http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
( Jae Hwan Kim ),( Jong Mi Lee ),( James G. Krueger ),( Chang Min Kim ),( Aeree Kim ),( Soo Hong Seo ),( Chil Hwan Oh ),( Il-hwan Kim ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Background: Acral Melanoma (AM) is a subtype of melanomas that preferentially occurs on hands and feet. It is of particular interest to understand melanoma pathogenesis, because it has different genetic factors from other melanoma subtypes and treatment. Therefore a thorough study about genomic characteristics of AM is needed to develop new treatment options. We preliminarily investigated the gene expression profiles of melanomas. Objectives: In this study, we tried to compare genomic patterns of melanomas with normal tissues and also compare gene expressions of AM with those of superficial spreading melanomas (SSM). Methods: We obtained fresh frozen tissue samples from AM and SSM, as well as normal skin and carried out cDNA microarray analysis. We also compared the gene expressions of AM, SSM, and normal tissues by RT-PCR. Results: We identified 742 up-regulated and 1518 down-regulated probe sets in melanoma compared to normal skin. Top 20 up-regulated genes in melanoma compared to normal skin include MLANA, PMEL, TYR, C6orf218, TRPM1, PRAME, RGS1. Conclusion: We collected data about differences in gene expression between melanomas and normal tissues, and also between AM and SSM. With this information we look forward to finding out specific genomic traits of AM and developing new biologic targets treating AM.
Kim, Jaehwan,Oh, Chil-Hwan,Jeon, Jiehyun,Baek, Yoosang,Ahn, Jaewoo,Kim, Dong Joo,Lee, Hyun-Soo,da Rosa, Joel Correa,Suá,rez-Fariñ,as, Mayte,Lowes, Michelle A.,Krueger, James G. Nature Publishing Group 2016 The Journal of investigative dermatology Vol.136 No.1
<P>Psoriasis is present in all racial groups, but in varying frequencies and severity. Considering that small plaque psoriasis is specific to the Asian population and severe psoriasis is more predominant in the Western population, we defined Asian <I>small</I> and <I>intermediate</I> plaque psoriasis as psoriasis subtypes, and compared their molecular signatures with classic subtype of Western <I>large</I> plaque psoriasis. Two different characteristics of psoriatic spreading—vertical growth and radial expansion—were contrasted between subtypes, and genomic data were correlated to histologic and clinical measurements. Compared to Western <I>large</I> plaque psoriasis, Asian <I>small</I> plaque psoriasis revealed limited psoriasis spreading, but IL-17A and IL-17-regulated pro-inflammatory cytokines were highly expressed. Paradoxically, IL-17A and IL-17-regulated pro-inflammatory cytokines were lower in Western <I>large</I> plaque psoriasis, while T cells and dendritic cells in total psoriatic skin area were exponentially increased. Negative immune regulators, such as CD69 and FAS, were decreased in both Western <I>large</I> plaque psoriasis and psoriasis with accompanying arthritis or obesity, and their expression was correlated with psoriasis severity index. Based on the disease subtype comparisons, we propose that dysregulation of T cell expansion enabled by downregulation of immune negative regulators is the main mechanism for development of large plaque psoriasis subtypes.</P>