RISS 검색 - 국내학술지논문

1
The Status of Hepatocellular Carcinoma (HCC) in Remote Eastern Mongolia

( Batsukh Dashnyam ),( Nyam Biziya ),( Oyundelger Munkhtuvshin ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
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Aims: The prevalence of HCC is high in Mongolia with men 116.6 cases and women 74.8 cases per 100,000 person-years. HCC counts for the 46% of leading cancers. Dornod Medical Centre, Choibalsan is the major medical center in the three Eastern Provinces. The HCC patients in the Sukhbaatar and Dornod Province count for 3rd and 4th places in Mongolia. Methods: 160 patients were diagnosed to be HCC at the Dornod Medical Centre by using sonography from 2012 to 2014. 86 of them with available serum AFP levels were enrolled and compared. Less than a-half patients had computed tomography (CT) to confirm the HCC. Magnetic Resonance Imaging, angiography, hepatitis markers and liver biopsy are not available in the Dornod Medical Centre. Results: The age of patients was as 46-55 (25.5%), 56 -65 (29%), 66-75 (20.9%) and the greater numbers were patients age 76 and older (16.2%). 44 (51%) of them were male and 42 (49%) were female. There were detected 18 (20.9%) of liver cancer in size < 3 cm, 28 (32%) sized 3-5 cm and 40 (46.5%) sized > 5 cm across. Conclusions: The prevalence of HCC in Eastern Mongolia is high. The laboratory tests and image studies are limited in this region. Most patients are not able to afford the medical expense. The accurate diagnosis and treatment are difficult. Most patients are referred to the capital Ulaanbaatar 700 km far away. Much more resources are in-needed to help the prevention, diagnosis and treatment of HCC in the Eastern Mongolia.
2
Decreased of Alpha-Fetoprotein Level Among Patients with Liver Cirrhosis that Related to HCV Treated with Combination Therapy with Ledipasvir and Sofosbuvir

( Batsukh Dashnyam ),( Bayarmaa Nyamaa ),( Nyam Biziya ),( Oyundelger Munkhtuvshin ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
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Aims: Hepatocellular carcinoma (HCC) is considered one of the most lethal cancers, with most of cases diagnosed at advanced stage. The prevalence of HCC is high in Mongolia with men 116.6 cases and women 74.8 cases per 100,000 person-years. The hepatitis C virus (HCV) infection is one of the major causes of chronic hepatitis and hepatocellular carcinoma (HCC) in Mongolia. Viral infection with HCV can cause fluctuations in AFP that makes it difficult to differentiate between underlying liver disease and the development of HCC. The lack of specificity has limited the role of serum alpha-fetoprotein (AFP) for hepatocellular carcinoma (HCC) screening among patients with cirrhosis related to hepatitis C virus (HCV) infection. Methods: Here we report 25 cases decreased of AFP level in patients with cirrhosis treated 24 weeks combination therapy with ledipasvir and sofosbuvir between 2017 to 2020 were referred to the Liver Unit, Dornod Medical center Mongolia. All patients had been tested for blood chemistries, liver function markers, such as alanine aminotransferase (ALT), total bilirubin, prothrombin, international normalized ratio (INR), creatinine, AFP and HCV-RNA. Results: Of all patients, fifteen were man and ten were woman. The average age of the testimonies was 53 (between 40 and 67 years). All patients had HCV genotype 1b and had HCV-RNA positive. The combination of the therapy with ledipasvir and sofosbuvir had significantly decreased level of HCV-RNA from 2172560 to not detected (P<0.05), ALT from 119.4 to 28.4 (P<0.05), AFP from 42.8 to 12.2 (P<0.05). Conclusions: In conclusion, the combination of the therapy with ledipasvir and sofosbuvir is decreased AFP level and improved liver function tests in HCV related liver Cirrhosis of those patients.
3
Decreased of Alpha-fetoprotein Level Among Patients with Liver Cirrhosis that related to HCV Treated with Combination Therapy with Ledipasvir and Sofosbuvir

( Batsukh Dashnyam ),( Bayarmaa Nyamaa ),( Nyam Biziya ),( Oyundelger Munkhtuvshin ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
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Aims: Hepatocellular carcinoma (HCC) is considered one of the most lethal cancers, with most of cases diagnosed at advanced stage. The prevalence of HCC is high in Mongolia with men 116.6 cases and women 74.8 cases per 100,000 person-years. The hepatitis C virus (HCV) infection is one of the major causes of chronic hepatitis and hepatocellular carcinoma (HCC) in Mongolia. Viral infection with HCV can cause fluctuations in AFP that makes it difficult to differentiate between underlying liver disease and the development of HCC. The lack of specificity has limited the role of serum alpha-fetoprotein (AFP) for hepatocellular carcinoma (HCC) screening among patients with cirrhosis related to hepatitis C virus (HCV) infection. Methods: Here we report 5 cases decreased of AFP level in patients with cirrhosis treated 24 weeks combination therapy with ledipasvir and sofosbuvir between 2017 to 2018 were referred to the Liver Unit, Dornod Medical center Mongolia. All patients had been tested for blood chemistries, liver function markers, such as alanine aminotransferase (ALT), total bilirubin, prothrombin, international normalized ratio (INR), creatinine, AFP and HCV-RNA. Results: Of all patients, 53 were men (44.9%) and 68 were women (56.1%). The avarage age was 44 (between 16 and 70 years). Anti-HDV was positive in 75% (91/121) and all were checked for HDV RNA and 100% were found positive (91/91) all of the patients. HBV-DNA detected in111 all of the 121 patients. Mean HBV-DNA level was 1590177.877 IU/ml. The mean HBV-DNA level in the anti-HDV-positive patients were significantly lower than in the anti-HDV-negative patients (P<0.001). There were 65 patients with cirrhosis (54%) in the study group. Anti-HDV seroprevalence and HDV RNA presence were higher in those with cirrhosis 42 (64%). HDV-RNA-positive patients had significantly higher ALT (94 U/L) levels when compared to HDV-RNA-negative patients. Conclusions: Our study showed hepatitis delta virus infection in HBsAg positive patients who live in Eastern province Mongolia higher than other province of Mongolia.
4
The Prevalence Hepatitis B and C Virus in Eastern Mongolia

( Doljinsuren Enkhbayar ),( Bayarmaa Nyamaa ),( Nyam Biziya ),( Oyundelger Munkhtuvshin ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
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Aims: The prevalence of hepatitis virus high in Mongolia HBV-13%, HCV-11 %, antibody to HDV 13.6% among hepatitis B surface antigen (HBsAg) bearing carriers. In Mongolia HBV, HCV infection is the main factor related to development of HCC. HCC patients in the Dornod Province count for 3rd places in Mongolia.The status of the hepatitis B and C virus in Dornod province remains uninvestigated. Methods: From May 2015 to June 2015, 260 adult patients, who were served by internal medicine outpatient of Dornod Medical Centre. All patients examined for Immunochromatographic 1 step test for Hepatitis B surface antigen, anti-HCV antibody, and liver function test (ALAT, ASAT, bilirubin). Results: Of the 260 subjects, 68 (26%) were positive for HBsAg, and 39 (15.0%) were positive for anti-HCV. HBsAg were distributed almost equally by age: 29% for persons less than 40 years old, 27.9% for those 40-49 years old, 29.0% of those 50-59 years old, and 11.7% of those 60 years old or more. Anti-HCV were distributed almost equally by age: 12.7% for persons less than 40 years old, 30.7% for those 40-49 years old, 25.6% of those 50-59 years old, and 30.7% of those 60 years old or more.In blood chemistry, LFT’s levels were higher in HBsAg positive patients 30 cases (44.1%),anti-HCV antibody positive patients was 16 cases (41%). Conclusions: The prevalence of hepatitis B and C Virus Eastern Province higher than average of Mongolia.

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