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- 저자 : ( Jayson Cagadas Pasaol ) (검색결과 1 건)
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( Jansen Marcos Cambia ),( Jin Kyoung Oh ),( Jayson Cagadas Pasaol ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Liver cancer (LC) is currently the sixth most common type of cancer with an increasing incidence in the Philippines. The study aimed to analyze time trends in LC incidence over the 10-year period. Herein, we provide model-based estimates of limited time LC cases by histological subtype from year 2003- 2012. Methods: Data for calculating LC incidence rates in 2003-2012 were obtained from the population-based Department of Health- Rizal Cancer Registry. Joinpoint regression was used to analyze trends and estimate annual percentage change (APC) with 95% confidence intervals (CI) on LC incidence by histological subtypes, time- period, sex, and calculated incidence counts, rates per 100,000 person-years. Results: LC incidence shows increasing average annual rates in the past 10 years, observed rates overall (10.94), men (15.53) and women (6.39). Among LC histological subtype in carcinoma, hepatocellular contribute highest rates, in men (15.19) and women (5.23), followed by unspecified carcinoma, in men (1.73) and women (0.78). Incidence trend declines in both sexes, and increases thereafter, in men in 2007 (APC: 16.82, 95% CI: -5.70; 44.80) and women in 2008 (APC: 19.95, 95% CI: -21.7; 83.7). The highest increase in average annual percentage change (AAPC) among LC histological subtype were observe to hepatoblastoma, in men (AAPC: 4.91, 95% CI: -8.90; 20.80) and women (AAPC: 16.33, 95% CI: -0.60; 34.50). Along with cholangiocarcinoma shows an increasing AAPC, in men (AAPC: 3.68, 95% CI: -7.90; 16.70) and women (AAPC: 0.15, 95% CI: -14.1; 16.7). Conclusions: The study revealed from 2003-2012, LC incidence trends by histological subtype were consistently increased. Among LC histological subtypes, an increase in incidence was observed in hepatocellular carcinoma for the past 10-year period. Targeted screening and treatment in hepatitis B virus (HBV) and hepatitis C virus (HCV), treatment of diabetes, and primary prevention of obesity, will be the possible solutions in reducing the increasing LC incidence.
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