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( Tsuyoshi Hamada ),( Hideo Yasunaga ),( Yousuke Nakai ),( Hiroyuki Isayama ),( Hiromasa Horiguchi ),( Shinya Matsuda ),( Kiyohide Fushimi ),( Kazuhiko Koike ) The Editorial Office of Gut and Liver 2014 Gut and Liver Vol.8 No.2
Background/Aims: Endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) is useful for the pathological diagnosis of pancreatic masses, but patients are susceptible to severe bleeding and perforation. Because the incidence and severity of these complications have not been fully evaluated. Methods: We aimed to evaluate severe bleeding and perforation after EUS-FNA for pancreatic masses using large-scale data derived from a Japanese nationwide admin-istrative database. Results: In total, 3,090 consecutive pa-tients from 212 low- to high-volume hospitals were analyzed. Severe bleeding requiring transfusion or endoscopic treat-ment occurred in seven patients (0.23%), and no perforation was observed. No patient mortality was recorded within 30 days of EUS-FNA. The rate of severe bleeding in low-volume hospitals was significantly higher than that in medium- and high-volume hospitals (0.48% vs 0.10%, p=0.045). Conclu-sions: Severe bleeding and perforation following EUS-FNA for pancreatic masses are rare, and the procedure is safe. (Gut Liver 2014;8:215-218)