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      • Slide Session : OS-GAS-19 ; Gastroenterology : Acute Pancreatitis in Southern Israel-Alcohol is Over, New Culprits are Found

        ( Ilia Polishchuk ),( Ahmed Algedafi ),( Jorge Shmuel Delgado ),( Dov Gefel ),( Galina Novokhatko ),( Olga Grisko ),( Shirly Hever ),( Alice Hochberg ),( Eli Ben Valid ),( Mariana Zamir ),( Levi Doron 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1

        Background: Gallstones and alcohol are the most important worldwide etiologic causes of acute pancreatitis. In Israel, we lack critical information regarding the etiology of acute pancreatitis. Objectives: to delineate the prevalence, the main causes, rate of recurrence of acute pancreatitis in southern Israel. Methods: We performed a retrospective cohort study, including the review of all medical charts of hospitalized patients diagnosed with acute pancreatitis between the years 2000-12. Results: 600 patients with “acute pancreatitis” were recorded (1.4:1000 admissions). 42% of patients were admitted to the general surgery department, and 50.9% to internal medicine wards. The main causes for acute pancreatitis were cholelithiasis (41.5%), alcohol (8.8%) and drugs (8.3%). Disothiazide was the most common drug associated with pancreatitis followed by Sitagliptin, Angiotensin Converting Enzyme inhibitors and simvastatin. 33.6% of cases were of undetermined etiology. Recurrence was noted in 33.8% of patients (alcohol OR 3.7%, hypertrigliceridemia OR 1.8) with noimplications on mortality. Conclusions: Biliary pancreatitis is still the main cause of pancreatitis in Israel and is a much more common etiology than alcohol. Drug-induced pancreatitis is a common etiology, with Thiazide being the most common drug associated with pancreatitis followed by ACE-Inhibitors sitagliptin and simvastatin. Sitagliptin was found to be a significant cause for acute pancreatitis (OR 1:5). A third of the cases of acute pancreatitis are idiopathic. Recurrence appears at least in a third of the patients.

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