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RISS 인기검색어
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- 저자 : ( Hitoshi Nukada ) (검색결과 1 건)
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Poster Session : PS 0133 ; Neurology : Hypertensive Neuropathy in Rat
( Hitoshi Nukada ),( Masayuki Baba ),( Denise Mcmorran ),( Soroku Yzgihashi ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Hypertension is identifi ed as a risk factor for the development of polyneuropathy. We examined nerve conduction and pathology in spontaneously hypertensive rats (SHR). Methods: Motor nerve conduction velocity (MNCV) in sciatic-tibial nerve and sensory nerve conduction velocity (SNCV) in sural nerve were measured. Pathological investigations include spinal cord, dorsal root ganglion, and hindlimb nerves in SHR and Wistar-Kyoto rats (WKY) aged from 4 to 64 weeks. Results: Blood pressure was signifi cantly higher in SHR than WKY at 4 weeks and elevated further with aging. MNCV and SNCV were signifi cantly slowed in SHR when compared with WKY after 24 weeks old. Prominent nerve pathology in SHR included axonal atrophy and myelin splitting. SHR nerves revealed microangiopathy with reduplication of basement membrane. Conclusions: Sustained severe hypertension results in neuropathic processes with endoneurial microangiopathy. Hypertensive target organ damage includes the peripheral nervous system, and subjects with uncontrolled hypertension could develop neuropathy.
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