggest that the executive pay cap is used as an anchor for determining executive compensation. We do not find support for the alternative possibility that firms could signal future firm performance through the executive pay cap.

Determinants of the burden and positivity of family caregivers of terminally ill cancer patients in Korea

Park, Chang‐,Hae,Shin, Dong Wook,Choi, Jin Young,Kang, Jina,Baek, Young Ji,Mo, Ha Na,Lee, Mee‐,Sook,Park, Seon‐,Ju,Park, Sang Min,Park, Sohee John Wiley Sons, Ltd 2012 PSYCHOONCOLOGY Vol.21 No.3

<P><B>Abstract</B></P><P><I>Objective</I>: Caregivers may experience positive or negative feelings about their role. The study investigated the determinants of the burden and positivity of family caregivers of Korean terminal cancer patients.</P><P><I>Methods</I>: A multicenter cross‐sectional survey was conducted with 139 family caregivers. Determinants of caregiver's burden and positivity were assessed by the Caregiver Reaction Assessment Scale and by three questions based on a previous study, respectively. Two separate hierarchical multiple regression models were used.</P><P><I>Results</I>: Each domain of the caregiver's burden and positivity was explained by different factors, with the total explained variance ranging between 14.4–33.6% and 2.6–18.3%, respectively. Caregivers who were unmarried, less educated, and/or had low incomes were more likely to be negatively affected, while those who shared caregiving responsibilities were less prone to negative consequences. Caregivers who were male, religious practitioners, and who perceived a higher burden of schedule disruptions were more likely to have a positive perception of their role, while those who perceived a lack of family support were less likely.</P><P><I>Conclusions</I>: Our results highlight the importance of sharing the caregiving burden with the other family members. Organizing a family meeting can provide an opportunity for other family members to acknowledge the feelings and reactions of the primary caregivers, and can prompt the sharing of caregiving responsibilities. Copyright © 2010 John Wiley & Sons, Ltd.</P>

Attribution to Heterogeneous Risk Factors for Breast Cancer Subtypes Based on Hormone Receptor and Human Epidermal Growth Factor 2 Receptor Expression in Korea

Park, Boyoung,Choi, Ji-Yeob,Sung, Ho Kyung,Ahn, Choonghyun,Hwang, Yunji,Jang, Jieun,Lee, Juyeon,Kim, Heewon,Shin, Hai-Rim,Park, Sohee,Han, Wonshik,Noh, Dong-Young,Yoo, Keun-Young,Kang, Daehee,Park, Su Wolters Kluwer Health 2016 Medicine Vol.95 No.14

<▼1><P>Supplemental Digital Content is available in the text</P></▼1><▼2><P><B>Abstract</B></P><P>We conducted a heterogeneous risk assessment of breast cancer based on the hormone receptor (HR) and human epidermal growth factor receptor 2 (HER2) calculating the risks and population-based attributable fractions (PAFs) for modifiable and nonmodifiable factors.</P><P>Using matched case–control study design from the Seoul Breast Cancer Study and the national prevalence of exposure, the risks and PAFs for modifiable and nonmodifiable factors were estimated for total breast cancers and subtypes.</P><P>The attribution to modifiable factors was different for each subtype (luminal A, PAF = 61.4% [95% confidence interval, CI = 54.3%–69.8%]; luminal B, 21.4% [95% CI = 18.6–24.9%]; HER2-overexpression, 59.4% [95% CI = 47.8%–74.3%], and triple negative tumors [TNs], 27.1% [95% CI = 22.9%–32.4%)], and the attribution to the modifiable factors for the luminal A and HER2-overexpression subtypes was higher than that of the luminal B and TN subtypes (<I>P</I> heterogeneity ≤ 0.001). The contribution of modifiable reproductive factors to luminal A type in premenopausal women was higher than that of the other subtypes (18.2% for luminal A; 3.1%, 8.1%, and −3.1% for luminal B, HER2-overexpression, and TN subtypes, respectively; <I>P</I> heterogeneity ≤ 0.001). Physical activity had the highest impact preventing 32.6% of luminal A, 14.5% of luminal B, 38.0% of HER2-overexpression, and 26.9% of TN subtypes (<I>P</I> heterogeneity = 0.014). Total reproductive factors were also heterogeneously attributed to each breast cancer subtype (luminal A, 65.4%; luminal B, 24.1%; HER2-overexpression, 57.9%, and TN subtypes, −3.1%; <I>P</I> heterogeneity ≤ 0.001).</P><P>Each pathological subtype of breast cancer by HRs and HER2 status may be associated with heterogeneous risk factors and their attributable risk, suggesting a different etiology. The luminal B and TN subtypes seemed to be less preventable despite intervention for alleged risk factors, even though physical activity had a high preventable potential against breast cancer.</P></▼2>

Nanosilver Colloids-Filled Photonic Crystal Arrays for Photoluminescence Enhancement

Park, Seong-Je,Lee, Soon-Won,Jeong, Sohee,Lee, Ji-Hye,Park, Hyeong-Ho,Choi, Dae-Geun,Jeong, Jun-Ho,Choi, Jun-Hyuk Springer 2010 Nanoscale research letters Vol.5 No.10

<P>For the improved surface plasmon-coupled photoluminescence emission, a more accessible fabrication method of a controlled nanosilver pattern array was developed by effectively filling the predefined hole array with nanosilver colloid in a UV-curable resin <I>via</I> direct nanoimprinting. When applied to a glass substrate for light emittance with an oxide spacer layer on top of the nanosilver pattern, hybrid emission enhancements were produced from both the localized surface plasmon resonance-coupled emission enhancement and the guided light extraction from the photonic crystal array. When CdSe/ZnS nanocrystal quantum dots were deposited as an active emitter, a total photoluminescence intensity improvement of 84% was observed. This was attributed to contributions from both the silver nanoparticle filling and the nanoimprinted photonic crystal array.</P>

Validation of an Analytical Method for the Determination of Amitraz and Pymetrozine in Organic Farming Materials using QuEChERS Extraction and Liquid Chromatography-tandem Mass Spectrometry

SoHee Park,Hyejin Park,ChaiUk Lim,Kyungeun Yu,Han Sol Lee,Eun Joo Baek,Dogyung Oh,Namkuk Kim,Seong Hun Lee,Sung-Hee Hong 한국농약과학회 2023 한국농약과학회 학술발표대회 논문집 Vol.2023 No.11

In vitro wound healing: Inhibition activity of insect-derived mAb CO17-1A in human colorectal cancer cell migration

Park Se Ra,Ko Kisung,Lim Sohee,Cha So Yeon,정현주,Park Soon Ju,Myung Soon‐Chul,Kim Mi Kyung 한국곤충학회 2020 Entomological Research Vol.50 No.4

The monoclonal antibody (mAb) CO17-1A specifically binds to the tumor associated cell surface glycoprotein GA733 in colorectal cancer cells. Thus, mAb CO17-1A has the potential to act as an immune therapeutic protein against colorectal cancer. Recently, it was shown that the baculovirus insect cell expression system produces anti-colorectal cancer mAb CO17-1A. In this study, the colorectal cancer antibody mAb CO17-1A fused to the endoplasmic reticulum (ER) retention signal sequence (KDEL), and the (mAb CO17-1AK) was expressed in Spodoptera frugiperda Sf9 insect cells. The yield, cell cytotoxicity, and in vitro anti-tumor activity of mAb CO17-1AK were verified. Western blotting was performed to confirm that both heavy and light chains of mAb CO17-1A were expressed in Sf9 insect cells. The insect-derived mAb (mAbI ) CO17-1A was purified using a protein G affinity column. An in vitro wound healing assay was conducted to determine the inhibition activity of mAb CO17-1A during tumor cell migration, showing that mAbI CO17-1AK was effective as mammalian-derived mAb CO17-1A (mAbM CO17-1A). These results suggest that the insect cell expression system can produce and properly assemble mAbs that inhibit tumor cell migration.

Partially Occluded Facial Image Retrieval Based on a Similarity Measurement

Park, Sohee,Lee, Hansung,Yoo, Jang-Hee,Kim, Geonwoo,Kim, Soonja Hindawi Limited 2015 Mathematical problems in engineering Vol.2015 No.-

<P>We present a partially occluded facial image retrieval method based on a similarity measurement for forensic applications. The main novelty of this method compared with other occluded face recognition algorithms is measuring the similarity based on Scale Invariant Feature Transform (SIFT) matching between normal gallery images and occluded probe images. The proposed method consists of four steps: (i) a Self-Quotient Image (SQI) is applied to input images, (ii) Gabor-Local Binary Pattern (Gabor-LBP) histogram features are extracted from the SQI images, (iii) the similarity between two compared images is measured by using the SIFT matching algorithm, and (iv) histogram intersection is performed on the SIFT-based similarity measurement. In experiments, we have successfully evaluated the performance of the proposed method with the commonly used benchmark database, including occluded facial images. The results show that the correct retrieval ratio was 94.07% in sunglasses occlusion and 93.33% in scarf occlusion. As such, the proposed method achieved better performance than other Gabor-LBP histogram-based face recognition algorithms in eyes-hidden occlusion of facial images.</P>