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- 저자 : ( Omneya Ali ) (검색결과 1 건)
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( Mohammed Abd Elfattah Darwesh ),( Wessam Arafa ),( Omneya Ali ),( Abdallah Bastawesy ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Hepatic encephalopathy is a syndrome observed in patients with liver cirrhosis and the development of hepatic encephalopathy is explained, to some extent, by the effect of neurotoxic substances, which occurs in the setting of cirrhosis and portal hypertension. Few studies have been conducted to evaluate the risk of smoking in developing hepatic encephalopathy. Methods: This was a cross sectional study of 93 (males=64, females=29) previously diagnosed hepatic patients recently admitted in Alexandria university Main hospital using pretested questionnaire tool. Chi square test of independence and Pearson`s correlation coeffi cient were used to analyze our data. Cox proportional models, stratifi ed by gender, were used to estimate hazard ratios. Results: We have found that 78% of hepatic patients who are smoker have a previous history of overt hepatic encephalopathy with evidence of relation between smoking status and developing hepatic coma (P <. 0001) and the hepatic patients who are smokers had a higher risk of developing hepatic comas than who never smoke (HR 2. 521, 95% CI 1. 197-5. 310) and the risk is found to be higher in females (HR 7. 554, 95% CI 1. 370-41. 652). Smoking pack-years were also associated with increasing the risk of developing hepatic comas (HR 1. 000, 95% CI 0. 993-1. 007). Conclusions: Our fi ndings suggest an evidence of relation between tobacco smoking and development of hepatic comas in known hepatic patients. So, we strongly recommend educating hepatic patients to quit smoking especially female hepatic patients.
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