http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Woo, Jong Kyu,Kang, Ju-Hee,Shin, DongYun,Park, Seong-Hyeok,Kang, Kyungsu,Nho, Chu Won,Seong, Je Kyung,Lee, Sang-Jin,Oh, Seung Hyun American Association for Cancer Research 2015 Molecular Cancer Therapeutics Vol.14 No.7
<P>The aurora kinases constitute one family of serine/threonine kinases whose activity is essential for mitotic progression. The aurora kinases are frequently upregulated in human cancers and are associated with sensitivity to chemotherapy in certain ones. In the present study, we investigated whether aurora kinases could be a target to overcome radioresistance or enhance the radiosensitivity of lung cancer. For that purpose, we determined the therapeutic potential of daurinol, an investigational topoisomerase inhibitor, alone and in combination with radiation, by observing its effect on aurora kinases. Daurinol decreased cell viability and proliferation in human colon and lung cancer cells. Gene expression in daurinol-treated human colon cancer cells was evaluated using RNA microarray. The mRNA expression of 18 genes involved in the mitotic spindle check point, including aurora kinase A (AURKA) and aurora kinase B (AURKB), was decreased in daurinol-treated human colon cancer cells as compared with vehicle-treated cells. As expected, radiation increased expression levels of AURKA and AURKB. This increase was effectively attenuated by siRNAs against AURKA and AURKB, which suppressed cell growth and increased apoptosis under radiation. Furthermore, the expression of AURKA and AURKB was suppressed by daurinol in the presence or absence of radiation in colon and lung cancer cells. Daurinol alone or in combination with radiation decreased lung cancer growth in xenograft mouse models. Our data clearly confirm the antitumor and radiosensitizing activity of daurinol in human lung cancer cells through the inhibition of AURKA and AURKB. <I>Mol Cancer Ther; 14(7); 1693–704. ©2015 AACR</I>.</P>
Beneficial Effects of Cynaroside on Cisplatin-Induced Kidney Injury In Vitro and In Vivo
Nho, Jong-Hyun,Jung, Ho-Kyung,Lee, Mu-Jin,Jang, Ji-Hun,Sim, Mi-Ok,Jeong, Da-Eun,Cho, Hyun-Woo,Kim, Jong-Choon Korean Society of ToxicologyKorea Environmental Mu 2018 Toxicological Research Vol.34 No.2
Anti-cancer drugs such as cisplatin and doxorubicin are effectively used more than radiotherapy. Cisplatin is a chemotherapeutic drug, used for treatment of various forms of cancer. However, it has side effects such as ototoxicity and nephrotoxicity. Cisplatin-induced nephrotoxicity increases tubular damage and renal dysfunction. Consequently, we investigated the beneficial effect of cynaroside on cisplatin-induced kidney injury using HK-2 cell (human proximal tubule cell line) and an animal model. Results indicated that $10{\mu}M$ cynaroside diminished cisplatin-induced apoptosis, mitochondrial dysfunction and caspase-3 activation, cisplatin-induced upregulation of caspase-3/MST-1 pathway decreased by treatment of cynaroside in HK-2 cells. To confirm the effect of cynaroside on cisplatin-induced kidney injury in vivo, we used cisplatin exposure animal model (20 mg/kg, balb/c mice, i.p., once a day for 3 days). Renal dysfunction, tubular damage and neutrophilia induced by cisplatin injection were decreased by cynaroside (10 mg/kg, i.p., once a day for 3 days). Results indicated that cynaroside decreased cisplatin-induced kidney injury in vitro and in vivo, and it could be used for improving cisplatin-induced side effects. However, further experiments are required regarding toxicity by high dose cynaroside and caspase-3/MST-1-linked signal transduction in the animal model.
유산소운동이 중년 비만여성의 대사적 수용기 자극에 따른 심혈관 반응에 미치는 영향
한우람(Woo-Ram Han),최현민(Hyun-Min Choi),노호성(Hosung Nho),김종경(Jong-Kyung Kim) 한국생활환경학회 2011 한국생활환경학회지 Vol.18 No.4
The purpose of this study was to investigate whether aerobic exercise training improves the muscle metaboreflex in obese women. Eight obese women were recruited in this study. Subjects performed 3 min static handgrip exercise and 2 min of post exercise muscular ischemia (PEMI) while heart rate (HR), stroke volume (SV), systolic blood pressure (SBP), and diastolic blood pressure (DBP) were measured followed by the calculation of cardiac output, mean arterial pressure (MAP), and total vascular conductance (TVC). All subjects completed 12 wk aerobic exercise training consisting of 3 times/wk and 40 min per session. Subjects walked/ran at the exercise intensity of 50% maximum heart rate on the treadmill. In order to maintain the target heart rate, the speed and grade were manipulated every two weeks. With aerobic exercise training, SBP, DBP and MAP were significantly decreased during static exercise, while TVC was significantly increased. Both SBP and MAP responses mediated by the muscle metaboreflex were significantly decreased. These results indicate that aerobic exercise training altered the strength of the muscle metaboreflex. Thus, regular aerobic exercise training may improve impaired peripheral vasoconstriction and exaggerated blood pressure response induced by the muscle metaboreflex in obese women.
Isolation and Expression of Hemolin in Bombyx mori
Kim, Kyung-a,Kang, Min Uk,Kim, Nam Soon,Lee, Jin Sung,Kang, Seok Woo,Nho, Si-kab 한국유전학회 2005 Genes & Genomics Vol.27 No.1
Hemolin is a bacteria-induced immune protein found in the lepidopteran insect species. We isolated 1357 bp hemolin cDNA from the mid-gut in the middle of the spinning stage in B. mori, that demonstrated a high degree of similarity with hemolins from 4 species, M. sexta, H. cuena, H. cecropia, and L dispar. Hemolin mRNA was detected only in a microorganism invasion. The expression was not influenced by the external environment or materials. The developmental profile of the level of hemolin mRNA was determined in the absence of bacterial challenge. Hemolin mRNA was expressed only in the mid-gut, not in hemocytes, fat body, silk glands and gonads. During the development of B. mori, hemolin mRNAs were not detected in the mid-gut until the spinning stage of the last instar larvae, however, dramatically increased beginning the spinning and gradually decreased through the pupal and adult stages. The results of the in situ hybridization were consistent with northern blot analysis. The major transcription site of hemolin is the columnar cells in the mid-gut. It is presumed that the function of hemolin is unique to the physiological process at the post-spinning stage.
Perioperative Pain Management in Total Hip Arthroplasty: Korean Hip Society Guidelines
( Byung Woo Min ),( Yeesuk Kim ),( Hong Man Cho ),( Kyung Soon Park ),( Pil Whan Yoon ),( Jae Hwi Nho ),( Sang Min Kim ),( Kyung Jae Lee ),( Kyong Ho Moon ) 대한고관절학회 2016 Hip and Pelvis Vol.28 No.1
Effective perioperative pain management techniques and accelerated rehabilitation programs can improve healthrelated quality of life and functional status of patients after total hip arthroplasty. Traditionally, postoperative analgesia following arthroplasty was provided by intravenous patient-controlled analgesia or epidural analgesia. Recently, peripheral nerve blockade has emerged alternative analgesic approach. Multimodal analgesia strategy combines analgesics with different mechanisms of action to improve pain management. Intraoperative periarticular injection of multimodal drugs is one of the most important procedures in perioperative pain control for total hip arthroplasty. The goal of this review article is to provide a concise overview of the principles of multimodal pain management regimens as a practical guide for the perioperative pain management for total hip arthroplasty.