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RISS 인기검색어
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- 저자 : ( Nadiya Boyko ) (검색결과 1 건)
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( Nadiya Boyko ),( Andras Kulja ),( Judit Szabo ),( Victor Petrov ),( Istvan Kalapos ),( Halyna Koval ) 대한소화기학회 2007 SIDDS Vol.9 No.-
Background/Aims: Some probiotic candidated have proven to be effective in increasing human resistance to nosocomial pathogens. The aim of this study was to determine the possible cellular and humoral mechanisms of bacteriological protection and therapy against opportunistic agents. Methods: Opportunistic pathogens isolated form patients of gastrointestinal clinical division were identified by biochemical properties. The resistance to antibiotics was the marker of their congeniality. Antibacterial properties of the representatives Lactobacilli, Escherichia, Bacillus and Morganella genera against opportunistic pathogens were tested in vitro and in vivo. Moncassociated and co-colonized genetically different mouse models were used for studying the role of various subsets of innate and adaptive immune cells in the generation of specific immune responses to bacterial antigens and pathogenic agents at the mucosal surface. RIA, FACS qRT-PCR assays were performed. Results: The nosocomial agents were represented by Enterobacer cloaceae, Klebsiella pneumoniae, K. oxytoca, Pseudomonas aeruginosa, Bacteroides spp. and Staphylococcus aureus (MRSA) strains. Schaedler E.coli and M.morganii demonstrated the highest inhibition activity against both Klebsiella species in vitro and in vivo. All MRSA strains were completely inhibited by Bacillus subtilis under their in vitro co-cultivation. Lactobacilli strain shows rather moderate effectiveness against investigated clinical isolates. Specific stimulation of B1 cells, IFN-gamma production by IEL-NK cells, increasing of IgAs, IgG2a, IgG2b level in gut compartments and Reg III-beta and gamma secretion by colonic epithelial cells are main regulatory mechanisms providing the first line defense stimulated by commensal representatives against opportunistic enteric pathogens. Conclusions: Commensal flora could specifically protect the host against some dangerous opportunistic pathogenic agents.
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