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- 저자 : ( Jei Hee Leeb ) (검색결과 1 건)
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( Hyo Jung Cho ),( Ji Sun Namc ),( Jae Keun Kim ),( Jei Hee Leeb ),( Bohyun Kim ),( Hee Jung Wang ),( Bong Wan Kim ),( Jung-dong Lee ),( Dae Yong Kang ),( Ji Hyun Kim ),( Yang Min Jae ),( Jae Chul Hwa 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1
Aim: We aimed to evaluate prognostic implication of circulating microRNA (miR)-21, 26a, and 29a in patients with hepatocellular carcinoma (HCC) who underwent hepatic resection or radiofrequency ablation (RFA) for curative treatment. Methods: A total of 120 patients with hepatitis B virus (HBV)-related HCC who underwent surgical resection (n=63) or RFA (n=57) were included. Expression levels of miR-21, 26a, and 29a in pretreatment plasma were assessed by fold change of Ct values acquired by quantitative real-time polymerase chain reaction. Several clinical variables and pretreatment circulating miRs were analyzed for identifying prognostic markers by using Kaplan-Meier analysis and Cox regression analysis. Results: Univariate analysis showed that age, low albumin level, low platelet count and advanced tumor stage (modified UICC stage III, IV), low miR-26a (Hazard ratio [HR]=1.72; 95% confidence interval [CI]=1.04-2.83; P=0.035) and low miR-29a (HR=1.75; 95% CI=1.04-2.94; P=0.035) were identified as independent risk factors of poor disease-free survival (DFS). In the analysis of liver transplantation (LT)-free survival, all of low miR-21, miR-26a and miR-29a were associated with poor LT-free survival in univariate analysis. However, multivariate Cox regression analysis revealed that low miR-26a (HR=3.41; 95% CI=1.32-8.82; P=0.011) and low miR-29a (HR=2.75; 95% CI=1.10-6.85; P=0.030), low platelet count and advanced tumor stage were significantly associated with poor LT-free survival. Circulating miR-21 was not significantly associated with both DFS and LT-free survival in multivariate analysis, even though miR-21 was positively correlated with tumor size and tumor stage. Correlation analysis showed remarkable correlation between circulating miR-26a and miR-29a (Spearman’s rho = 0.734, P<0.001). Conclusion: Pretreatment levels of circulating miR-26a and miR-29a were independent prognostic markers for predicting poor DFS and LT-free survival in patients with HBV-related HCC who underwent hepatic resection or RFA.
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