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Park, Shi-Young,Seo, Soo Boon,Lee, Soo-Jung,Na, Jong-Gil,Kim, Yung-Jin 부산대학교 유전공학연구소 2001 분자생물학 연구보 Vol.17 No.-
Sodium tolerance in yeast is enhanced by continuous activation of calcineurin, a Ca^2+/calmodulin-dependent protein phosphatase that is required for modulation of the Na^+ efflux mechanism. We isolated several salt-tolerant mutations with the treatment of ethylmethane sulfonate under high salt stress. One of the mutations was mapped in the PMR1 gene. Pmr1p, the P-type Ca^2+ -ATPase in the Colgi apparatus, regulates a cytosolic Ca^2+ level in various responses. Cytosolic Ca^2+ concentration in the pmr1 mutant is highly maintained, and thus calcineurin is activated continuously. The treatment of FK506, a specific inhibitor of calcineurin, abolishes the salt-tolerant phenotype of the pmr1 mutant. Activates caicineurin induces the expression of PMR2, encoding the P-type Na^+-ATPase, through the specific transcription factor, Tcn1p/Crzlp. Also, experssion of the PMR2::lacZ reporter gene in the pmr1 higher than that in wild type. We propose that the pmr1 mutation confers salt tolerance through continuous activation of calcineurin and that Pmr1p might act as a major Ca^2+-ATPase under high salt stress.
Na Wang,Xiujuan Dong,Dandan Shi,Na Li,Qun Zhang 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.7
Gestational diabetes mellitus (GDM) is a conditionaldiabetes which is defined as any degree of glucoseintolerance or high blood glucose levels during any phase ofpregnancy. It causes chronic severe damage to health of thepregnant women and their offspring. In this study, we aimedto study the protective effects of Cryptotanshinone on GDMrelatedimpairments. We measured blood glucose levels,serum insulin levels, biochemical indexes, oxidative stress,inflammation and the activation of NF-κB signaling pathwayin the blood and placenta of GDM mice. It is found thatCryptotanshinone significantly decreased blood glucose levels,oxidative stress, inflammation and NF-κB signaling withan increase of serum insulin levels in the placenta and bloodof GDM mice. Taken together, Cryptotanshinone effectivelyameliorated GDM, which suggested that Cryptotanshinone could be served as a promising therapeutic drug for GDMpatients.
The Research of Slots Allocation on Bridge Mode
Shi Li-na,Wan Li-li,Jiang Bing 보안공학연구지원센터 2016 International Journal of Smart Home Vol.10 No.9
Air transport worldwide is growing much more rapidly than the current airport systems’ capacity. This creates somewhat of a crisis for modern commercial aviation. In order to reduce congestion and delays, slots and slots allocation concepts had been put on for many years, but as the most scarce resources, all airlines wish get much slots as possible, So bridge mode was applied by the most areas. We analyzed differences of the slots allocation between in the bridge mode and in the traditional mode, and studied the slots allocation algorithm considering the minimum total delay rate. This paper approved the slots allocation algorithm could reduce the total delay and increase the flights volume, and showed a practical significance.
Ling-Na Shi,Xue-Zhong Li,Lan-Tong Cui,Peng-Fei Wang,Ying Xie,Ting-Feng Yi 한국공업화학회 2022 Journal of Industrial and Engineering Chemistry Vol.114 No.-
Developing well-behaved electrode materials is crucial for manufacturing high-performance batteries,SCs and electrocatalysis, and it is also one of the main driving forces for the development of EES devices. In consideration of the high robustness and electrical conductivity during the electrochemical reactionprocess, VN-based materials exhibit good performance as electrode materials (or catalytic materials)for batteries, supercapacitors, and excellent catalytic activity for electrocatalysts. Especially, the VNbasedmaterials decorated into other active compounds with various morphologies elaborately presentexcellent performances due to the abundant active sites and fully synergistic effect. This review presentsthe structure-performance relation by designing different-dimensional nanostructures and various applicationsof VN-based materials in electrochemical energy storage (EES) applications. Finally, the perspectiveson future challenges and progress have been discussed. This review can offer a specificunderstanding for the optimization strategies of VN-based materials, thus booming the rapid developmentand practical applications for EES devices in the future.
Susceptibility Loci Associations with Prostate Cancer Risk in Northern Chinese Men
Wang, Na-Na,Xu, Yong,Yang, Kuo,Wei, Dong,Zhang, Yao-Guang,Liu, Ming,Shi, Xiao-Hong,Liang, Si-Ying,Sun, Liang,Zhu, Xiao-Quan,Yang, Yi-Ge,Tang, Lei,Zhao, Cheng-Xiao,Wang, Xin,Chen, Xin,Hui, Juan,Zhang, Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5
Background: KLK3 gene products, like human prostate-specific antigen (PSA), are important biomarkers in the clinical diagnosis of prostate cancer (PCa). G protein-coupled receptor RFX6, C2orf43 and FOXP4 signaling plays important roles in the development of PCa. However, associations of these genes with PCa in northern Chinese men remain to be detailed. This study aimed to investigate their impact on occurrence and level of malignancy. Methods: All subjects were from Beijing and Tianjin, including 266 cases with prostate cancer and 288 normal individuals as controls. We evaluated associations between clinical covariates (age at diagnosis, prostate specific antigen, Gleason score, tumor stage and aggressive) and 6 candidate PCa risk loci, genotyped by PCR- high resolution melting curve and sequencing methods. Results: Case-control analysis of allelic frequency of PCa associated with PCa showed that one of the 6 candidate risk loci, rs339331 in the RFX6 gene, was associated with reduced risk of prostate cancer (odds ratio (OR) = 0.73, 95% confidence interval (CI) =0.57-0.94, P = 0.013) in northern Chinese men. In addition, subjects with CX (CC+TC) genotypes had a decreased risk for prostrate cancer compared to those carrying the TT homozygote (OR =0.64, 95% CI = 0.45- 0.90, P = 0.008). The TT genotype of 13q22 (rs9600079, T) was associated with tumor stage (P=0.044, OR=2.34, 95% CI=0.94-5.87). Other SNPs were not significantly associated with clinical covariates in prostate cancer (P > 0.05). Conclusions. rs339331 in the RFX6 gene may be associated with prostate cancer as a susceptibility locus in northern Chinese men.
자이로 센서를 이용한 이동로봇 Odometry 오차 보정에 관한 연구
朴恃拏(Shi-Na Park),洪顯珠(Hyun-Ju Hong),崔愿太(Won-Tae Choi) 대한전기학회 2006 전기학회논문지 D Vol.55 No.2
To make the autonomous mobile robot move in the unknown space, we have to know the information of current location of the robot. So far, the location information that was obtained using Encoder always includes Dead Reckoning Error, which is accumulated continuously and gets bigger as the distance of movement increases. In this paper, we analyse the effect of the size of the two wheels of the mobile robot and the wheel track of them among the factors of Dead Reckoning Error. And after this, we compensate this Dead Reckoning Error by Kalman filter using Gyro Sensors. To accomplish this, we develop the controller to analyse the error components of Gyro Sensor and to minimize the error values. We employ the numerical approach to analyse the error components by linearizing them because each error component is nonlinear. And we compare the improved result through simulation.