Development of a simultaneous multi-residue analysis for screening and confirmation of 7 veterinary drugs in bovine milk by LC-MSMS

MinKyoung Kim,NamSun Kim,HyunJung Kwon,SungYong Ha,HeeSun Kim,JongWon Kim 한국예방수의학회 2019 예방수의학회지 Vol.43 No.2

A simple and fast analytical method based on liquid chromatography-tandem mass spectrometry was developed for detection of the veterinary drugs acetanilide, anthranilic acid, antipyrine, cyproheptadine, diphenhydramine, DLmethylephedrine, and phenacetin in bovine milk. The target analytes were extracted from milk samples by using acetonitrile followed by clean-up with C18 and liquid-liquid purification with saturated n-hexane. A reverse-phase analytical column was employed with a mobile phase comprising (A) 0.1% formic acid in distilled water and (B) 0.1% formic acid in acetonitrile to achieve the best chromatographic separation. Matrix-matched calibration curves (r2 ≥ 0.9986) were constructed using six concentrations (1, 2, 5, 10, 20, and 40 μg/kg) of drugs in the milk matrix. Recoveries at three drug-spiking levels (5, 10, and 20 μg/kg) ranged from 71.2% to 103.8% with intra-day and inter-day relative standard deviation (RSD) values of ≤ 8.6%. The calculated limits of quantification (LOQ) were 0.19-7.1 μg/kg.

Analysis of Research Trends in South Korean ODA for Ethiopia (2000-2015)

Kim HyunJae,Shon Mi,Kim YoungHwan,Park MinKyoung APEC국제교육협력원 2015 Asia-Pacific Cybereducation Journal Vol.11 No.2

The purpose of this study is to analyze the research trends in the South Korean Official Development Assistance (ODA), by examining the papers of degree thesis papers, project reports, and academic journals published from 2000 to 2015, as well as investigating and proposing the themes for future studies. According to the rubrics of analysis, from numerous papers, twelve thesis, twelve reports and eight academic journals were selected and considered following five analysis criteria; namely, published year, stakeholder of study, project procedure, methodology, and relevance to MDGs, the Millennium Development Goals. The results of the analysis are as follows: first, the papers associated with South Korean ODA for Ethiopia were published in 2008 for the first time. With steadily increasing numbers of thesis, reports, and journals, following after 2008, researches have conducted studies vigorously since 2011. However, investigations on the South Korean ODA for Ethiopia are noticeably insufficient, in comparison to the grant aids and concessional loans paid thus far. Secondly, the analysis appeared in twelve papers published by universities, eleven by government authorities, and eight by specialty magazines. Upon closer inspection, the government authority indicated Korea International Cooperation Agency (KOICA), and eight other specialty magazines, as well as the following: Korea Water Resources Association2), Korean Association of African Studies3), Korea Society of Agricultural Extension4), Korean Journal of Health Education and Promotion5), Journal of International Collaboration in Education6), Korea Research Society for Customs7),Perspectives in Nursing Science, The Women’s Studies8). Third, project procedure utilized as the criteria for the analysis. As a result, one feasibility study conducted in 2012 and 2013, one planning study in 2008 and 2010, two planning studies in 2013, one evaluation study in 2011 were identified. However, each project procedure paper for the 25 projects launched thus far were difficult to find. Papers for those have no relevance with ODA projects, and were considered as other studies. Fourth, papers relevant to the MDGs stand as such; 11 papers were linked with MDG 2, ‘Achieve universal primary education’. Three papers had relevance to MDG 1, ‘Eradicate extreme poverty and hunger’, one to MDG 3, ‘Promote gender equality’, three to MDG 5, ‘Improve maternal health’, four to MDG 6, ‘Combat HIV/AIDS malaria, and other diseases’, two to MDG 7, ‘Ensure environmental sustainability’, seven to MDG 8, ‘Develop a global partnership for development’. There were no papers connected with MDG 4, ‘Reduce child mortality’. Therefore, based on this trend analysis, broader spectrums and diverse methods of study should be implemented for the future studies with regard to the South Korean ODA for Ethiopia.

호혜적 개발협력을 위한 주요 국가의 STI 시스템 분석 및 협력방향 - 브라질, 인도를 중심으로 -

김왕동(Wangdong Kim),임덕순(Deok Soon Yim),선인경(Inkyoung Sun),김은주(Eun Joo Kim),이다은(Daeun Lee),유제현(Jehyun Yu),이정원(Jung-won Lee),김기국(Ki-Kook Kim),최용인(Yongin Choi),김원호(Wonho Kim),조충제(Chungje Jo),박민경(Minkyoung P 과학기술정책연구원 2021 정책연구 Vol.- No.-

Reciprocal development cooperation refers to “all activities in the public and private sectors that benefit the donor country’s national interest as well as poverty eradication and economic and social development in the recipient country”. The Korean governments development cooperation paradigm is expected to gradually shift from a humanitarian level to a reciprocal level. However, in the case of science and technology innovation, it is difficult to acquire information about countries that are subject to reciprocal development cooperation. Therefore, in this study, the conceptual framework for reciprocal development cooperation was established and STI systems of major countries were analyzed to provide basic STI data and to suggest directions for reciprocal development cooperation. In this study, two countries, Brazil and India, were selected for analysis by applying three criteria: “differentiation from existing research,” “relevance to national interests and national tasks,” and “possibility of securing data”. In this study, the STI system components of Brazil and India were classified and analyzed into macro-environment, STI governance, STI investment and achievements, STI human resources, STI innovative actors, and STI support organizations. The reciprocal development cooperation agenda was described focusing on three dimensions: “what”, “how” and “who”. First, in the perspective of “what”, climate change, digital transformation, infectious diseases, and other issues were derived as cooperation contents. Second, policy advice and joint research, human exchange, and so on, were suggested as cooperation methods. Third, universities, GRIs, and companies were suggested as cooperation partners. Brazils STI system is characterized by a weak national R&D budget, excellent research manpower and strong basic research, lack of connection and creation of innovation demand between universities and companies, weak industrial competitiveness, lack of science and technology policy and strategy, policy implementation, and coordination of inefficiency and slow-step administration. The characteristics of the Indian STI system include inefficient governance and lack of interconnection led by the government, insufficient investment in STI between the government and the private sector, abundant STI manpower and global talent, the pursuit of R&D activities centered on universities and public research institutes rather than the private sector, bureaucratic and bureaucratic An inefficient STI support organization was identified. In-depth interviews and consultations were conducted with experts from each country to derive the Korea-Brazil development cooperation agenda and the Korea-India development cooperation agenda. The interview and advisory groups were largely divided into policymakers(public officials) for each country, researchers(researchers and professors), and local experts(embassies and dispatchers). The detailed agenda contents are described in Chapters 6 and 7. This study is expected to contribute to the theoretical construction of the field of development cooperation, and to the derivation of the governments Korea-Brazil and Korea-India STI cooperation agenda. The study also can contribute to the demand for STI system information of Brazil and India. However, this study has limitations in responding to more demand by the government by selecting Brazil and India as two countries for reciprocal development cooperation. Therefore many more countries besides Brazil and India should be explored in the future. In addition, in order to improve the reliability and validity of the STI cooperation agenda between Korea-Brazil and Korea-India, interviews and consultations with more experts are required.

Prevalence and Characteristics of Neuropathic Pain in Patients With Spinal Cord Injury Referred to a Rehabilitation Center

Hae Young Kim,Hye Jin Lee,Tae-lim Kim,EunYoung Kim,Daehoon Ham,Jaejoon Lee,Tayeun Kim,Ji Won Shin,Minkyoung Son,Jun Hun Sung,Zee-A Han 대한재활의학회 2020 Annals of Rehabilitation Medicine Vol.44 No.6

Objective To identify the prevalence and characteristics of neuropathic pain (NP) in patients with spinal cord injury (SCI) and to investigate associations between NP and demographic or disease-related variables. Methods We retrospectively reviewed medical records of patients with SCI whose pain was classified according to the International Spinal Cord Injury Pain classifications at a single hospital. Multiple statistical analyses were employed. Patients aged <19 years, and patients with other neurological disorders and congenital conditions were excluded. Results Of 366 patients, 253 patients (69.1%) with SCI had NP. Patients who were married or had traumatic injury or depressive mood had a higher prevalence rate. When other variables were controlled, marital status and depressive mood were found to be predictors of NP. There was no association between the prevalence of NP and other demographic or clinical variables. The mean Numeric Rating Scale (NRS) of NP was 4.52, and patients mainly described pain as tingling, squeezing, and painful cold. Females and those with below-level NP reported more intense pain. An NRS cut-off value of 4.5 was determined as the most appropriate value to discriminate between patients taking pain medication and those who did not. Conclusion In total, 69.1% of patients with SCI complained of NP, indicating that NP was a major complication. Treatment planning for patients with SCI and NP should consider that marital status, mood, sex, and pain subtype may affect NP, which should be actively managed in patients with an NRS ≥4.5.

Biogeochemical properties of sinking particles in the southwestern part of the East Sea (Japan Sea)

Kim, Minkyoung,Hwang, Jeomshik,Rho, TaeKeun,Lee, Tongsup,Kang, Dong-Jin,Chang, Kyung-Il,Noh, Suyun,Joo, HuiTae,Kwak, Jung Hyun,Kang, Chang-Keun,Kim, Kyung-Ryul Elsevier 2017 Journal of marine systems Vol.167 No.-

<P><B>Abstract</B></P> <P>This study investigates the biological pump system in the East Sea (Japan Sea) by conducting an analysis of the total particle flux, biogenic material composition, and carbon isotope ratios of sinking particles. The samples were collected for one year starting from March 2011 using time-series sediment traps deployed at depths of 1040m and 2280m on bottom-tethered mooring at Station EC1 (37.33°N, 131.45°E; 2300m water depth) in the Ulleung Basin (UB), southwestern part of the East Sea. The temporal variation in the particulate organic carbon (POC) flux at 1000m shows a good relationship with the primary production in the corresponding surface water. The ratio of POC flux at 1000m to satellite-based primary production in the corresponding region in the UB was ~3%, which is comparable to the values of 2 to 5% estimated from previous studies of other part of the East Sea. The lithogenic material accounted for >17% of the sinking particles at 1000m and for a larger fraction of 40 to 60% at 2280m. The radiocarbon contents of the sinking POC at both trap depths imply the additional supply of aged POC, with a much greater contribution at 2280m. Overall, the particle flux in the deep interior of the East Sea appears to be controlled by the supply of complex sources, including aeolian input, the lateral supply of resuspended sediments, and biological production in the surface water.</P> <P><B>Highlights</B></P> <P> <UL> <LI> POC flux variation at 1000m shows a good relationship with the primary production. </LI> <LI> The ratio of POC flux at 1000m to primary production was ~3% in the UB. </LI> <LI> The particle flux in the East Sea appears to be controlled by complex sources. </LI> </UL> </P>

An Investigation of Gas Exchange and Water Circulation in the Amundsen Sea Based On Dissolved Inorganic Radiocarbon

Kim, Bumsoo,Lee, SangHoon,Kim, Minkyoung,Hahm, Doshik,Rhee, Tae Siek,Hwang, Jeomshik American Geophysical Union 2018 Geophysical research letters Vol.45 No.22

Study on melting and crystallization of PHBHx thin films using IR and 2D correlation spectroscopy

Kim Minkyoung,Noda Isao,박연주 대한화학회 2022 Bulletin of the Korean Chemical Society Vol.43 No.1

The thermal behavior of poly(hydroxybutyrate-co-hydroxyhexanoate) (PHBHx) thin films having various molar fractions of hydroxyhexanoate (Hx) was investigated using IR, 2D gradient mapping, 2D correlation spectroscopy (2D-COS), and multivariate curve resolution (MCR) analysis. The melting and crystallization temperatures were determined using 2D gradient mapping. The 2D-COS combined with MCR analysis provided information on the unambiguous components that appeared in PHBHx thin films during the melting and crystallization processes.

Effects of Resistance Circuit Training on Health-Related Physical Fitness in People With Paraplegia: A Pilot Randomized Controlled Trial

Minkyoung Son,Hyejin Lee,Bum-Suk Lee,EunYoung Kim,Hyeyeong Yun,Seck Jin Kim,김재학,Seung-Mo Jin,Seon-Deok Eun 대한재활의학회 2022 Annals of Rehabilitation Medicine Vol.46 No.2

Objective To evaluate the efficacy and safety of 8 weeks of resistance circuit training in people with paraplegia due to spinal cord injury. Methods Participants were randomized into experimental and control groups. Although the intensity and sequence of movements of the exercise programs were identical in both groups, the resting time between sets was limited to 1 minute in the experimental group. In the control group, the participants were allowed to rest until they were comfortable. Both groups received 8 weeks of training twice per week. Before and after the program, muscle mass, body fat percentage, fat mass, blood pressure, heart rate, muscle strength and muscular endurance were evaluated, and 6-minute propulsion test was conducted. Additionally, the safety of the program was assessed. Results Twenty-two individuals with paraplegia were enrolled (11 in each group). After the training program, the experimental group showed a significant decrease in the resting blood pressure and improvement in the upper extremity muscle mass, strength, and endurance (p<0.05). Each variable showed significant inter-group differences (p<0.05). Furthermore, none of the participants showed autonomic adverse events, musculoskeletal side effects, or discomfort. Conclusion The results show that resistance circuit training programs with short resting intervals are superior to the usual resistance exercise programs in improving the blood pressure and physical strength and are safe for people with upper thoracic level injuries at T6 or higher.

Environmental Variability and Chum Salmon Production at the Northwestern Pacific Ocean

Kim, Suam,Kang, Sukyung,Kim, Ju Kyoung,Bang, Minkyoung Springer Science + Business Media 2017 OCEAN SCIENCE JOURNAL Vol.52 No.4

An Investigation of the Sample Rotation Effects on Suppression of Convective Flows in PGSE Diffusion NMR Experiments

Kim, Minkyoung,Chung, Kee-Choo 한국자기공명학회 2016 Journal of the Korean Magnetic Resonance Society Vol.20 No.2

Undesirable convective flow in an NMR tube inhibits the accurate measurement of diffusion coefficients by NMR spectroscopy. To minimize the convection effects, various methods have been suggested, and it has been known that the use of sample rotation can be useful. However, it has not been clearly examined that the convection suppressing effect of the sample rotation under the different spinning speeds. In this study, the relation between convective flow and the sample rotation was investigated using PGSE NMR diffusion experiments to reveal the feasibility for controlling the convective flow in an NMR tube by sample rotation itself. The viscosity effect was also examined using solvents with four different viscosities, acetone-$d_6$ chloroform-d, pyridine-$d_5$, and $D_2O$. The sample rotation showed apparent convection suppressing effects at all temperature range for the low viscosity solvents, acetone-$d_6$ and chloroform-d, even at the faster than 5 Hz spinning rate. The similar patterns were also observed for pyridine-$d_5$ and $D_2O$, which have higher viscosity. This effect was observed even at high temperatures where convective flow arises conspicuously.