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- 저자 : ( Keshavarao Sasikala ) (검색결과 1 건)
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( Vellingiri Balachandar ),( Subramaniam Mohana Devi ),( Meyyazhagan Arun ),( S Haripriya ),( Iyer Mahalakshmi ),( Sn Dharwadkar ),( Keshavarao Sasikala ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Hepatocellular carcinoma (HCC) ids one of the most common cancer worldwide. Polymorphism in p53 and XRCC1 genes were associated with increased risk of early-onset HCC. We thus hypothesized that, these polymorphism could be more likely in South Indian population. However the status of these mutations in South Indian HCC had not been studied. Methods: In the present study 130 HCC patients and 130 control subjects were analyzed for known polymorphisms in the p53 and XRCC1 genes. Results: In the Arg194Trp polymorphism of p53 gene, we found 19.05% with Arg- 399Trp (heterozygous variant) genotype and 1.6% with 399Trp (homozygous variant) in comparison to controls who exhibited 90.39% with wild type genotype. In Arg399Gln polymorphism of XRCC1 gene, 46.17% were found to have Arg399Gln (heterozygous variant) genotype and 10.11% were found to have 399Gln (homozygous variant) genotype in comparison to controls who exhibited 55% individuals with heterozygous variant genotype and 16.75% with homozygous variant genotype. This polymorphic incidence revealed signifi cant association with advanced stages of the HCC and also well differentiated tumor. Conclusions: Thus the results of our study provide the genetic variations of p53 and XRCC1 which may contribute to the susceptibility to HCC in South India. The results suggest that, these genes could play a signifi cant role in HCC and the combined effect of these variants may interact to increase the risk of HCC in Indian population.
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