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- 저자 : ( Mariel Dianne S. Velasco ) (검색결과 1 건)
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( Aubrey Q. Taguba ),( Mariel Dianne S. Velasco ),( Mara Teresa T. Panlilio ),( Maria Joanne M. Rubio ),( Margaret Elaine J. Villamayor ),( Janus P. Ong ),( Ma. Lourdes O. Daez ) 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: Low vitamin D levels result in higher incidence of liver fibrosis and cirrhosis, poor treatment response, and increased morbidity and mortality in patients with chronic liver disease (CLD). This study assessed whether CLD patients in the Philippines, despite adequate sunlight exposure, have vitamin D deficiency and whether this is associated with poor outcomes. Methods: Consecutive CLD patients at the outpatient clinics of PGH were included. Clinical data such as age, gender, body mass index, etiology of CLD, presence of cirrhosis and ascites, and number of hours of sun exposure daily were recorded. Standard biochemical liver tests within 3 months of enrolment into the study, such as alanine and aspartate aminotransferases, prothrombin time, total bilirubin, and albumin were documented. Child Pugh scores for cirrhotic patients were computed. Serum vitamin D was determined using the ARCHITECT chemiluminescent microparticle assay. STATA SE version12 for Windows was used for statistical analyses. Univariate analysis and simple logistic regression were used to determine independent predictors of vitamin D deficiency. A p-value of<0.05 was considered as statistically significant. Results: A total of 72 patients were included. The prevalence of vitamin D deficiency (<20ng/mL) was 6.9%; insufficiency (20.1 to 29ng.mL) 52.8%; and sufficiency (>30ng/mL) 40.3%. Both univariate analysis and logistic regression showed no statistical difference among vitamin D deficient, insufficient, and sufficient subjects in terms of etiology and factors affecting the severity of CLD. Conclusions: Vitamin D deficiency and insufficiency are prevalent in Filipino CLD subjects. Guidance on adequate sunlight exposure and dietary intake should be part of health maintenance intervention for these patients.
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