http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Jung Wan Choe ),( Seung Young Kim ),( Jong Jin Hyun ),( Sung Woo Jung ),( Young Kul Jung ),( Ja Seol Koo ),( Hyung Joon Yim ),( Sang Woo Lee ) 대한간학회 2017 Gut and Liver Vol.11 No.6
Background/Aims: Various clinical scoring systems, including the Glasgow-Blatchford score (GBS), Rockall risk score (RS), and AIMS65 score (AIMS65), have been validated to predict the clinical outcomes in patients with upper gastrointestinal bleeding (UGIB). We compared the performance of these three scoring systems in predicting clinical outcomes in patients with UGIB in Korea. Methods: We retrospectively evaluated 286 patients with UGIB who visited emergency department. The primary outcome was the need for clinical intervention (endoscopic, radiologic, or surgical) and blood transfusion. Results: The causes of UGIB were esophageal/gastric varices in 64 patients, peptic ulcer in 168, Mallory-Weiss tear in 32, malignancy of UGI tract in eight, and unknown in 14. One hundred seventy-four (61%) patients required blood transfusion, 166 (58%) required endoscopic intervention, and 10 (3.5%) required surgical intervention. The GBS outperformed the RS and AIMS65 in predicting the need for endoscopic intervention. Conclusions: The GBS and RS were more accurate than AIMS65 in predicting the need for clinical interventions and transfusion patients with UGIB, regardless of variceal or nonvariceal bleeding. The AIMS65 may not be optimal for predicting clinical outcomes of UGIB in Korea. (Gut Liver 2017;11:813-820)
Purification and Characterization of a Thermostable Xylanase from Fomitopsis pinicola
( Jung Kul Lee ),( Yeong Suk Kim ),( Shin Keum ),( Marimuthu Jeya ) 한국미생물 · 생명공학회 2010 Journal of microbiology and biotechnology Vol.20 No.10
An extracellular xylanase was purified to homogeneity by sequential chromatography of Fomitopsis pinicola culture supernatants on a DEAE-Sepharose column, a gel filtration column, and then on a MonoQ column with fast protein liquid chromatography. The relative molecular mass of the F. pinicola xylanase was determined to be 58 kDa by sodium dodecyl sulfate polyacrylamide gel electrophoresis and by size-exclusion chromatography, indicating that the enzyme is a monomer. The hydrolytic activity of the xylanase had a pH optimum of 4.5 and a temperature optimum of 70oC. The enzyme showed a t1/2 value of 33 h at 70oC and catalytic efficiency (kcat=77.4 s-1, kcat/Km=22.7 mg/ml/s) for oatspelt xylan. Its internal amino acid sequences showed a significant homology with hydrolases from glycoside hydrolase (GH) family 10, indicating that the F. pinicola xylanase is a member of GH family 10.
Lee, Young-Sun,Kim, Hyun Jung,Kim, Ji Hoon,Yoo, Yang Jae,Kim, Tae Suk,Kang, Seong Hee,Suh, Sang Jun,Joo, Moon Kyung,Jung, Young Kul,Lee, Beom Jae,Seo, Yeon Seok,Yim, Hyung Joon,Yeon, Jong Eun,Kim, Jae RAVEN PRESS PUBLISHERS 2017 JOURNAL OF CLINICAL GASTROENTEROLOGY Vol.51 No.4
<P>Background and Aims: Although both corticosteroids and pentoxifylline are currently recommended drugs for the treatment of patients with severe alcoholic hepatitis, their effectiveness in reducing mortality remains unclear. In this systematic review, we aimed to evaluate the therapeutic and adverse effects of corticosteroids, pentoxifylline, and combination by using Cochrane methodology and therefore determine optimal treatment for severe alcoholic hepatitis. Methods: We searched MEDLINE, EMBASE, and the Cochrane Central Register of Controlled Trials from their inauguration until October 2015. Combinations of the following keywords and controlled vocabularies were searched: alcoholic hepatitis, corticosteroid, and pentoxifylline. Results: A total of 2639 patients from 25 studies were included. The treatment groups did not differ significantly in terms of overall mortality. Analysis of 1-month mortality revealed corticosteroid monotherapy reduced mortality compared with placebo (OR= 0.58; 95% CI, 0.34-0.98; P= 0.04), but pentoxifylline monotherapy did not. The mortality with dual therapy was similar to corticosteroid monotherapy (OR=0.91; 95% CI, 0.62-1.34; P= 0.63). However, dual therapy decreased the incidences of hepatorenal syndrome or acute kidney injury (OR= 0.47; 95% CI, 0.26-0.86; P= 0.01) and the infection risk (OR= 0.63; 95% CI, 0.41-0.97; P= 0.04) significantly more than corticosteroid monotherapy did. None of the treatments conferred any medium-term or long-term survival benefits in the present study. Conclusions: Dual therapy was not inferior to corticosteroid monotherapy and could reduce the incidence of hepatorenal syndrome or acute kidney injury and risk of infection. Therefore, dual therapy might be considered in treatment of patients with severe alcoholic hepatitis.</P>
( Jung Wan Choe ),( Hyung Joon Yim ),( Seung Hwa Lee ),( Hwan Hoon Chung ),( Sang Jun Suh ),( Seung Young Kim ),( Jong Jin Hyun ),( Sung Woo Jung ),( Young Kul Jung ),( Ja Seol Koo ),( Ji Hoon Kim ),( 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aims: No single effective method has yet been established for the prophylactic treatment of gastric varices. So, we aimed to compare two prophylactic treatment methods, including EVO and BRTO for gastric varices. Methods: We retrospectively analyzed patients with gastric varices, who had undergone either EVO or BRTO as a prophylactic treatment. The end points were eradication rate of gastric varices and gastric variceal bleeding rate during the follow-up period. Results: Total 84 patients were consisted of 55 patients in EVO group and 29 patients in BRTO group. No difference was observed in the clinical profiles of patients, including age, gender, Child-Pugh score, etiology of liver cirrhosis, and presence of hepatocellular carcinoma, between the EVO and BRTO groups. There was also no difference with respect to endoscopic features of gastric varices including F-component and location. As primary end points, the gastric varices were disappeared partially or completely in 50 patients in EVO group, and 27 patients in BRTO group. (90.9% vs 93.1%, p= 0.542). At the complete eradication rate, there was also no difference between two groups. (49.1% vs 65.5%, p=-0.150) However, 12 patients in EVO group bled from gastric varices after treatment during the median follow-up of 28 months, compared to only one case in BRTO group. (21.8% vs 3.4%, p=0.027) In addition, there were no differences in worsening in the endoscopic classification of esophageal varices or amounts of ascites. All-cause mortalities were similar in both. Conclusions: EVO and BRTO are equally effective for eradication of gastric varices with similar frequencies of complications and mortalities. However, BRTO proved more effective in preventing bleeding from gastric varices in the long run.