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RISS 인기검색어
- 검색키워드
- 저자 : ( Henrik H. Hansen ) (검색결과 3 건)
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Disulfide polymer grafted porous carbon composites for heavy metal removal from stormwater runoff
Ko, Dongah,Mines, Paul D.,Jakobsen, Mogens H.,Yavuz, Cafer T.,Hansen, Hans Chr. B.,Andersen, Henrik R. Elsevier 2018 Chemical engineering journal Vol.348 No.-
<P><B>Abstract</B></P> <P>The emerging concern of heavy metal pollution derived from stormwater runoff has triggered a demand for effective heavy metal sorbents. To be an effective sorbent, high affinity along with rapid sorption kinetics for environmental relevant concentrations of heavy metals is important. Herein, we have introduced a new composite suitable for trace metal concentration removal, which consists of cheap and common granular activated carbon covered with polymers containing soft bases, thiols, through acyl chlorination (DiS-AC). Material characterization demonstrated that the polymer was successfully grafted and grown onto the surface of the carbon substrate. The distribution coefficient for Cd<SUP>2+</SUP> bonding was 89·10<SUP>3</SUP> L/kg at a solution concentration of 0.35 mg/L, which is notably higher than sorption affinities for Cd<SUP>2+</SUP> seen in conventional sorbents. The sorption isotherm is well described by the Freundlich isotherm and within an hour, half of the initial trace (0.2 mg/L) concentration of Cd<SUP>2+</SUP> was removed by the DiS-AC at a sorbent loading of 2 g/L. Therefore, the novel material DiS-AC promises to be an ideal candidate for filters treating stormwater runoff.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The novel disulfide polymer grafted activated carbon composites were devised. </LI> <LI> Covalent bonds between disulfide polymer and carbon substrate have been proven. </LI> <LI> DiS-AC showed rapid kinetics on removing heavy metal in overall range of pH 6–8. </LI> <LI> DiS-AC showed high affinity towards even for trace amount of heavy metal in water. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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Selective removal of heavy metal ions by disulfide linked polymer networks
Ko, Dongah,Lee, Joo Sung,Patel, Hasmukh A.,Jakobsen, Mogens H.,Hwang, Yuhoon,Yavuz, Cafer T.,Hansen, Hans Chr. Bruun,Andersen, Henrik R. Elsevier 2017 Journal of hazardous materials Vol.332 No.-
<P><B>Abstract</B></P> <P>Heavy metal contaminated surface water is one of the oldest pollution problems, which is critical to ecosystems and human health. We devised disulfide linked polymer networks and employed as a sorbent for removing heavy metal ions from contaminated water. Although the polymer network material has a moderate surface area, it demonstrated cadmium removal efficiency equivalent to highly porous activated carbon while it showed 16 times faster sorption kinetics compared to activated carbon, owing to the high affinity of cadmium towards disulfide and thiol functionality in the polymer network. The metal sorption mechanism on polymer network was studied by sorption kinetics, effect of pH, and metal complexation. We observed that the metal ions–copper, cadmium, and zinc showed high binding affinity in polymer network, even in the presence of competing cations like calcium in water.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Disulfide/thiol polymer networks are promising as sorbent for heavy metals. </LI> <LI> Rapid sorption and high Langmuir affinity constant (a<SUB>L</SUB>) for stormwater treatment. </LI> <LI> Selective sorption for copper, cadmium, and zinc in the presence of calcium. </LI> <LI> Reusability likely due to structure stability of disulfide linked polymer networks. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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( Kyungil Kim ),( Ida Rune ),( Sanne S. Veidal ),( Keun-wan Lim ),( Yunsun Park ),( Youngah Kim ),( Leo S. Choi ),( Henrik H. Hansen ),( Michael Feigh ),( Sang-ku Yoo ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: HSG4112, a synthetic new chemical entity, is a first-inclass oral small molecule in clinical development for obesity. In preclinical studies, HSG4112 as mitochondrial function enhancer has been demonstrated to increase energy expenditure and decrease chronic low-grade inflammation, resulting in reduced adiposity and robust weight loss. As these therapeutic effects are highly relevant for the management of non-alcoholic steatohepatitis (NASH), we aimed to compare the therapeutic effects of HSG4112 and semaglutide (GLP-1 receptor agonist) in a diet-induced obese (DIO) and biopsy-confirmed mouse model of NASH. Methods: Male C57BL/6JRj mice were fed AMLN diet high in trans-fat, fructose and cholesterol for 35 weeks. Only animals with liver biopsy-confirmed steatosis (score ≥2) and fibrosis (stage ≥F1) were included and stratified into treatment groups according to baseline body weight and liver collagen-1a1 deposition. DIO-NASH mice received vehicle (PO, QD), HSG4112 (50 or 100 mg/kg, PO, QD), or semaglutide (30 nmol/kg, SC, QD) for 10 weeks. Endpoints included within-subject changes in body composition, NAFLD Activity Score (NAS) and fibrosis stage as well as terminal quantitative liver histology and transcriptome analysis. Results: HSG4112 and semaglutide induced similar reductions in body weight (20%) and whole-body fat levels (10-12%) in DIO-NASH mice. These metabolic effects were accompanied by significantly reduced plasma levels of liver injury markers (ALT, AST, ALP). Notably, in contrast to semaglutide, HSG4112 did not reduce any food intake and improved NAS by a different mode of action. Accordingly, HSG4112 specifically attenuated lobular inflammation while semaglutide reduced steatosis severity. Both compounds significantly reduced fibrogenesis activity associated with suppressed stellate cell activation and lowered collagen mRNA expression. Conclusions: HSG4112 showed robust anti-obesity and anti- NASH efficacy, especially with reduced liver inflammation and fibrogenesis, in DIO-NASH mice with biopsy-confirmed liver pathology. While its efficacy was comparable to that of semaglutide, HSG4112 did not reduce food intake, further demonstrating its energy expenditure-enhancing effect. These findings suggest HSG4112 as a potent novel drug for the treatment of NASH.
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