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( Motohiko Hara ),( Hiromi Nakamura Thomas ),( Kuniyasu Takahashi ),( Hiroaki Nobuhara ),( Ikuo Murohashi ),( Sachiko Yoshioka ),( Akira Haketa ),( Takahiro Ueno ),( Masayoshi Soma ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: We studied changes of physical strength, serum adiponectin and serum lipids in the same elder individuals for 5-years. Methods: We examined 156 volunteers (37 males and 119 females, mean age: 71. 5 years) in Ogano- town, Saitama, Japan. All subjects were examined in a battery of physical strength tests and serum laboratory examinations including BMI, blood pressure (BP), grip strength (GS), 10m walking time (10m WT), timed up and go test (TUG) and serum examinations consisting of HDL-cholesterol (HDL), triglyceride (TG) and adiponectin. All subjects were re-tested the battery of tests 5 years later. Results: In the 5-years, the significant changes from the baseline showed in the mean values of GS, TUG and serum adiponectin (males:6. 5μg/ml to 4. 8μg/ml, females: 8. 8μg/ml to 6. 7μg/ml) (p<0. 05, paired-t test). We divided the subjects into 3 groups by serum adiponectin levels; less than 4. 0μg/ml (19 males and 27 females), 4. 0 to 10. 0μg/ ml (14males and 72 females) and higher than 10. 0μg/ml (4 males and 20 females), and compared each groups. In the group of low adiponectin level, mean values of TG (males: 191. 7mg/dl, females: 176. 9mg/dl) was signifi cant higher than that of normal adiponectin level group (TG: males:116. 9mg/dl, females:138. 2mg/dl) and high adiponectin level group (TG: males: 102. 6mg/dl, females: 102. 7mg/dl), and mean values of HDL (males: 48. 5mg/ dl, females: 53. 0mg/dl) was signifi cant lower than that of normal adiponectin level group (HDL: males: 56. 8mg/dl, females: 58. 1mg/dl) and high adiponectin level group (HDL: males: 64. 3mg/dl, females: 70. 0mg/dl) in both of males and females. Conclusions: In elderly, 5-year changes are clear in physical tests. Serum adiponectin level showed decreasing for 5-years in males and females, and low serum adiponectin value has some relation with serum high TG and low HDL.