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Alteration in Claudin-4 Contributes to Airway Inflammation and Responsiveness in Asthma
Lee, Pureun-Haneul,Kim, Byeong-Gon,Lee, Sun-Hye,Lee, June-Hyuck,Park, Sung-Woo,Kim, Do-Jin,Park, Choon-Sik,Leikauf, George D.,Jang, An-Soo The Korean Academy of Asthma, Allergy and Clinical 2018 Allergy, Asthma & Immunology Research Vol.10 No.1
<P><B>Purpose</B></P><P>Claudin-4 has been reported to function as a paracellular sodium barrier and is one of the 3 major claudins expressed in lung alveolar epithelial cells. However, the possible role of claudin-4 in bronchial asthma has not yet been fully studied. In this study, we aimed to elucidate the role of claudin-4 in the pathogenesis of bronchial asthma.</P><P><B>Methods</B></P><P>We determined claudin-4 levels in blood from asthmatic patients. Moreover, using mice sensitized and challenged with OVA, as well as sensitized and challenged with saline, we investigated whether claudin-4 is involved in the pathogenesis of bronchial asthma. Der p1 induced the inflammatory cytokines in NHBE cells.</P><P><B>Results</B></P><P>We found that claudin-4 in blood from asthmatic patients was increased compared with that from healthy control subjects. Plasma claudin-4 levels were significantly higher in exacerbated patients than in control patients with bronchial asthma. The plasma claudin-4 level was correlated with eosinophils, total IgE, FEV1% pred, and FEV1/FVC. Moreover, lung tissues from the OVA-OVA mice showed significant increases in transcripts and proteins of claudin-4 as well as in TJ breaks and the densities of claudin-4 staining. When claudin-4 was knocked down by transfecting its siRNA, inflammatory cytokine expressions, which were induced by Der p1 treatment, were significantly increased.</P><P><B>Conclusions</B></P><P>These findings thus raise the possibility that regulation of lung epithelial barrier proteins may constitute a therapeutic approach for asthma.</P>
( Pureun-haneul Lee ),( An-soo Jang ),( Byeong-gon Kim ),( Jisu Hong ),( Yun-ki Lee ),( June-hyuck Lee ),( Sung- Woo Park ),( Do-jin Kim ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Background: Air pollutants induce or incite respiratory diseases such as asthma and COPD. Whether junctional proteins can contribute to development or exacerbations of airway diseases remain to be clarified. Objective: The aim of this study was to observe the effect of diesel exhaust particulates (DEP) on junctional proteins of both nose and lung in a mouse model. Methods: Mice were treatment with saline (Sham) and exposed to 100 μg/m3 DEPs 1 hour a day for 5 days a week for 4 weeks and 8 weeks in a closed-system chamber attached to a ultrasonic nebulizer. Airway hyperresponsiveness (AHR) was measured and bronchoalveolar lavage fluid, lung and nasal tissue were collected. The effects of DEP on junctional proteins such as claudin (CLND) 4, CLND 5, and CLND 17 were estimated using Western blot, immunohistochemical stain in nasal and lung tissue. Results: AHR and inflammatory cells in the airway were higher in DEP exposure group than in control group and were higher in 4 and 8 weeks group than in control group. The expression of CLND4, CLND 5, and CLND 17 in both lung and nasal tissue were significantly increased in DEP exposure group than in the control group. Conclusion: These results suggesting that air pollutants can change CLDNs and disintegrate cell barriers, causing to airway inflammation of both nose and lung.
장재영 ( Jae Young Jang ),이준성 ( June Sung Lee ),김형준 ( Hyung-joon Kim ),심재준 ( Jae-Jun Shim ),김지훈 ( Ji Hoon Kim ),김보현 ( Bo hyun Kim ),권준혁 ( Choon Hyuck Kwon ),이승덕 ( Seung Duk Lee ),이해원 ( Hae Won Lee ),김정훈 대한간암학회 2017 대한간암학회지 Vol.17 No.1
The General Rules for the Study of Primary Liver Cancer was published in June 2001 as the first edition. Since then, the 5th edition of the General Rules for the Study of Primary Liver Cancer was published by the 17th Committee of the Korean Liver Cancer Association based on the most recent data. The 5th edition of the General Rules for the Study of Primary Liver Cancer ranged over numerous topics such as anatomy, medical assessment of the patients, staging of hepatocellular carcinoma, description of the image findings, summary of hepatic resection, description of the surgical specimens, liver transplantation, reporting the pathological findings, pathological examinations of liver specimen, non-surgical treatment, radiotherapy, and assessment of tumor response after non-surgical treatment of hepatocellular carcinoma. The 5th General Rules for the Study of Primary Liver Cancer will not only become the basis of academic development for liver cancer studies in Korea, but also serve as the primary form of national liver cancer data accumulation based on standardized rules. (J Liver Cancer 2017;17:19-44)
P213 Differences in sites dermoscopic findings of Riehl`s melanosis on the cheek and neck
( June Hyuck Yim ),( Hyung-jin Park ),( Hye-jin Ahn ),( Tae-in Kim ),( Min Kyung Shin ),( Mu-hyoung Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
<div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div><div style="display:none">fiogf49gjkf0d</div> Background: The diagnosis of Riehl’s melanosis is difficult because diagnostic criteria have not been clearly established. A recent study suggested that pseudonetwork and grey dots/granules were the most suggestive dermoscopic features of Riehl’s melanosis on the face. However, Riehl’s melanosis can also occur on the neck. Dermoscopic features of Riehl’s melanosis at this site have not been reported. Objectives: The aim of our study was to compare dermoscopic findings of the face and neck in patients with Riehl’s melanosis. Methods: Clinical charts and dermoscopic images of 7 patients with Riehl’s melanosis were retrospectively assessed. Results: In the dermoscopic images of the neck, in addition to pseudonetwork, grey dots/granules, telangiectatic vessels, slight scales and hypopigmented furrow patterns were observed in all patients. Conclusion: In this study, we were able to determine that pseudonetwork and grey dots/granules were the most suggestive dermoscopic features of Riehl’s melanosis. In the neck, we also observed a hypopigmented furrow pattern with slight scale. These findings may be helpful in the diagnosis of Riehl’s melanosis.
( June Hyuck Yim ),( Min Jae Gwak ),( Myong Il Bae ),( Boo Kyoung Kang ),( Ki Heon Jeong ),( Min Kyung Shin ),( Mu Hyoung Lee ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Confluent and reticulated papillomatosis (CRP) is an uncommon dermatosis that affects young individuals and presents with greyish papules that coalesce to form a peculiar reticulated pattern usually on the trunk. Histological findings show hyperkeratosis, papillomatosis and some acanthosis, resembling the histological pattern of acanthosis nigricans (AN). AN is clinically characterized by patches or plaques with a greyish papillomatous texture, typically localized on the neck and in intertriginous areas such as the axillae and groin. Objectives: The pathogenesis of CRP and AN is still unknown, CRP and AN are considered as two distinct pathologies and differentiated because of their distinctiveclinical features, but sometimes it is not easy to distinguish these two disease. Methods: Eleven subjects with initially ambiguous diagnosis of CRP or AN were included in our study. Some cases were hard to diagnose exactly, moreover, some cases were considered coexistence of two diseases, although two diseases show different clinical and histopathological findings. So we tried oral minocycline to patients for diagnostic therapy. Results: By the therapeutic response to minocycline, 4 cases were supposed to be as CRP concurrent with AN, 4 cases as CRP, and 3 cases as AN. Conclusion: In conclusion, we consider that the trial of oral minocycline helps to differentiate CRP from AN.
( June Hyuck Yim ),( Tae In Kim ),( In Jung Kang ),( Ki Heon Jeong ),( Su Kang Kim ),( Joo Ho Chung ),( Min Kyung Shin ),( Mu Hyoung Lee ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Numerous studies have investigated the potentialrelationship of human leukocyte antigen (HLA)-G 14bp insertion/deletion (INS/DEL) polymorphism with autoimmune disease (AID). However, results from published data were inconclusive. Objectives: Our aim in this study was to determine whether the 14bp INS/DEL polymorphism in the HLA-G gene contributes to the risk of AID. Methods: A systemic literature search of PubMed and Embase databases was conducted to identify eligible studies investigating the association of HLA-G 14bp INS/DEL polymorphism with AID. The final analysis included 13 publications with a total of 6462 individuals. Results: Overall, no significant association between HLA-G 14-bp INS/DEL polymorphism and overall AID was detected in all comparison models. Further subgroup analyses based on AID types and ethnicity showed no significant association. Conclusion: Our results suggest that the HLA-G 14bp INS/DEL polymorphism might not be related to the development of AID. Further studies with larger sample size are warranted to validate our finding.
( June Hyuck Yim ),( Hyung-jin Park ),( Hye-jin Ahn ),( Ki Heon Jeong ),( Min Kyung Shin ),( Mu-hyoung Lee ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Background: Treatment of atopic dermatitis (AD) and psoriasis requires their differentiation from other eczematoid dermatitis and a determination of disease severity. However, both can be clinically difficult and the findings subjectively interpreted. Objectives: We investigated the utility of in vivo autofluorescence (AF) measurements for diagnosis of both diseases, and determination of severity. Methods: 30 patients with AD and 30 with psoriasis were recruited, together with sex- and age-matched patients with healthy skin. AF intensity was measured using the EcoSkin® fluorescence video dermatoscope. In AD and psoriasis patients, AF in non-sun-exposed lesional and non-lesional skin was measured. To identify the locations that reflect characteristics of AD, AF was also measured at the other sites in the patients with AD. Results: AD was associated with lower AF and psoriasis with higher AF intensity peaking around 620 nm. In addition, skin AF intensity of each disease was associated with severity of lesion. Conclusion: Non-invasive measurement of skin AF in vivo can aid in diagnosis of AD and psoriasis as well as in treatment monitoring.