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RISS 인기검색어
- 검색키워드
- 저자 : ( Munazza Fatima ) (검색결과 4 건)
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Spatial and temporal analysis of acute respiratory infections (ARIs) in Southern Punjab, Pakistan
Munazza Fatima,Rehman Mehmood Khattak,Sue. C. Grady,Ibtisam Butt,Sana Arshad,Till Ittermann,Henry Volzke 대한공간정보학회 2022 Spatial Information Research Vol.30 No.4
Acute Respiratory Infections (ARI) is a main health issue of Pakistan. This study deals to visualize the spatial distribution of ARIs in first instance and further to investigate their underlying temporal pattern in Bahawalpur district of Southern Punjab Pakistan. The main purpose is to measure spatial patterns of ARIs which might be helpful for better understanding its environmental determinants and leads to hypothesis generation for further investigation. Study design selected to conduct this research is of descriptive and exploratory nature. Epidemiological data of ARIs was collected mainly through 115 health centres from the study area for year 2010 to 2012 and was used to map spatial patterns of ARIs through Inverse distance weighted (IDW) spatial interpolation and Spatial Autocorrelation and Cluster Outlier Analysis. Results show that the clusters of ARIs were found mainly around urban units of tehsils. The study also suggests the set of remedies and policy changes addressing the local environmental problems and to reducing the incidence of ARIs through collaboration of local government and community.
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( Munazza Fatima ),( Najam Us Sahar Sadaf Zaidi ),( Deeba Amraiz ),( Farhan Afzal ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.1
Nanoparticles have wide-scale applications in various areas, including medicine, chemistry, electronics, and energy generation. Several physical, biological, and chemical methods have been used for synthesis of silver nanoparticles. Green synthesis of silver nanoparticles using plants provide advantages over other methods as it is easy, efficient, and eco-friendly. Nanoparticles have been extensively studied as potential antimicrobials to target pathogenic and multidrug-resistant microorganisms. Their applications recently extended to development of antivirals to inhibit viral infections. In this study, we synthesized silver nanoparticles using Cinnamomum cassia (Cinnamon) and evaluated their activity against highly pathogenic avian influenza virus subtype H7N3. The synthesized nanoparticles were characterized using UVVis absorption spectroscopy, scanning electron microscopy, and Fourier transform infrared spectroscopy. Cinnamon bark extract and its nanoparticles were tested against H7N3 influenza A virus in Vero cells and the viability of cells was determined by tetrazolium dye (MTT) assay. The silver nanoparticles derived from Cinnamon extract enhanced the antiviral activity and were found to be effective in both treatments, when incubated with the virus prior to infection and introduced to cells after infection. In order to establish the safety profile, Cinnamon and its corresponding nanoparticles were tested for their cytotoxic effects in Vero cells. The tested concentrations of extract and nanoparticles (up to 500 μg/ml) were found non-toxic to Vero cells. The biosynthesized nanoparticles may, hence, be a promising approach to provide treatment against influenza virus infections.
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Current development of therapeutic vaccines for the treatment of chronic infectious diseases
Park Pil-Gu,Fatima Munazza,An Timothy,Moon Ye-Eun,Woo Seungkyun,Youn Hyewon,Hong Kee-Jong 대한백신학회 2024 Clinical and Experimental Vaccine Research Vol.13 No.1
Chronic infectious diseases refer to diseases that require a long period of time from onset to cure or death, the use of therapeutic vaccines has recently emerged to eradicate diseases. Currently, clinical research is underway to develop therapeutic vaccines for chronic infectious diseases based on various vaccine formulations, and the recent success of the messenger RNA vaccine platform and efforts to apply it to therapeutic vaccines are having a positive impact on conquering chronic infectious diseases. However, since research on the development of therapeutic vaccines is still relatively lacking compared to prophylactic vaccines, there is a need to focus more on the development of therapeutic vaccines to overcome threats to human health caused by chronic infectious diseases. In order to accelerate the development of therapeutic vaccines for chronic infectious diseases in the future, it is necessary to establish a clear concept of therapeutic vaccines suitable for the characteristics of each chronic infectious disease, as well as standardize vaccine effectiveness evaluation methods, secure standards/reference materials, and simplify the vaccine approval procedure.
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Safina Ghaffar,Shabbir Khan Afridi,Meha Fatima Aftab,Munazza Murtaza,Rahman M. Hafizur,Sara Sara,Sabira Begum,Rizwana Sanaullah Waraich 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.4
Several reports indicate anti-hyperglycemic effects of Syzygium aromaticum. In the present study, we report for the first time that clove extract (SAM) and its compound nigricin (NGC) decreases free fatty acid-mediated insulin resistance in mouse myoblasts. In addition, NGC was able to diminish insulin resistance in a diabetic mouse model. We observed that SAM and its compound NGC exhibited significant antioxidant activity in murine skeletal muscle cells. They also modulated stress signaling by reducing p38 MAP kinase phosphorylation. NGC and SAM treatments enhanced proximal insulin signaling by decreasing serine phosphorylation of insulin receptor substrate-1 (IRS-1) and increasing its tyrosine phosphorylation. SAM and NGC treatments also modified distal insulin signaling by enhancing protein kinase B (PKB) and glycogen synthase kinase-3-beta (GSK-3 beta) phosphorylation in muscle cells. Glucose uptake was enhanced in muscle cells after treatment with SAM and NGC. We observed increased glucose tolerance, glucose-stimulated insulin secretion, decreased insulin resistance, and increased beta cell function in diabetic mice treated with NGC. The results of our study demonstrate that clove extract and its active agent NGC can be potential therapeutic agents for alleviating insulin resistance.
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