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( Nitesh Pratap ),( Rakesh Kalapala ),( Santosh Darisetty ),( Nitin Joshi ),( Mohan Ramchandani ),( Rupa Banerjee ),( Sandeep Lakhtakia ),( Rajesh Gupta ),( Manu Tandan ),( Nageshwar Reddy ) 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2011 Journal of Neurogastroenterology and Motility (JNM Vol.17 No.1
Background/Aims High-resolution manometry (HRM) with pressure topography is used to subtype achalasia cardia, which has therapeutic implications. The aim of this study was to compare the clinical characteristics, manometric variables and treatment outcomes among the achalasia subtypes based on the HRM findings. Methods The patients who underwent HRM at the Asian Institute of Gastroenterology, Hyderabad between January 2008 and January 2009 were enrolled. The patients with achalasia were categorized into 3 subtypes: type I - achalasia with minimum esophageal pressurization, type Ⅱ - achalasia with esophageal compression and type Ⅲ - achalasia with spasm. The clinical and manometric variables and treatment outcomes were compared. Results Eighty-nine out of the 900 patients who underwent HRM were diagnosed as achalasia cardia. Fifty-one patients with a minimum follow-up period of 6 months were included. Types I and Ⅱ achalasia were diagnosed in 24 patients each and 3 patients were diagnosed as type Ⅲ achalasia. Dysphagia and regurgitation were the main presenting symptoms in patients with types I and Ⅱ achalasia. Patients with type Ⅲ achalasia had high basal lower esophageal sphincter pressure and maximal esophageal pressurization when compared to types I and II. Most patients underwent pneumatic dilatation (type I, 22/24; type Ⅱ, 20/24; type Ⅲ, 3/3). Patients with type Ⅱ had the best response to pneumatic dilatation (18/20, 90.0%) compared to types I (14/22, 63.3%) and Ⅲ (1/3, 33.3%). Conclusions The type Ⅱ achalasia cardia showed the best response to pneumatic dilatation. (J Neurogastroenterol Motil 2011;17:48-53)
( Uday C Ghoshal ),( Kok Ann Gwee ),( Minhu Chen ),( Xiao R Gong ),( Nitesh Pratap ),( Xiao Hua Hou ),( Ari F Syam ),( Murdani Abdullah ),( Young Tae Bak ),( Myung Gyu Choi ),( Sutep Gonlachanvit ),( 대한소화기기능성질환·운동학회 2015 Journal of Neurogastroenterology and Motility (JNM Vol.21 No.1
Background/Aims The development-processes by regional socio-cultural adaptation of an Enhanced Asian Rome III questionnaire (EAR3Q), a cultural adaptation of the Rome III diagnostic questionnaire (R3DQ), and its translation-validation in Asian languages are presented. As English is not the first language for most Asians, translation-validation of EAR3Q is essential. Hence, we aimed to culturally adapt the R3DQ to develop EAR3Q and linguistically validate it to show that the EAR3Q is able to allocate diagnosis according to Rome III criteria. Methods After EAR3Q was developed by Asian experts by consensus, it was translated into Chinese, Hindi-Telugu, Indonesian, Korean, and Thai, following Rome Foundation guidelines; these were then validated on native subjects (healthy [n = 60], and patients with irritable bowel syndrome [n = 59], functional dyspepsia [n = 53] and functional constipation [n = 61]) diagnosed by clinicians using Rome III criteria, negative alarm features and investigations. Results Experts noted words for constipation, bloating, fullness and heartburn, posed difficulty. The English back-translated questionnaires demonstrated concordance with the original EAR3Q. Sensitivity and specificity of the questionnaires were high enough to diagnose respective functional gastrointestinal disorders (gold standard: clinical diagnoses) in most except Korean and Indonesian languages. Questionnaires often uncovered overlapping functional gastrointestinal disorders. Test-retest agreement (kappa) values of the translated questionnaires were high (0.700-1.000) except in Korean (0.300-0.500) and Indonesian (0.100-0.400) languages at the initial and 2-week follow-up visit. Conclusions Though Chinese, Hindi and Telugu translations were performed well, Korean and Indonesian versions were not. Questionnaires often uncovered overlapping FGIDs, which were quite common.