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- 저자 : ( Jianjun Mu ) (검색결과 3 건)
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Rock burst risk in an island longwall coal face by stress field
Guangjian Liu,Zonglong Mu,Jianjun Chen,Jing Yang,Jinglong Cao 한국지질과학협의회 2018 Geosciences Journal Vol.22 No.4
In many coal mines in China, skip-mining and the corner coal pillar will lead to the formation of an island longwall coal face (ILCF), which will induce a series of problems. Rock bursts pose a severe threat to miners and safe production in coal mines. Here, we used a mechanical model, theoretical calculations, seismic computed tomography, and energy density to explore the stress field distribution in an ILCF to obtain some pre-warning parameters. Based on elastic thin-plate theory, three cases of rock strata of ILCF were analysed to explore various stress fields (case 1: solid coal, case 2: two-sided goaf, and case 3: four-sided goaf). The stress reaches the peak value at the points of “a = b” in case 1, “a = 0.7b” in case 2, and “a = 1.4b” in case 3, respectively, which indicates high rock burst risk. In the case study, the test methods of seismic computed tomography and energy density were used on four ILCFs in Zhaolou Coal Mine (ILCFs 11301, 1307, 1305, and 1306). The stress field can be reflected by the three parameters: velocity distribution, velocity gradient, and stress concentration factor; and the energy density can indirectly reflect the accumulated damage of coal and rock mass and test two parameters of velocity distribution and stress concentration factor, which verifies the stress field in ILCFs, and assesses their rock burst risk.
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Wang, Haixia,Shi, Xin,Cheng, Longlong,Han, Jie,Mu, Jianjun The Korean Society of Pharmacology 2021 The Korean Journal of Physiology & Pharmacology Vol.25 No.3
The present study explored the therapeutic potential of hydrogen sulfide (H2S) in restoring aging-induced loss of cardioprotective effect of remote ischemic preconditioning (RIPC) along with the involvement of signaling pathways. The left hind limb was subjected to four short cycles of ischemia and reperfusion (IR) in young and aged male rats to induce RIPC. The hearts were subjected to IR injury on the Langendorff apparatus after 24 h of RIPC. The measurement of lactate dehydrogenase, creatine kinase and cardiac troponin served to assess the myocardial injury. The levels of H2S, cystathionine β-synthase (CBS), cystathionine γ-lyase (CSE), nuclear factor erythroid 2-related factor 2 (Nrf2), and hypoxia-inducible factor (HIF-1α) were also measured. There was a decrease in cardioprotection in RIPC-subjected old rats in comparison to young rats along with a reduction in the myocardial levels of H2S, CBS, CSE, HIF-1α, and nuclear: cytoplasmic Nrf2 ratio. Supplementation with sodium hydrogen sulfide (NaHS, an H2S donor) and l-cysteine (H2S precursor) restored the cardioprotective actions of RIPC in old hearts. It increased the levels of H2S, HIF-1α, and Nrf2 ratio without affecting CBS and CSE. YC-1 (HIF-1α antagonist) abolished the effects of NaHS and l-cysteine in RIPC-subjected old rats by decreasing the Nrf2 ratio and HIF-1α levels, without altering H2S. The late phase of cardioprotection of RIPC involves an increase in the activity of H2S biosynthetic enzymes, which increases the levels of H2S to upregulate HIF-1α and Nrf2. H2S has the potential to restore aging-induced loss of cardioprotective effects of RIPC by upregulating HIF-1α/Nrf2 signaling.
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Combined Lowering Effects of Rosuvastatin and L. acidophilus on Cholesterol Levels in Rat
( Lijun Wang ),( Baihua Zhou ),( Xue Zhou ),( Yang Wang ),( Hongwei Wang ),( Shengying Jia ),( Zhipeng Zhang ),( Chao Chu ),( Jianjun Mu ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 Journal of microbiology and biotechnology Vol.29 No.3
Statins are a class of lipid-lowering drugs commonly used in the prevention of cardiovascular diseases. However, statin therapy presents many limitations, which have led to an increased interest in non-drug therapies, such as probiotics, to improve blood cholesterol levels. Indeed, probiotic strains such as Lactobacillus acidophilus have been found to improve blood lipid profiles, especially in reducing total cholesterol and LDL-C levels. In this study, we established a high-cholesterol rat model and studied the effect of Lactobacillus acidophilus administration alone or in combination with rosuvastatin. We were able to show that Lactobacillus exerts a cholesterol-lowering effect. Additionally, we observed that when administered together, rosuvastin and Lactobacillus exert a combined cholesterol-lowering effect. Altogether, our data advocate for the possibility of establishing probiotics as non-drug supplements for the treatment of hypercholesterolemia.
ScienceON
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