http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : ( Maitree Suttajit ) (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Anticancer Activity and Tumor Promoting Properties of Thai Medicinal Plants
Suttajit, Maitree 한국균학회 1987 韓國菌學會誌 Vol.15 No.3
The lecture will contain two parts: the anticancer activity study and the explanation of tumor promoting compounds in our medicinal plants. 1. Several medicinal herbs have been practically used as a folkloric remedy for cancer patients by our traditional village doctors. The plants have been claimed to be effective against different types fo tumors. However, scientific background and intensive biochemical investigation on their treatment effectiveness and chemistry of the active ingredients are still much lacking. We have been exploring the screening assay of anticancer activity of a number of Thai medicinal plants by in vitro cytotoxicity test on cultured cancer cells. The plants are graded by the percent inhibition of the cellular growth. After consideration of the possibility of effectiveness, a folkloric remedy formula was chosen and brought for the study. The anticancer effectiveness was determined on both the in vitro cultured cells and in vivo experimental rats. Combined aqueous extract from five traditional herbs medicinal herbs containing Polygala chinensis, Linn., Ludwigia hyssofolia(C.Don) Ewell, Climacanthus Siamensis Brem, Canna indica Linn. and Smilax corbularia Kunth C., exhibited some cytotoxic effect on KB cells in vitro and showed significant antitumor activity in malignant tumor bearing rats. The chemical components of the extracts will be discussed. 2. Various tumor promoters are present in our environment. Plants are one of the abundant source of tumor promoting compounds. These have been shown to cause rapid growth of cancer cells in the second step of carcinogenesis in experimental rats. To prevent the epidemiological occurrence of cancer, it is necessary to determine whether our plants contain hazardous tumor promoters. Many species in Euphorbiaceae family have phobol esters which are potent tumor promoters. An example of such plants will be brought up, Jatropha curcas Linn. The seed oil of Jatropha curcas exhibited skin tumor induction when applied with 7.12-dimethylbenz(a)anthracene by using the irritant test on mouse ear to detect the activity, the active fraction was partially purified from the methanol extract of the seed oil by column chromatography on Florisil and Sephadex LH-20. The obtained fraction induced ornithin decarboxylase in mouse skin and inhibited the specific binding of H-12-O-tetradecanoyl-phorbol-l3-acetate to a particulate fraction of mouse skin. After repeated applications, the active fraction could induce skin tumors fo 36% of the mice tested in 30 weeks. Tumor incidences in the groups treated with DMBA carcinogen alone and the active fraction alone were only 7% and 13% in the 30th week. The chemical structure of the active tumor promoting substance in the seed oil is now being studied. Anti-tumor promoters in the nature are of great interest as well.
-
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
