Periprostetic Joint Infection Caused by Salmonella: Case Reports of Two Azathioprine and Prednisolone Induced-immunocompromised Patients

( Mehmet Ekinci ),( Serkan Bayram ),( Turgut Akgul ),( Mehmet Ersin ),( Onder Yazicioglu ) 대한고관절학회 2017 Hip and Pelvis Vol.29 No.2

Periprosthetic joint infection (PJI) due to Salmonella is rare. It frequently occurs patients receiving immunosuppressive medicine. We describe two periprosthetic Salmonella infection of two immunocompromised patients. Both of patients were receiving azathioprine and prednisolone therapy. First patient presented six years after total hip arthroplasty with a huge abscess on her right thigh that was reached to femoral component through the lytic area of lateral femur. Second patient presented with drainage from his hip and he had undergone two-step revision surgery for PJI 3 months ago. There is no consensus in the treatment of periprosthetic salmonella infections. We prefer two-step revision surgery for these infections as previously described in the literature.

Effect of Cutting Tool Materials on Surface Roughness and Cutting Forces in Machining of Composite Produced by Powder Metallurgy

Ozcatalbas Yusuf,Bahceci Ersin,Turker Mehmet 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1

Aluminum-based composites reinforced with various amounts of were produced by powder metallurgy (P/M). The machinability properties of were determined by means of cutting forces and surface roughness. Machining tests were carried out by using PCD and K10 tools. Increasing of volume fraction in the matrix resulted in a decrease of the surface roughness and turning forces. PCD cutting tools showed better cutting performance than K10 tools.

Assessment of Proportion of Hidden Patients Having Symptoms of Overactive Bladder and Why Has It Been Hidden in Female Outpatients Admitted to Hospital

Oktay Üçer,Ömer Demir,Mehmet Fatih Zeren,Yasin Ceylan,İlker Çelen,Ali Ersin Zümrütbaş,Gökhan Temeltaş,Ozan Bozkurt,Bülent Günlüsoy,Orçun Çelik,Gökhan Ekin,Oğuz Mertoğlu,Aegean Study Group of Society o 대한배뇨장애요실금학회 2016 International Neurourology Journal Vol.20 No.1

Purpose: To determine the proportion of patients with undetected symptoms of overactive bladder by using the overactive bladder-validated 8 (OAB-V8) screening questionnaire and investigate these symptoms were undetected in female patients who were hospitalized. Methods: We invited 2,250 female patients hospitalized in the Aegean region of Turkey to answer a self-administered questionnaire. The questionnaire included questions on evidence of lower urinary tract symptoms (OAB-V8), relevant medical history, and demographic data. Patients with a total OAB-V8 score≥8 were defined as having OAB symptoms. Results: The proportion of patients with OAB symptoms in this study was 40.6%. Nearly 57% of the patients with OAB symptoms had not been previously admitted to any hospital for lower urinary tract symptoms (LUTS). The two most common reasons why women with OAB symptoms did not admit themselves to a hospital because of LUTS were as follows: “I did not think I had a disease” and “The symptoms did not bother me,” with a response rate of 74.7%. The mean OAB-V8 scores of the patients with these two responses were significantly lower than those of the other patients (P<0.001). Conclusions: This is the first study to demonstrate a significant proportion of women with undetected OAB symptoms. The main reasons the women did not admit themselves to a hospital were their unawareness of the disease and because the LUTS were not bothersome. Public awareness programs on this disease may resolve this problem.

COMPARISON OF REPAIR INTEGRITY AND FUNCTIONAL OUTCOMES BETWEEN KNOT-TYING AND KNOTLESS SUTURE-BRIDGE ARTHROSCOPIC ROTATOR CUFF REPAIR: A PROSPECTIVE RANDOMIZED CLINICAL TRIAL

Koray Sahin,Fatih Senturk,Mehmet Ersin,Mechmet Chodza,Ufuk Arzu,Ali Ersen 대한견주관절의학회 2021 대한견주관절학회 학술대회논문집 Vol.2021 No.3

Introduction and Background Suture-bridge (SB) rotator cuff repair (RCR) is widely used due to its superior biomechanical and clinical outcomes. However, knot-tying SB technique has been suspected to compromise the tendinous biology and to cause strangulation and medial repair failures. Therefore, knotless SB technique has been proposed to decrease retear rates. The purpose of this study is to compare clinical, structural outcomes and retear patterns between two techniques Material and Method 104 patients with full-thickness rotator cuff tear were randomly and prospectively allocated to knot-tying (group I) or knotless (group II) SB surgeries. Clinical outcome measures included range of motion values, subjective pain scores (VAS) and functional scores (Constant score). Repair integrity was evaluated with magnetic resonance imagings using Sugaya classification. Retears were also classified according to their patterns as type 1 (lateral) and type 2 (medial). 88 patients completed the follow-up period and were included to final analysis. Results Mean age of patients was 54.3 years in group I and 55.8 years in group II. Mean follow-up period was 25.4 and 23.3 months respectively. Mean pain score of group I decreased from 7.4 to 1.0 (p<0.0001). The corresponding values for group II decreased from 7.1 to 1.3 (p<0.0001). In group I, mean Constant score increased from 51.7 to 86.0 (p<0.0001) and in group II, mean Constant score increased from 49.4 to 87.2 (p<0.0001). There was not statistically significant difference between two groups regarding post-operative pain and functional scores (p>0.05). Post-operative MR imaging revealed that the retear rate was 19.0% (8/42) in group I and 28.3% (13/46) in group II (p>0.05). Type 2 failure rate was 75.0% (6/8) in group I and 23.1% (3/13) in group II (p=0.03). Conclusions Both techniques showed excellent improvement and comparable clinical outcomes. However, there was no significant difference in retear rates between techniques. Type 2 failure rate was higher in knot-tying technique.

Correlation between SERT polymorphisms and Venlafaxine response in major depression patients

Nevzat Yuksel,Ozlem Dogan,Mehmet Ali Ergun,Hatice Ersin Karslioglu,Aysegul Koc,Akin Yilmaz,Mustafa N. Ilhan,Adnan Menevse 한국유전학회 2010 Genes & Genomics Vol.32 No.3

Major depression (MD) has a complex multifactorial aetiology with genetic and environmental factors contributing to this disorder. As with all antidepressant treatments, there is variability in drug response because of heredity, and this leads us to focus on the genetic polymorphism of the drug's metabolising transporter genes. The serotonin transporter (5-HTT) gene is a particularly important candidate for genetic involvement in MD disorders owing to its key role in the regulation of serotonergic transmission and is therefore considered an interesting candidate in the mechanism of antidepressant drugs. Here, we studied the associations between genetic polymorphisms in two regions of the 5-HTT gene (5-HTTLPR and VNTR) to understand venlafaxine response. Venlafaxine was found to be effective in MD patients based on their HAM-D and CGI scores (p<0.05). Although the results did not yield a significant difference between the frequencies of the SS, LS,LL, 9/9, 10/10, 12/12 and 10/12 genotypes and venlafaxine response, venlafaxine dose was increased in patients with Stin2.12 and S alleles. These alleles might have a predisposition to mood disorders. Further studies with more patients are required to confirm this clinical association.

Anticancer Effects of Thymoquinone, Caffeic Acid Phenethyl Ester and Resveratrol on A549 Non-small Cell Lung Cancer Cells Exposed to Benzo(a)pyrene

Ulasli, Sevinc Sarinc,Celik, Sefa,Gunay, Ersin,Ozdemir, Mehmet,Hazman, Omer,Ozyurek, Arzu,Koyuncu, Tulay,Unlu, Mehmet Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

Background: Phytochemical compounds are emerging as a new generation of anticancer agents with limited toxicity in cancer patients. The purpose of this study was to investigate the potential effcts of thymoquinone, caffeic acid phenylester (CAPE) and resveratrol on inflammatory markers, oxidative stress parameters, mRNA expression levels of proteins and survival of lung cancer cells in Vitro. Materials and Methods: The A549 cell line was treated with benzo(a)pyrene, benzo(a)pyrene plus caffeic acid phenylester (CAPE), benzo(a)pyrene plus resveratrol (RES), and benzo(a)pyrene plus thymoquinone (TQ). Inflammatory markers, oxidative stress parameters, mRNA expression levels of apoptotic and anti-apoptotic proteins and cell viability were assessed and results were compared among study groups. Results: TQ treatment up-regulated Bax and down-regulated Bcl2 proteins and increased the Bax/Bcl2 ratio. CAPE and TQ also up-regulated Bax expression. RES and TQ down-regulated the expression of Bcl-2. All three agents decreased the expression of cyclin D and increased the expression of p21. However, the most significant up-regulation of p21 expression was observed in TQ treated cells. CAPE, RES and TQ up-regulated TRAIL receptor 1 and 2 expression. RES and TQ down-regulated the expression of NF-kappa B and IKK1. Viability of CAPE, RES and TQ treated cells was found to be significantly decreased when compared with the control group (p=0.004). Conclusions: Our results revealed up-regulation of the key upstream signaling factors, which ultimately cause increase in their regulatory p53 levels affecting the induction of G2/M cell cycle arrest and apoptosis. Overall these results provide mechanistic insights for understanding the molecular basis and utility of the anti-tumor activity of TQ, RES and CAPE.

Can feeling of incomplete bladder emptying reflect significant postvoid residual urine? Is it reliable as a symptom solely?

Yusuf Özlülerden,Cihan Toktaş,Ali Ersin Zümrütbaş,Mehmet Caner Gülten,Aykut Başer,Onur Yapıcı,Zafer Aybek 대한비뇨의학회 2018 Investigative and Clinical Urology Vol.59 No.1

Purpose: The main objective of this study was to reveal the relationship between lower urinary tract symptoms (LUTS) and post-void residual (PVR) urine volume. Materials and Methods: Between October 2014 and February 2015, older than 40 years patients were included in this study. Volunteers filled out a questionnaire consisted of demographic characteristics, comorbidities, medications, history of surgery and LUTS. Volunteers were undergone PVR measurement with transabdominal ultrasonography. The relationship between symptoms, demographic characteristics and PVR were analyzed. Results: A total of 939 patients (756 men and 183 women) were enrolled in this study. There was a positive correlation between the sensation of incomplete bladder emptying and PVR volume in all age groups of women (p=0.0001). However such a relationship was found only over the age of 60 in the subgroup analysis of men (p=0.001). PVR volume increased in men by age (0.65 mL per year of age, p=0.011). In men, voiding symptoms and urgency were associated with a high PVR volume. In women, storage and voiding symptoms (except slow stream and terminal dribble) did not correlate with PVR volume. Conclusions: Our study showed that all men over the age of 60 years and all women with the complaint of feeling of incomplete emptying should undergone PVR measurement. Women with the complaint of poor stream and men mainly with voiding symptoms are other candidates in whom PVR measurement would be considered as an important tool in the clinical management and follow-up.

Prevalence of Daytime Urinary Incontinence and Related Risk Factors in Primary School Children in Turkey

Deniz Bolat,Ismail Cenk Acar,Ali Ersin Zumrutbas,Saadettin Eskicorapci,Eyup Burak Sancak,Mehmet Zencir,Tahir Turan,Zafer Sinik 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.3

Purpose: Urinary incontinence is one of the major urinary symptoms in children andadolescents and can lead to major distress for the affected children and their parents. In accordance with the definitions of the Standardization Committee of theInternational Children’s Continence Society, daytime urinary incontinence (DUI) isuncontrollable leakage of urine during the day. The aim of this cross-sectional studywas to investigate the prevalence and associated risk factors of DUI in Turkish primaryschool children. Materials and Methods: The questionnaire, which covered sociodemographic variablesand the voiding habits of the children, was completed by the parents of 2,353 childrenwho were attending primary school in Denizli, a developing city of Turkey. The children’svoiding habits were evaluated by use of the Dysfunctional Voiding andIncontinence Symptoms Score, which is a validated questionnaire. Children with a historyof neurological or urological diseases were excluded. Results: The participation rate was 91.9% (2,164 people). The overall prevalence of DUIwas 8.0%. The incidence of DUI tended to decrease with increasing age and was notsignificantly different between genders (boys, 8.8%; girls, 7.3%; p=0.062). Age, maternaleducation level, family history of daytime wetting, settlement (urban/rural), historyof constipation, urinary tract infection, and urgency were independent risk factors ofDUI. Conclusions: Our findings showed that DUI is a common health problem in primaryschool children. In an effort to increase awareness of children’s voiding problems andthe risk factors for urinary dysfunction in the population, educational programs andlarger school-based screening should be carried out, especially in regions with low socioeconomic status.