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- 저자 : ( Hidemoto Saiki ) (검색결과 1 건)
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( Mayumi Toyama ),( Yasuyuki Okuma ),( Mitsutoshi Yamamoto ),( Kenichi Kashihara ),( Kazuto Yoshda ),( Hidemoto Saiki ),( Tetsuya Maeda ),( Yoshio Tsuboi ),( Takeo Nakayama ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Parkinson`s disease (PD) is increasingly recognized as multidimensional disorder. In addition to classic motor symptoms, patients have a variety of non-motor symptoms (NMS) that substantially affect quality of life (QoL). However, the prevalence of NMS and the relative impact of non-motor symptoms on QoL in PD have not been well documented in Japanese PD patients. In this study, we have the following objectives: 1) To determine the prevalence of NMS in Japanese PD patients. 2) To study the impact of NMS on the QoL in Japanese PD patients. Methods: This was a multi-center cross-sectional epidemiologic study. We recruited outpatients from seven Neurology departments at general hospitals across Japan between October 2010 and September 2011. A total of 824 Japanese PD patients was included in this study. NMS of patients was evaluated by Non-Motor Symptoms Scale (NMSS). Parkinson`s Disease Questionnaire-39 (PDQ-39) was used to evaluate the QoL of PD patients. Multivariate analyses were used to evaluate the direct impact of NMSs on QoL using PDQ-39, after adjusting for age, sex, disease duration, and the Unifi ed Parkinson`s Disease Rating Scale (UPDRS) Part I, Part II, Part III and Part IV. Results: The mean of total NMSS score was 37.4±35.4. The highly prevalent NMSS domains were sleep/fatigue (87.6%) and urinary (86.1%). The highly prevalent NMSS items were nocturia (72.0%) and constipation (71.6%). In multivariate analyses after adjustment for age, sex, disease duration, UPDRS Part I, Part II, Part III, and Part IV, total score of NMSS has statistical signifi cance with PDQ-39 (p=0.00, ß=0.16, Adj-R squared=0.65). Conclusions: NMS were highly prevalent in Japanese PD patients. NMS have a direct negative impact on QoL in Japanese PD patients.
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