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Simultaneous HPLC determination of multiple compounds in a cosmetic lotion
( Baeksun Abn ),( Cbulhee Jung ),( Hosoon Lim ),( Hoosub Lee ),( Sanghoon Lee ) 대한화장품학회 2003 대한화장품학회지 Vol.29 No.1
고속액체크로마토크래피 방법을 사용하여 동시에 arbutin, 메탄올에 녹인 methyl, ethyl, propyl, butyl parben과 glablidine(유용성 감초추출물)을 파장 254와 276 nm 에서 Gradient methanol로 octadecyl culumn 을 사용하여 측정하였다. arbutin와 glablidine 농도 0.5-10 μg/ml, 파라벤류는 0.1-20μg/ml 에서 검량선이 직선으로 작성되었다. 검량이 직선으로 나타나 정량분석을 할 수 있다는 것을 알 수 있었다. 샘플 전처리가 크로마토그래피로 측정하기에 좋은 방법이란 것을 판정하기 위하여 일반로션을 사용하여 판정하였다. 이 방법의 정확도는 모든 즉정물질(arbutin, methylparaben, ethylparaben, propylparaben, butylparaben, glablidine)의 회수율 상대표준편차(RSD)가(0.28-2.55%) 나타나 신뢰성 있는 결과를 보였다. A high-performance liquid chromatographic method for the simultaneous determination of arbutine, a mixture of methyl, ethyl, propyl, butyl parabens dissolved in methanol and Glrablidine(Oil Soluble Licorice), was studied by usmg a ODS C18 column and a methanol gradient at 254 and 276 nm. Calibration curves were found to be linear in the 0.5-10 μg/ml range(compounds arbutine, glrablidin) and 0.1-20 μg/ml(compounds methylparaben, ethylparaben, propylparaben, butylparaben). Linear regression analysis of the data demonstrates the efficacy of the method in terms of precision and accuracy. An extraction method is developed and validated in order to apply this chromatographic method to a cosmetic lotion. The precision of this method, calculated as the relative standard deviation(RSD) of the recoveries(0.28-2.55%) was excellent for all compounds.
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Ji, Hye-Young,Lee, Seung-Seok,Yoo, Sung-Eun,Kim, Hosoon,Lee, Dong-Ha,Lim, Hong,Lee, Hye-Suk The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.2
KR-31543, (2S,3R,4S)-6-amino-4-[N-(4-chlorophenyl)-N-(2 -methyl-2H-tetrazol-5-ylmethyl) amino]-3,4-dihydro-2-dimethoxymethyl-3-hydroxy-2-methyl-2H-1-benzopyran, is a new neuroprotective agent for preventing ischemia-reperfusion damage. This study was performed to identify the metabolic pathway of KR-31543 in human liver microsomes and to characterize cytochrome P450 (CYP) enzymes that are involved in the metabolism of KR-31543. Human liver microsomal incubation of KR-31543 in the presence of NADPH resulted in the formation of two metabolites, M1 and M2. M1 was identified as N-(4-chlorophenyl)-N-(2-methyl-2H-tetrazol-5-ylmethyl)amine on the basis of LC/MS/MS analysis with a synthesized authentic standard, and M2 was suggested to be hydroxy-KR-31543. Correlation analysis between the known CYP enzyme activities and the rates of the formation of M 1 and M2 in the 12 human liver microsomes have showed significant correlations with testosterone 6$\beta$-hydroxylase activity (a marker of CYP3A4). Ketoconazole, a selective inhibitor of CYP3A4, and anti-CYP3A4 monoclonal antibodies potently inhibited both N-hydrolysis and hydroxylation of KR-31543 in human liver microsomes. These results provide evidence that CYP3A4 is the major isozyme responsible for the metabolism of KR-31543 to M1 and M2.
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APPLICATION OF RERFLUOROPOLYMETHYLISOPROPYLETHER TO HAND CARE CREAM USING ADSORPTION AND DISPERSION
( Baeksun Ahn ),( Dongug-sliin ),( Pangu-jo ),( Sangie-kim ),( Hosoon-lim ) 대한화장품학회 1997 대한화장품학회지 Vol.23 No.3
It has been used that fluorinated compounds could be applied to cosmetic products. It is that fluori- nated compounds are hydrophobicity and lipophobicity. These fluorinated compounds are reported to form a highly protective and effective film against most aggressive chemical and physical agents. FerfluoropolymethylisopropylEther(PFPE) has homophobicity and are colorless, odorless, tasteless and non-greasy. In this we made a success to formulate the new type of hand care cream using PFPE. PFPE are suitable thickness and chemical inertness to skin. The reason that we select PFPE for this investigation. We developed the new type hand care cream by adsorption and dispersion of PFPE. There are very stable dispersion and highly moisture diffusion control. And these characteristics were verified by actual consumer test.
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