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RISS 인기검색어
- 검색키워드
- 저자 : ( Jihong You ) (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
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Kim, Seong Han,Yang, Seo Yeon,You, Jihong,Lee, Sang Bae,You, Jin,Chang, Yoon Soo,Kim, Hyung Jung,Ahn, Chul Min,Byun, Min Kwang,Park, Hye Jung,Park, Jung-Won The Korean Academy of Tuberculosis and Respiratory 2016 Tuberculosis and Respiratory Diseases Vol.79 No.4
Background: Specific immunoglobulin E (IgE) sensitization to staphylococcal enterotoxin (SE) has been recently considered to be related to allergic disease, including asthma. Despite studies on specific IgE (sIgE) to SE and its relationship to asthma diagnosis and severity, the association of sIgE to SE with airway hyperresponsiveness (AHR) remains unclear. Methods: We enrolled 81 asthma patients admitted to the Severance Hospital in Korea from March 1, 2013, to February 28, 2015 and retrospectively reviewed the electronic medical records of the enrolled subjects. The serum levels of sIgE to SE (A/B) of all subjects was measured using the ImmunoCAP 250 (Phadia) system with SE-sIgE positive defined as >0.10 kU/mL. Results: The SE-sIgE level was not significantly correlated with asthma severity (forced expiratory volume in 1 second [$FEV_1$], $FEV_1$/forced vital capacity, sputum eosinophils, and serum eosinophils), whereas the SE-sIgE level in patients with positive AHR ($mean{\pm}standard$ error of the mean, $0.606{\pm}0.273kU/mL$) was significantly higher than that in patients with negative AHR ($0.062{\pm}0.015kU/mL$, p=0.034). In regression analysis, SE sensitization (sIgE to SE ${\geq}0.010kU/mL$) was a significant risk factor for AHR, after adjustment for age, sex, $FEV_1$, and sputum eosinophils (odds ratio, 7.090; 95% confidence interval, 1.180-42.600; p=0.032). Prevalence of SE sensitization was higher in patients with allergic rhinitis and non-atopic asthma patients, as compared to patients without allergic rhinitis and atopic asthma patients, respectively, but without statistical significance. Conclusion: SE sensitization is significantly associated with AHR.
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( Seong Han Kim ),( Seo Yeon Yang ),( Jihong You ),( Sang Bae Lee ),( Jin You ),( Yoon Soo Chang ),( Hyung Jung Kim ),( Chul Min Ahn ),( Min Kwang Byun ),( Hye Jung Park ),( Jung-won Park ) 대한결핵 및 호흡기학회 2016 Tuberculosis and Respiratory Diseases Vol.79 No.4
Background: Specific immunoglobulin E (IgE) sensitization to staphylococcal enterotoxin (SE) has been recently considered to be related to allergic disease, including asthma. Despite studies on specific IgE (sIgE) to SE and its relationship to asthma diagnosis and severity, the association of sIgE to SE with airway hyperresponsiveness (AHR) remains unclear. Methods: We enrolled 81 asthma patients admitted to the Severance Hospital in Korea from March 1, 2013, to February 28, 2015 and retrospectively reviewed the electronic medical records of the enrolled subjects. The serum levels of sIgE to SE (A/ B) of all subjects was measured using the ImmunoCAP 250 (Phadia) system with SE-sIgE positive defined as >0.10 kU/mL. Results: The SE-sIgE level was not significantly correlated with asthma severity (forced expiratory volume in 1 second [FEV<sub>1</sub>], FEV<sub>1</sub>/forced vital capacity, sputum eosinophils, and serum eosinophils), whereas the SE-sIgE level in patients with positive AHR (mean±standard error of the mean, 0.606±0.273 kU/mL) was significantly higher than that in patients with negative AHR (0.062±0.015 kU/mL, p=0.034). In regression analysis, SE sensitization (sIgE to SE ≥0.010 kU/mL) was a significant risk factor for AHR, after adjustment for age, sex, FEV<sub>1</sub>, and sputum eosinophils (odds ratio, 7.090; 95% confidence interval, 1.180-42.600; p=0.032). Prevalence of SE sensitization was higher in patients with allergic rhinitis and non-atopic asthma patients, as compared to patients without allergic rhinitis and atopic asthma patients, respectively, but without statistical significance. Conclusion: SE sensitization is significantly associated with AHR.
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S-58 H. pylori infection is associated with subclinical coronary atherosclerosis in healthy subjects
( Minyoung Lee ),( Haeri Baek ),( Jong Suk Park ),( Sohee Kim ),( Chanhee Kyung ),( Sangbae Lee ),( Jihong You ),( Su Jung Baik ),( Byoung Kwon Lee ),( Jie-hyun Kim ),( Chul Woo Ahn ),( Kyung Rae Kim 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Background/Aims: Helicobacter pylori (H. pylori) is a gastrointestinal pathogen known to be associated with cardiovascular disease (CVD). However, most reports about the effect of H. pylori on CVD were investigated in patients with a previous history of CVD and little is known in healthy subjects. We evaluated the association between H. pylori infection and subclinical atherosclerosis using cardiac multidetector computed tomography (MDCT) in healthy subjects without CVD history. Methods: From December 2007 to February 2014, 471 subjects who underwent all of rapid urease test (CLO test), pulse-wave velocity (PWV) and MDCT for health check-up were enrolled. H. pylori infection was defined by CLO test positivity on endoscopic gastric biopsy. Significant coronary artery stenosis was defined as ≥50% stenosis in any major epicardial coronary vessel on MDCT. Results: The CLO-positive subjects had a lower high density lipoprotein-cholesterol (HDL-cholesterol) level than the CLO-negative subjects. Although there was no difference in the mean value of PWV, the incidence of significant coronary stenosis was higher in CLO-positive group (7.9% versus 2.9%, p=0.01). Also, the number of subjects with coronary artery calcium score>0 and Log{(Number of segments with plaque)+1} were slightly higher in CLO-positive group. CLO-positive group was 3-fold more likely to have significant coronary artery stenosis even after adjusting confounding factors (adjusted OR 3.081, 95% confidence interval 1.169-8.119, p=0.02). Conclusions: In a healthy population, current H. pylori infection was associated with significant subclinical coronary artery stenosis. The causal effect of H. pylori on subclinical atherosclerosis in a ‘healthy’ population remains to be investigated further.
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