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Yang, Kun,Park, Chae G,Cheong, Cheolho,Bulgheresi, Silvia,Zhang, Shusheng,Zhang, Pei,He, Yingxia,Jiang, Lingyu,Huang, Hongping,Ding, Honghui,Wu, Yiping,Wang, Shaogang,Zhang, Lin,Li, Anyi,Xia, Lianxu,B Nature Publishing Group 2015 Immunology and Cell Biology Vol. No.
<P><I>Yersinia pestis</I> is a Gram‐negative bacterium that causes plague. After <I>Y. pestis</I> overcomes the skin barrier, it encounters antigen‐presenting cells (APCs), such as Langerhans and dendritic cells. They transport the bacteria from the skin to the lymph nodes. However, the molecular mechanisms involved in bacterial transmission are unclear. Langerhans cells (LCs) express Langerin (CD207), a calcium‐dependent (C‐type) lectin. Furthermore, <I>Y. pestis</I> possesses exposed core oligosaccharides. In this study, we show that <I>Y. pestis</I> invades LCs and Langerin‐expressing transfectants. However, when the bacterial core oligosaccharides are shielded or truncated, <I>Y. pestis</I> propensity to invade Langerhans and Langerin‐expressing cells decreases. Moreover, the interaction of <I>Y. pestis</I> with Langerin‐expressing transfectants is inhibited by purified Langerin, a DC‐SIGN (DC‐specific intercellular adhesion molecule 3 grabbing nonintegrin)‐like molecule, an anti‐CD207 antibody, purified core oligosaccharides and several oligosaccharides. Furthermore, covering core oligosaccharides reduces the mortality associated with murine infection by adversely affecting the transmission of <I>Y. pestis</I> to lymph nodes. These results demonstrate that direct interaction of core oligosaccharides with Langerin facilitates the invasion of LCs by <I>Y. pestis</I>. Therefore, Langerin‐mediated binding of <I>Y. pestis</I> to APCs may promote its dissemination and infection.</P>
Zhang, Qianrui,Chen, Kang,Wu, Tao,Song, Hongping The Korean Society of Pharmacology 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.1
Swertiamarin (STM) is an iridoid compound that is present in the Gentianaceae swertia genus. Here we investigated antiapoptotic effects of STM on carbon tetrachloride ($CCl_4$)-induced liver injury and its possible mechanisms. Adult male Sprague Dawley rats were randomly divided into a control group, an STM 200 mg/kg group, a $CCl_4$ group, a $CCl_4+STM$ 100 mg/kg group, and a $CCl_4+STM$ 200 mg/kg group. Rats in experimental groups were subcutaneously injected with 40% $CCl_4$ twice weekly for 8 weeks. STM (100 and 200 mg/kg per day) was orally given to experimental rats by gavage for 8 consecutive weeks. Hepatocyte apoptosis was determined by TUNEL assay and the expression levels of Bcl-2, Bax, and cleaved caspase-3 proteins were evaluated by western blot analysis. The expression of $TGF-{\beta}1$, collagen I, collagen III, CTGF and fibronectin mRNA were estimated by qRT-PCR. The results showed that STM significantly reduced the number of TUNEL-positive cells compared with the $CCl_4$ group. The levels of Bax and cleaved caspase-3 proteins, and $TGF-{\beta}1$, collagen I, collagen III, CTGF, and fibronectin mRNA were significantly reduced by STM compared with the $CCl_4$ group. In addition, STM markedly abrogated the repression of Bcl-2 by $CCl_4$. STM also attenuated the activation of the PI3K/Akt pathway in the liver. These results suggested that STM ameliorated $CCl_4$-induced hepatocyte apoptosis in rats.
One-step synthesis of mesoporous sulfated zirconia nanoparticles with anionic template
Hongping Pu,Yongming Luo,Liuyi Zhang,Dongquan Du,Caiyun Han,Hongyin Li,Jiangyan Li 한국화학공학회 2012 Korean Journal of Chemical Engineering Vol.29 No.10
Mesoporous sulfated zirconia nanoparticles (MSZNP) with high surface area have been synthesized by using sodium dodecyl sulfate (C12H25OSO3Na, SDS), both as a template and a sulfating agent via one-step route. On the basis of FT-IR, EDS together with NH3-TPD analyses, the SO42− anion, originated from the hydrophilic head of SDS, can be incorporated into ZrO2 to form MSZNP with super-acidity. The phase transition of ZrO2 from tetragonal to monoclinic phase was effectively inhibited by the presence of SO42−, and the formation mechanism was illustrated in detail. MSZNP(550) achieved far higher activity than CSZ(550) in transesterification of soybean oil with methanol due to the synergistic effect of strong acidity, high BET surface area and the formation of mesostructure.
Sun, Hongping,Zhang, Yapei,Tian, Wenxi,Qiu, Suizheng,Su, Guanghui Korean Nuclear Society 2020 Nuclear Engineering and Technology Vol.52 No.5
The aim in the present work is to simulate accident scenarios of AP1000 during the small-break loss-of-coolant accident (SBLOCA) and investigate the performance and behavior of automatic depressurization system (ADS) during accidents by using MIDAC (The Module In-vessel Degradation severe accident Analysis Code). Four types of accidents with different hypothetical conditions were analyzed in this study. The impact on the thermal-hydraulic of the reactor coolant system (RCS), the passive core cooling system and core degradation was researched by comparing these types. The results show that the RCS depressurization becomes faster, the core makeup tanks (CMT) and accumulators (ACC) are activated earlier and the effect of gravity water injection is more obvious along with more ADS valves open. The open of the only ADS1-3 can't stop the core degradation on the basis of the first type of the accident. The open of ADS1-3 has a great impact on the injection time of ACC and CMT. The core can remain intact for a long time and the core degradation can be prevent by the open of ADS-4. The all results are significant and meaningful to understand the performance and behavior of the ADS during the typical SBLOCA.
Human capital, financial constraints, and innovation investment persistence
Peng Hongxing,Tan Hongping,Zhang Yin 기술경영경제학회 2020 ASIAN JOURNAL OF TECHNOLOGY INNOVATION Vol.28 No.3
We examine the impact of human capital on innovation investment persistence using a sample of high-tech companies listed in the Chinese A-share market for the period 2009–2017. We find that human capital mitigates the negative effect of financial constraints on innovation investment persistence. We further explore the mechanism through which human capital at the management and employee levels affects innovation investment persistence. We find that management human capital affects innovation investment persistence through the expectation of authorised patents, while employee human capital affects the persistence through salary stickiness. Furthermore, we find that management human capital contributes to an increase in future granted patents through persistent innovation investment.
Assessment of Neoadjuvant Treatment Response Using Automated Breast Ultrasound in Breast Cancer
Xiaozhi Dang,Xin Zhang,Yi Gao,Hongping Song 한국유방암학회 2022 Journal of breast cancer Vol.25 No.4
Breast imaging techniques are used to assess the tumor response to neoadjuvant treatment (NAT), which is increasingly one of the preferred therapeutic options and increases the rate of breast conservation for breast cancer. Herein, we report a case in which a woman was diagnosed with invasive ductal carcinoma in the left breast and received NAT before surgery. Automated breast ultrasound (AB US) was regularly performed before and during the NAT to evaluate the tumor response to NAT by measuring diameter changes and volume reductions of the tumor. Images showed that the tumor size was significantly reduced and disappeared after 7 cycles of NAT, except for macrocalcification. Postoperative histopathological examination confirmed that there were no residual tumor cells. We found that AB US overcame the limitations of handheld US, such as operator dependence, poor reproducibility and limited field of view, and can be an alternative modality to assess the tumor response of NAT in the absence of magnetic resonance imaging (MRI) instruments.
Identification of Glycine Max MicroRNAs in Response to Phosphorus Deficiency
Aihua Sha,Yinhua Chen,Hongping Ba,Zhihui Shan,Xiaojuan Zhang,Xuejun Wu,Dezheng Qiu,Shuilian Chen,Xinan Zhou 한국식물학회 2012 Journal of Plant Biology Vol.55 No.4
MicroRNAs (miRNAs) are endogenous small RNAs regulating plant development and stress responses. In addition, phosphorus (P) is an important macronutrient for plant growth and development. More than two hundred miRNAs have been identified in Glycine Max and a few of miRNAs have been shown to respond to P deficiency,however, whether there are other miRNAs involved in P deficiency response is largely unknown. In this study, we used high-throughput small RNA sequencing and wholegenome-wide mining to identify the potential miRNAs in response to P deficiency. After sequencing, we deduced 183known, 99 conserved and 126 novel miRNAs in Glycine Max. Among them, in response to P deficiency, the expressions of 27 known, 16 conserved and 12 novel miRNAs showed significant changes in roots, whereas the expressions of 34known, 14 conserved and 7 novel miRNAs were significantly different in shoots. Furthermore, we validated the predicated novel miRNAs and found that three miRNAs in roots and five miRNAs in shoots responded to P deficiency. Some miRNAs were P-induced whereas some were P-suppressed. Together these results indicated that the miRNAs identified might play important roles in regulating P signaling pathway.