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Inhibition of Aflatoxin B1 Biosynthesis by Piperlongumine Isolated from Piper Longum L.
( Sung Eun Lee ),( Noreen E. Mahoney ),( Bruce C. Campbell ) 한국미생물 · 생명공학회 2002 Journal of microbiology and biotechnology Vol.12 No.4
The alkaloids, piperlongumine, piperine, pipemonaline, and piperoctadecalidine, isolated from Piper longum L., were found to inhibit the biosynthesis of aflatoxin B1, (AFB1,) in Aspergillus flavus WRRC 3-90-42-12. Piperlongumine was the most active among the compounds tested, with a 96% inhibition of AFB1, biosynthesis at 0.2% (w/v) supplement in a potato dextrose agar (PDA) medium. The three other piperidine alkaloids, piperine, pipemonaline, and piperoctadecalidine, also inhibited the biosynthesis of AFB1. Of these three alkaloids, piperoctadecalidine exhibited a potent inhibitory activity with a 100% inhibition of AFB1, production at 0.7% (w/v) supplement in a PDA medium. Therefore, piperlongumine and piperoctadecalidine could be used as antiaflatoxigenic agents in agricultural industries. To determine the antiaflatoxigenic mode of action of piperlongumine, further studies are needed.