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RISS 인기검색어
- 검색키워드
- 저자 : ( Mukunda Raj Kalouni ) (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Liver Hydroxylation of Vitamin D and Its Relationship to Autoimmune Thyroid Disease
( Mukunda Raj Kalouni ),( Bhup Dev Bhatta ),( Dhruba Acharya ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: 25 hydroxy vitamin D is synthesized in the liver by microsomal enzyme 25-hydroxylase. Vitamin D is associated with autoimmune thyroid disease. Recently its role in the immune modulator has been discovered. The aim of the study was to evaluate the relationship between 25 hydroxy vitamin D and thyroperoxidase (TPO) antibody. Methods: 200 subjects were enrolled in this study, among them 100 were study group and 100 were healthy control group during june 2014 to may 2016. Serum levels of anti TPO antibody, 25 hydroxy vitamin D, thyroid stimulating hormone, free thyroxine and free tri-iodothyronine were measured by chemiluminiscence immuno assay (CLIA, maglumi 1000) Results: We found a statistically significant correlation between 25 hydroxy vitamin D and thyroperoxidase antibody (p= <0.001). Study group had lower levels of vitamin D than control group 21.86 ± 8.41 and 32.27 ± 11.75 respectively.( p= <0.001). Serum 25 hydroxy vitamin D was inversely correlated with antithyroperoxidase antibody (r = -0.318, p= < 0.001). Study group had higher TPO antibody levels as compared to control group. Conclusions: Our study suggests that vitamin D deficiency was significantly associated with autoimmune thyroid disease. It also found that patients with autoimmune thyroid disease had lower levels of 25 hydroxy vitamin D. We also found a negative correlation between TPO antibody and Vitamin D.
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Diagnostic Value of Transaminases and Deritis Ratio for Predicting Alcoholic Liver Disease
( Mukunda Raj Kalouni ),( O. P. Talwar ),( Saroj Pokhrel ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Alcoholic liver disease is a major public health concern in Nepal. Excess alcohol consumption leads to alcoholic liver dis eases. The use of test combinations significantly improves the information received with single serum enzyme determinations. Aspartate aminotransferase to alanine aminotransferase ratio (deritis ratio) is a diagnostic marker in alcoholic liver disease. The aim of the study is to rule out significance of transaminases and deritis ratio in alcoholic liver disease subjects. Methods: The study was carried out in the department of bio chemistry at Manipal Teaching Hospital, and kaski Sewa Hospital and Research Center Pokhara, Nepal between 5<sup>th</sup> October 2017 to 15<sup>th</sup> March 2018. Clinically 50 known cases of alcoholic liver disease patients and 50 healthy individuals were enrolled in this study. The correlations of the variables were evaluated by pear son correlation coefficient. Descriptive statistics were used for analysis of the results. Data was analyzed by using SPSS version 17. P values of < 0.05 were considered statistically significant. Results: We found a significant difference between Trans aminases between alcoholic liver disease patients and healthy control subjects. The mean value of AST (111.98 ± 124.05) was found to be highly increased incomparision to ALT (61.26 ± 43.86) leading to significantly higher AST/ALT ratio (1.95 ± 1.42). The mean values of deritis ratio was 1.95 in ALD patients which was markedly increased as compared to the ratio of controls (1.13). There were significant differences in the AST/ ALT ratio between two groups (P=0.000). Patients with alcohol ic liver disease had an AST:ALT ratio > 1.0. Conclusions: This study suggests that high deritis ratio is the marker for alcoholic liver disease. An elevated serum AST in relation to serum ALT has been proposed as an indicator that alcohol has induced organ damage
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Study of Serum Gamma Glutamyl Transferase (GGT) Ac tivity as a Biomarker in Alcoholic Liver Disease
( Saroj Pokhrel ),( Mukunda Raj Kalouni ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Alcoholic liver diseases arise from the excessive ingestion of alcohol. It is the major cause of liver cirrhosis all over the world. It can be prevented by early diagnosis and management. Various biomarkers and enzymes are available for the diagnosis of alcoholic liver diseases. The aim of the study is to evaluate the role GGT in the diagnosis of alcoholic liver disease. Methods: This study was conducted at Kaski Sewa Hospital and Research Centre between 2<sup>nd</sup> December 2017 to 15<sup>th</sup> March 2018. A total of 100 subjects were included in this study out of which 50 were alcoholic liver disease patients and 50 were healthy control subjects. Gamma glutamyl transferase activity was measured for all the subjects. The results were expressed as mean ± SD. The comparison between the two groups were evaluated by Pearson correlation coefficient. Sta tistical analysis were done by using Statistical package for social sciences version 17.0. A p values of less than 0.05 were consid ered statistically significant. Results: The mean age of the study subjects was 48.62 ± 16.3. Male and female percentage was 71 % and 29 % respectively. A significant correlation was found between the alcoholic liver disease patients and healthy control subjects. The mean values for GGT was markedly increased 155.13 ± 117.31 as compared to healthy subjects ( 26.86 ± 10.86) which was statistically sig nificant (P=0.000). Conclusions: This study suggested that serum level of gamma glutamyl transferase activity is helpful in the assessment and diagnosis of alcoholic liver disease.
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