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장순자,김형중,여인권 강원대학교 석재복합신소재제품연구센터 2001 석재연 논문집 Vol.6 No.-
영상검색은 문자위주의 검색의 한계로, 그 내용에 기반 한 특징벡터를 이용하여 검색을 수행한다. 특징벡터간의 거리를 계산하고 그 값들에 순위를 매긴다. 이렇게 얻어진 순위 값들을 가지고 사용된 검색방법의 유효성을 검사하는데 Recall/Precision방법이 이용되고 있다. 질의영상과 같은 군에 속하는 영상이 얼마나 검출되었는지를 검출된 영상에 기반 하여 계산하거나, 영상 군에 기반 하여 계산하는 방법들이다. 그러나, 검출되는 순위 값의 범위를 정하고, 그 범위 내에 속하는 만족하는 값의 개수를 세는 방법을 이용한다. 따라서 주어진 두 샘플의 전체적인 경향을 비교하지는 못한다. 본 연구에서는 순위를 이용하여 비교하고자하는 두 샘플의 순위들을 결합하여 순위를 매기고 각 샘플들에 매겨진 순위값들의 평균과 분산을 이용하여 각 샘플들을 전체적으로 비교할 수 있다. Retrieval effectiveness of content-based image is usually measured by "recall and precision" method. The method has disadvantages such that it depends on the number of considered images among retrieved ones. We propose the Wilcoxon rank test for measuring retrieval effectiveness instead of the recall and precision.
Lovastatin의 암세포에 대한 항증식 효과에 관한 연구
이환봉,장정순 圓光大學校 醫科學硏究所 1999 圓光醫科學 Vol.15 No.1
Background: Lovastatin which is a potent inhibitor of HMG-CoA reductase has antiproliferative effect on cancer cells. We investigated the cell cycle regulatory mechanism of anti-proliferative effect of lovastatin and its therapeutic value on cancer treatment. Methods: MDA-MB-231, an ER negative breast cancer cell line and PC-3-M, an androgen independent prostate cancer cell line were grown up to use. We checked expression pattern of cell cycle regulatory proteins such as cyclins, cdk inhibitors including p21, cdks, RB and RB family protein p107 with lovastatin by Western blot analysis and immunoprecipitation. Results: The proliferative tendency of breast cancer and prostate cancer cells was decreased with 10 μM lovastatin. Cyclin D1 was decreased, however p21, a cdk inhibitor was increased with lovastatin. There is no change in the protein level of cyclin E, cdk4 and cdk2. After 36 h incubation with lovastatin, RB and p107 were dephosphorylated and showed increased binding with transcription factor E2F1 and E2F4 respectively. Conclusion: These results show that lovastatin has antiproliferative effects on breast and prostate cancer cells. The cell cycle regulatory effects of lovastatin come to G1 phase and those are mediated by cyclin D1 depression, p21 induction and decreased activity of cdk4. In accordance with them RB dephosphorylation and its sucessive binding with E2F1 seem to have important role in growth inhibitory effect of lovastatin. These data suggest that growth inhibitory activity of lovastatin by way of cell cycle regulation supports the therapeutic value for cancer treatment.
장정순(Joung Soon Jang),전재범(Jae Bum Jun),이오영(Oh Young Lee),유대현(Dae Hyun Yoo),김성윤(Seong Yoon Kim),주경빈(Kyung Bin Joo) 대한내과학회 1990 대한내과학회지 Vol.39 No.3
N/A Dry mouth is a commnon symptom in rheumatoid arthritis patients and an important component of sjoren's syndrome. The symptoms of dry mouth are very sultle difficult to assess. So, different procedures have been employed to assess, alivary gland function. One of them, parotid sialography, is a useful diagnostic procedure for sialadenitis. But this kind of investigation can cause pain, swallowing of the parotid gland, or exceptional allergic reaction to radiologic contrast media. In addition, it is a relatively complicated procedure to implement. On the other hand, despite the fact that the salivary gland can readily be evaluated by ultrasonography (US), there have been few reports describing the value of US in salivary gland diseases. We investigated the discriminative role of US versus parotid sialography in 31 patients with complaints of dry mouth and took minor salivary gland biopsies prospectively. All the patients in our study were women, and the age distribution was 28 to 66. The results were as follows: 1) In parotid sialography, 16 of the 20 patients with sialadenitis in minor salivary gland biopsy had abnormal findings over stage 2, and nine of the 11 without sigladenitis had normal findings (p=0.003). 2) In parotid US, 15 of the 20 patients with sialadenitis in minor salivary gland biopsy had decreased, namely abnormal, parotid gland echogenecity, and eighe of the 11 without sialadenitis had normal findings (p=0.028). 3) Comparing paratid US with parotid sialography, a good correlation between US parotid gland echogenecity and sialographic abnormalities was found. Ten of the 13 patients with abnormal US findings had abnormal sialograms, whereas three of the 15 with normal parotid gland echogenecity had abnormal sialo-grams (p=0.003). 4) No significant difference in submandibular echogenecity on US could be demonstrated. ESR tends to increase for patients with decreased parotid gland echogenecity (p=0.03). In summary, our study demonstrated that US, although not perfectly sensitive or specific, is a valuable noninvasive imaging techinque in screening for salivary gland involvement in patients with complants of dry mouth. Together with other studies it could be used as a first step in the diagnostic investigation of sialadenitis.
Joung, Yochan,Cha, Chang-Jun,Im, Wan-Taek,Jeon, Che Ok,Joh, Kiseong,Kim, Seung-Bum,Kim, Wonyong,Lee, Soon Dong,Cho, Jang-Cheon The National Institute of Biological Resources 2018 Journal of species research Vol.7 No.1
In 2016, as a part of the research program 'Survey of Korean Indigenous Species', diverse environmental samples were collected from various sources of freshwater, seawater, soil, wetland, reclaimed land, sand, pine forest, plant root, ginseng field, solar saltern, and caves. Thousands of bacterial strains were isolated from the diverse samples and identified based on 16S rRNA gene sequence analyses. The present study, as a phylogenetic subset of the primary research program, reports 24 unrecorded bacterial species in Korea that belong to the orders Rhizobiales and Sphingomonadales in the class Alphaproteobacteria. Based on the high 16S rRNA gene sequence similarities (>98.8%) and formation of a robust phylogenetic clade with the closest type species, it was determined that each strain belonged to each independent and predefined bacterial species. There is no official report that these 24 bacterial species have been described in Korea; therefore, 10 species of nine genera in the order Rhizobiales and 14 species of seven genera in the order Sphingomonadales are described for unreported alphaproteobacterial species in Korea. Gram reaction, colony and cell morphology, biochemical properties, and isolation sources are also provided in the species description section.
장순자,김형중,여인권 강원대학교 부설 석재복합신소재 제품연구센터 2000 석재연 논문집 Vol.5 No.-
이 연구는 내용 기반 석재 영상 검색을 위한 특징 벡터 추출방법을 제안한다. 영상 내 변화(위치변화, 크기변화)를 갖는 쌍 영상돌로 구성된 DB를 가지고 제아한 방법과 칼라 히스토그램방법을 비교하였다. JPEG 영상을 역허프만 코딩하여 얻는 DCT 계수벡터들의 일정 위치에서 얻어진 원소들로 특징벡터를 구성하였다. 이것은 복호화 과정의 일부만을 거치므로 빠르고, 계산량의 상당히 줄일 수 있고. 실험결과에서 보인 것처럼 칼라히스트그램 방법보다 영상 내 변화에 덜 민감하여 더 정확히 유사한 영상을 검색할 수 있다. A feature vector extraction method is proposed based on JPEG-compressed imgae data. This method is fast whenever the given images are JPEG-compressed since this method extracts feature vectors from the DCT coefficients rather than image itself. Simulation results show that this method is less sensitive to changes oof distance and position than color histogram method.